Abnormal erythrocyte morphology in drug reaction with eosinophilia and systemic symptoms

Dorrell, Deborah N; Whitaker, Litton F.; Anderson, Kristen; Strowd, Lindsay C.

doi:10.1016/j.jaad.2018.10.064

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…In fact, in DRESS, toxic eosinophilic granule proteins are released and could affect bone marrow. The most frequent AEMs found in DRESS patients are poikilocytosis (48% of patients with AEM), polychromasia (48%), burr cells (33%), ovalocytes (33%) and others [ 186 ]. Recently, a study found that levels of TNF- α in blood samples could be useful biomarkers to detect HHV-6 infection.…”

Section: Clinical Presentation and Laboratory Findings: When To Suspe...mentioning

confidence: 99%

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Focus on the Pathophysiological and Diagnostic Role of Viruses

et al. 2023

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Drug reaction with eosinophilia and systemic symptoms (DRESS) is a heterogeneous, multiorgan and potentially life-threatening drug-hypersensitivity reaction (DHR) that occurs several days or weeks after drug initiation or discontinuation. DHRs constitute an emerging issue for public health, due to population aging, growing multi-organ morbidity, and subsequent enhanced drug prescriptions. DRESS has more consistently been associated with anticonvulsants, allopurinol and antibiotics, such as sulphonamides and vancomycin, although new drugs are increasingly reported as culprit agents. Reactivation of latent infectious agents such as viruses (especially Herpesviridae) plays a key role in prompting and sustaining aberrant T-cell and eosinophil responses to drugs and pathogens, ultimately causing organ damage. However, the boundaries of the impact of viral agents in the pathophysiology of DRESS are still ill-defined. Along with growing awareness of the multifaceted aspects of immune perturbation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the ongoing SARS-CoV-2-related disease (COVID-19) pandemic, novel interest has been sparked towards DRESS and the potential interactions among antiviral and anti-drug inflammatory responses. In this review, we summarised the most recent evidence on pathophysiological mechanisms, diagnostic approaches, and clinical management of DRESS with the aim of increasing awareness on this syndrome and possibly suggesting clues for future research in this field.

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Section: Clinical Presentation and Laboratory Findings: When To Suspe...mentioning

confidence: 99%

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Focus on the Pathophysiological and Diagnostic Role of Viruses

et al. 2023

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“…To the Editor: We read with interest the article by Dorrell et al on abnormal erythrocyte morphology in drug reaction with eosinophilia and systemic symptoms (DRESS). 1 They found that patients with DRESS have a higher rate of abnormal erythrocyte morphology than patients with other drug eruptions. They also found that DRESS patients with abnormal erythrocyte morphology had a higher possibility of showing eosinophilia and hepatic involvement.…”

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confidence: 99%

“…They also found that DRESS patients with abnormal erythrocyte morphology had a higher possibility of showing eosinophilia and hepatic involvement. 1 However, the authors put all patients with a RegiSCAR (severe cutaneous adverse reaction) score $2 into their DRESS cohort, meaning that possible, probable, and definite cases of DRESS were all included. As such, this approach might have resulted in patients with diagnoses other than DRESS being taken into account.…”

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confidence: 99%

Comment on “Abnormal erythrocyte morphology in drug reaction with eosinophilia and systemic symptoms”

Cho

Chu

2019

Journal of the American Academy of Dermatology

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“…To the Editor: Drs Cho and Chu penned a comment 1 on our recently published article on the incidence of abnormal erythrocyte morphology in patients with drug reaction with eosinophilia and systemic symptoms (DRESS). 2 We are delighted this small retrospective study has generated interest in the dermatology community. The commentary authors critique the methods of our study but also support the potential validity of our findings.…”

mentioning

confidence: 99%

Abnormal erythrocyte morphology in drug reaction with eosinophilia and systemic symptoms

Cited by 4 publications

References 5 publications

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Focus on the Pathophysiological and Diagnostic Role of Viruses

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Focus on the Pathophysiological and Diagnostic Role of Viruses

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