“…Although protein misfolding or altered trafficking is considered to be the major biochemical features of many RP mutations in Rh (16 -19), some mutations do not induce major structural defects (20,21) but cause changes in G-protein binding and activation (22,23) or the formation of altered photointermediates (24,25), among other phenotypes (17,(25)(26)(27)(28). Sector RP is an atypical form of RP, ranging from stationary to slowly progressive evolution of the retinal degenerative pattern, characterized by regional areas of bone spicule pigmentation, subnormal electroretinogram, and visual-field defects, usually in the inferior quadrant of the retina (29,30).…”