Abnormal default-mode network activation in cirrhotic patients: a functional magnetic resonance imaging study

Zhang, Long Jiang; Yang, Gui Fen; Yin, Jianzhong; Liu, Yawu; Qi, Ji

doi:10.1080/02841850701422161

Cited by 28 publications

(17 citation statements)

References 22 publications

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“…For example, a recent study combining positron emission tomography (PET) and fMRI showed that striatal dopamine transporter (DAT) availability can modulate task-related DMN deactivation (46). Also, similar to a recent fMRI study in cirrhotic patients (47), absence of PCC deactivation during a Stroop task may predict or be a marker of a greater need in alcoholics to use reserve network resources to achieve comparable performance levels to that of controls.…”

Section: Discussionsupporting

confidence: 65%

Synchrony of Corticostriatal-Midbrain Activation Enables Normal Inhibitory Control and Conflict Processing in Recovering Alcoholic Men

Schulte

Müller‐Oehring

Sullivan

et al. 2012

Biological Psychiatry

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Background Alcohol dependence is associated with inhibitory control deficits, possibly related to abnormalities in frontoparietal cortical and midbrain function and connectivity. Methods We examined functional connectivity and microstructural fiber integrity between frontoparietal and midbrain structures using a Stroop Match-to-Sample task with functional MRI and diffusion tensor imaging in 18 alcoholics and 17 controls. Manipulation of color cues and response repetition sequences modulated cognitive demands during Stroop conflict. Results Despite similar lateral frontoparietal activity and functional connectivity in alcoholics and controls when processing conflict, controls deactivated the posterior cingulate cortex (PCC), whereas alcoholics did not. Posterior cingulum fiber integrity predicted the degree of PCC deactivation in controls but not alcoholics. Also, PCC activity was modulated by executive control demands: activated during response switching and deactivated during response repetition. Alcoholics showed the opposite pattern: activation during repetition and deactivation during switching. Here, in alcoholics, greater deviations from the normal PCC activity correlated with higher amounts of lifetime alcohol consumption. A functional dissociation of brain network connectivity between the groups further showed that controls exhibited greater corticocortical connectivity between middle cingulate, posterior cingulate, and medial prefrontal cortices than alcoholics. By contrast, alcoholics exhibited greater midbrain-orbitofrontal cortical network connectivity than controls. Degree of microstructural fiber integrity predicted robustness of functional connectivity. Conclusion Thus, even subtle compromise of microstructural connectivity in alcoholism can influence modulation of functional connectivity and underlie alcohol-related cognitive impairment.

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Section: Discussionsupporting

confidence: 65%

Synchrony of Corticostriatal-Midbrain Activation Enables Normal Inhibitory Control and Conflict Processing in Recovering Alcoholic Men

Schulte

Müller‐Oehring

Sullivan

et al. 2012

Biological Psychiatry

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“…Note, however, that this does not implicate that there exists a simple one-to-one relationship between functional and structural connectivity. Finally, recent investigations corroborated findings that functional and structural measures of DMN connectivity have potential utility in distinguishing between mental pathologies, especially Alzheimer's dementia, and healthy controls [26, 27]. Such investigations lead to the suggestion that distorted functioning of the DMN might form the basis for many brain diseases like Autism, depressions, Parkinson's disease, Alzheimer, and related dementias.…”

Section: Experimental Studies On Functional Connectivitymentioning

confidence: 59%

Brain Connectivity Analysis: A Short Survey

Lang

Tomé

Keck

et al. 2012

Computational Intelligence and Neuroscience

126

105

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This short survey the reviews recent literature on brain connectivity studies. It encompasses all forms of static and dynamic connectivity whether anatomical, functional, or effective. The last decade has seen an ever increasing number of studies devoted to deduce functional or effective connectivity, mostly from functional neuroimaging experiments. Resting state conditions have become a dominant experimental paradigm, and a number of resting state networks, among them the prominent default mode network, have been identified. Graphical models represent a convenient vehicle to formalize experimental findings and to closely and quantitatively characterize the various networks identified. Underlying these abstract concepts are anatomical networks, the so-called connectome, which can be investigated by functional imaging techniques as well. Future studies have to bridge the gap between anatomical neuronal connections and related functional or effective connectivities.

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“…Several task-related [8], [9], [10] and resting-state fMRI (rs-fMRI) [11], [12] studies have demonstrated functional impairments in MHE or OHE patients and negative correlations of these brain abnormalities with clinical marks of HE, such as venous blood ammonia levels. Of fMRI analysis methods, regional homogeneity (ReHo) developed by Zang et al [13], has been widely used to investigate the functional modulations in many brain diseases such as major depression [14], Parkinson’s Disease [15], and Alzheimer’s disease [16].…”

Section: Introductionmentioning

confidence: 99%

Altered Regional Homogeneity in the Development of Minimal Hepatic Encephalopathy: A Resting-State Functional MRI Study

Zhang

et al. 2012

PLoS ONE

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BackgroundLittle is known about how spontaneous brain activity progresses from non-hepatic encephalopathy (non-HE) to minimal HE (MHE). The purpose of this study was to evaluate the evolution pattern of spontaneous brain activities in cirrhotic patients using resting-state fMRI with a regional homogeneity (ReHo) method.Methodology/Principal FindingsResting-state fMRI data were acquired in 47 cirrhotic patients (minimal HE [MHE], n = 20, and non-HE, n = 27) and 25 age-and sex-matched healthy controls. The Kendall’s coefficient of concordance (KCC) was used to measure the regional homogeneity. The regional homogeneity maps were compared with ANOVA tests among MHE, non-HE, and healthy control groups and t-tests between each pair in a voxel-wise way. Correlation analyses were performed to explore the relationships between regional ReHo values and Child-Pugh scores, number connection test type A (NCT-A), digit symbol test (DST) scores, venous blood ammonia levels. Compared with healthy controls, both MHE and non-HE patients showed decreased ReHo in the bilateral frontal, parietal and temporal lobes and increased ReHo in the bilateral caudate. Compared with the non-HE, MHE patients showed decreased ReHo in the bilateral precuneus, cuneus and supplementary motor area (SMA). The NCT-A of cirrhotic patients negatively correlated with ReHo values in the precuneus, cuneus and lingual gyrus. DST scores positively correlated with ReHo values in the cuneus, precuneus and lingual gyrus, and negatively correlated with ReHo values in the bilateral caudate (P<0.05, AlphaSim corrected).Conclusions/SignificanceDiffused abnormal homogeneity of baseline brain activity was nonspecific for MHE, and only the progressively decreased ReHo in the SMA and the cuneus, especially for the latter, might be associated with the development of MHE. The ReHo analysis may be potentially valuable for detecting the development from non-HE to MHE.

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Abnormal default-mode network activation in cirrhotic patients: a functional magnetic resonance imaging study

Abstract: The functional as well as behavioral data suggest that cirrhotic patients may have an abnormal deactivation mode. The absence of deactivation in the PCC and precuneus may be a sensitive rather than specific marker in patients with hepatic cirrhosis.

Cited by 28 publications

References 22 publications

Synchrony of Corticostriatal-Midbrain Activation Enables Normal Inhibitory Control and Conflict Processing in Recovering Alcoholic Men

Synchrony of Corticostriatal-Midbrain Activation Enables Normal Inhibitory Control and Conflict Processing in Recovering Alcoholic Men

Brain Connectivity Analysis: A Short Survey

Altered Regional Homogeneity in the Development of Minimal Hepatic Encephalopathy: A Resting-State Functional MRI Study

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