Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder

Deng, Wenhao; Zhang, Bin; Zou, Wenjin; Zhang, Xiaofei; Cheng, Xiongchao; Guan, Lijie; Lin, Yin; Lao, Guohui; Ye, Biyu; Li, Xuan; Yang, Chanjuan; Ning, Yuping; Cao, Liping

doi:10.3389/fpsyt.2019.00140

Cited by 27 publications

(18 citation statements)

References 62 publications

(62 reference statements)

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“…DC can reflect the relative importance of a node in a network (Yang et al, 2014), which has been widely used to study neurological and psychiatric disorders. Recently, one study used DC to explore cognitive dysfunction in patients with early bipolar disorder (Deng et al, 2019). Guo et al (2016) revealed DC changes in the right middle frontal, precentral, and postcentral gyri, which fits a network dysfunction model in Alzheimer's disease (AD).…”

Section: Introductionmentioning

confidence: 89%

Alterations in Degree Centrality and Functional Connectivity in Parkinson’s Disease Patients With Freezing of Gait: A Resting-State Functional Magnetic Resonance Imaging Study

Guo

Ren

et al. 2020

Front. Neurosci.

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Objective: Freezing of gait (FOG) is a common disabling motor symptom in Parkinson's disease (PD), but the potential pathogenic mechanisms are still unclear. Methods: A total of 22 patients with PD with FOG (PD-FOG), 28 patients with PD without FOG (PD-nFOG), and 33 healthy controls (HCs) were recruited in this study. Degree centrality (DC)-a graph theory-based measurement of global connectivity at the voxel level by measuring the number of instantaneous functional connections between one region and the rest of the brain-can map brain hubs with high sensitivity, specificity, and reproducibility. DC was used to explore alterations in the centrality of PD-FOG correlated with brain node levels. PD-FOG cognitive network dysfunction was further revealed via a seed-based functional connectivity (FC) analysis. In addition, correlation analyses were carried out between clinical symptoms and acquired connectivity measurement. Results: Compared to the PD-nFOG group, the PD-FOG group showed remarkably increased DC values in the right middle frontal gyrus (RMFG). There were no significant differences in other gray matter regions. Importantly, the clinical severity of FOG was related to the mean DC values in the RMFG. This brain region served as a seed in secondary seed-based FC analysis, and we further found FC changes in the right precuneus, right inferior frontal gyrus, right superior frontal gyrus (SFG), and cerebellum. Conclusion: Increased RMFG activity and FC network alterations in the middle frontal cortex with the precuneus, inferior, and SFG, and the cerebellum may have great potential in brain dysfunction in PD with FOG.

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Section: Introductionmentioning

confidence: 89%

Alterations in Degree Centrality and Functional Connectivity in Parkinson’s Disease Patients With Freezing of Gait: A Resting-State Functional Magnetic Resonance Imaging Study

Guo

Ren

et al. 2020

Front. Neurosci.

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“…Indeed, neuroimaging studies have described cerebellar alterations in patients with bipolar disorder [ 24 , 25 , 26 , 27 ] over the last twenty years and researchers have focused on this structure [ 28 , 29 , 30 , 31 , 32 ] in light of the cerebellar connections with cortical areas involved in the pathophysiology of bipolar disorder [ 13 , 28 , 31 , 33 , 34 ] and the cerebellar role in emotion [ 35 , 36 , 37 , 38 , 39 ], social cognition [ 16 , 40 , 41 ] and cognitive functions [ 42 , 43 , 44 , 45 ]. Moreover, it is worth noting that very recently the onset of mood disorders (manic and depressive symptoms) has been demonstrated in the presence of isolated cerebellar lesions and neurodegenerative cerebellar pathologies [ 46 , 47 , 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cerebellar Grey Matter Alterations in Bipolar and Cerebellar Patients: Evidence from Voxel-Based Analysis

