Abnormal expression of epidermal growth factor and sulfated glycoprotein SGP-2 messenger RNA in a rat model of autosomal dominant polycystic kidney disease.

Cowley, Benjamin D.; Rupp, J C

doi:10.1681/asn.v661679

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Cited by 21 publications

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New Markers of Kidney Injury

Beushausen

2010

Pharmaceutical Sciences Encyclopedia

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The current biomarker standards for assessing acute kidney injury (AKI) include blood urea nitrogen (BUN) and serum creatinine (SC), which lack sensitivity and specificity for kidney injury. The combined shortcomings of BUN and SC as predictors of nephrotoxicity and the propensity for many classes of medicines to cause drug‐induced nephrotoxicity underscore the urgent need for the development and qualification of more sensitive and specific biomarkers. This article focuses on the importance of new biomarkers of nephrotoxicity in predicting and monitoring early or acute kidney injury.

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New Markers of Kidney Injury

Beushausen

2010

Pharmaceutical Sciences Encyclopedia

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New Markers of Kidney Injury

Beushausen

2020

Biomarkers in Drug Discovery and Development

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Diagnosis, Pathogenesis, and Treatment Prospects in Cystic Kidney Disease

et al. 2006

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Cystic kidney diseases (CKDs) are a clinically and genetically heterogeneous group of disorders characterized by progressive fibrocystic renal and hepatobiliary changes. Recent findings have proven the cystogenic process to be compatible with cellular dedifferentiation, i. e. increased apoptosis and proliferation rates, altered protein sorting and secretory characteristics, as well as disorganization of the extracellular matrix. Compelling evidence suggests that cilia play a central pathogenic role and most cystic kidney disorders converge into a common pathogenic pathway. Recently, several promising trials have further extended our understanding of the pathophysiology of CKD and may have the potential for rational personalized therapies in future years. This review aims to summarize the current state of knowledge of the structure and function of proteins underlying polycystic kidney disease, to explore the clinical consequences of changes in respective genes, and to discuss potential therapeutic approaches.

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Abnormal expression of epidermal growth factor and sulfated glycoprotein SGP-2 messenger RNA in a rat model of autosomal dominant polycystic kidney disease.

Cited by 21 publications

References 0 publications

New Markers of Kidney Injury

New Markers of Kidney Injury

New Markers of Kidney Injury

Diagnosis, Pathogenesis, and Treatment Prospects in Cystic Kidney Disease

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