Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Grégoire Coppens,
Ilse Vanhorebeek,
Fabian Güiza
et al.
Abstract:Background
Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus–pituitary–adrenal (HPA) axis which may impair normal brain development, cognition and behaviour. We tested the hypothesis that paediatric-intensive-care-unit (PICU) patients, sex- and age-dependently, show long-term abnormal DNA methylation within the HPA-axis layers, possibly aggravated by glucocorticoid treatment in … Show more
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