Lupo

Olivito

Gragnani

et al. 2021

IJMS

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The aim of this study was to compare the patterns of cerebellar alterations associated with bipolar disease with those induced by the presence of cerebellar neurodegenerative pathologies to clarify the potential cerebellar contribution to bipolar affective disturbance. Twenty-nine patients affected by bipolar disorder, 32 subjects affected by cerebellar neurodegenerative pathologies, and 37 age-matched healthy subjects underwent a 3T MRI protocol. A voxel-based morphometry analysis was used to show similarities and differences in cerebellar grey matter (GM) loss between the groups. We found a pattern of GM cerebellar alterations in both bipolar and cerebellar groups that involved the anterior and posterior cerebellar regions (p = 0.05). The direct comparison between bipolar and cerebellar patients demonstrated a significant difference in GM loss in cerebellar neurodegenerative patients in the bilateral anterior and posterior motor cerebellar regions, such as lobules I−IV, V, VI, VIIIa, VIIIb, IX, VIIb and vermis VI, while a pattern of overlapping GM loss was evident in right lobule V, right crus I and bilateral crus II. Our findings showed, for the first time, common and different alteration patterns of specific cerebellar lobules in bipolar and neurodegenerative cerebellar patients, which allowed us to hypothesize a cerebellar role in the cognitive and mood dysregulation symptoms that characterize bipolar disorder.

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“…However, better psychomotor speed was generally considered related to larger gray matter volumes in the bilateral prefrontal lobe, bilaterally hippocampus, and left superior temporal gyrus in normal controls (26). Psychomotor speed was associated with degree centrality abnormalities of the temporal lobe in early BD patients (27). Furthermore, a positive relationship between the inferior temporal surface area and psychomotor speed was reported in BD (28).…”

Section: Discussionmentioning

confidence: 99%

The characteristic of cognitive impairments in patients with bipolar II depression and its association with N-acetyl aspartate of the prefrontal white matter

Zhong¹,

Lai²,

Yue³

et al. 2020

Ann Transl Med

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Background: Cognitive deficit is acknowledged as a core feature of clinical manifestations of bipolar disorder (BD). However, the underlying mechanism of cognitive impairment in bipolar II depression has remained uncertain. We aim to determine the association of cognitive impairments with biochemical metabolism using proton magnetic resonance spectroscopy ( 1 H-MRS) and a battery of neuropsychological testing. Methods: The current study was designed to assess four cognitive domains in a sample of 110 patients with bipolar II depression and 110 healthy controls, using a battery of 6 cognitive tests, including the Digit Symbol Substitution Test (DSST), Wisconsin Cart Sorting Test (WCST), Trail Making Test Part B (TMT-B), Digit Span Test (DST), TMT-part A (TMT-A) and Verbal Fluency Test (VFT). Metabolite levels were obtained in the following brain regions of interest: bilateral prefrontal white matter (PWM), bilateral anterior cingulate cortex (ACC), bilateral lenticular nucleus (LN), and bilateral thalamus. N-acetyl aspartate (NAA)/creatine (Cr) and choline-containing compounds (Cho)/Cr ratios are analyzed. Results: Patients with bipolar II depression performed significantly worse on DSST (score), TMT (completion time), DSB (score), and VFT (valid word number) when compared with healthy controls. In the bilateral PWM, NAA/Cr ratios in the PWM were significantly reduced (bilaterally) than those in healthy controls. Correlation analysis was conducted with data from patients with bipolar II depression, we found that the NAA/Cr ratio of the left PWM was positively correlated with the score of DS and DSB, and the NAA/Cr ratio of the right PWM was negatively correlated with the completion time of TMT-B. Conclusions: Our findings suggested that psychomotor speed, executive function, working memory, and verbal fluency are impaired in patients with BD II depression. Hypoactivity NAA/Cr in bilateral PWM may be associated with BD II depression's pathophysiology and results in cognitive dysfunction.

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Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder

Cited by 27 publications

References 62 publications

Alterations in Degree Centrality and Functional Connectivity in Parkinson’s Disease Patients With Freezing of Gait: A Resting-State Functional Magnetic Resonance Imaging Study

Alterations in Degree Centrality and Functional Connectivity in Parkinson’s Disease Patients With Freezing of Gait: A Resting-State Functional Magnetic Resonance Imaging Study

Comparison of Cerebellar Grey Matter Alterations in Bipolar and Cerebellar Patients: Evidence from Voxel-Based Analysis

The characteristic of cognitive impairments in patients with bipolar II depression and its association with N-acetyl aspartate of the prefrontal white matter

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