Abnormal Cytokine Profiles in Patients with Idiopathic Dilated Cardiomyopathy and Their Asymptomatic Relatives

Jb, Marriott; Goldman, JH; Keeling, PJ; Baig, MK; Ag, Dalgleish; Kenna, Wjmc

doi:10.1042/cs090008pa

Cited by 18 publications

(19 citation statements)

References 5 publications

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“…40 Serum levels of IL-10 were elevated in some patients with DCM, but not in patients with ICM. 40 However, in the present, the background diseases of CHF did not affect the serum levels of IL-10.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Cytokine Profile in Human Heart Failure

et al. 1999

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Cytokine Profile in Human Heart Failure

et al. 1999

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“…Recent studies have demonstrated that the development of DCM is accompanied by increased circulating levels of these specific cytokines. 37,38 Thus increased levels of specific cytokines with the development of DCM may modulate MMP species abundance. The MMPs are a family of metalloproteinases in which catalytic activity is influenced by substrate product stoichiometry.…”

Section: Discussionmentioning

confidence: 99%

Increased Matrix Metalloproteinase Activity and Selective Upregulation in LV Myocardium From Patients With End-Stage Dilated Cardiomyopathy

et al. 1998

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Background-One of the hallmarks of dilated cardiomyopathy (DCM) is left ventricular (LV) remodeling. The matrix metalloproteinases (MMPs) are a family of enzymes that contribute to extracellular remodeling in several disease states. Additionally, a family of inhibitors called tissue inhibitors of MMPs (TIMPs) has been shown to exist and to tightly regulate MMP activity. However, the types of MMPs and TIMPs expressed within the normal and DCM LV myocardium and the relation to MMP activity remain unexplored. Methods and Results-Relative LV myocardial MMP activity was determined in the normal (nϭ8) and idiopathic DCM (nϭ7) human LV myocardium by substrate zymography. Relative LV myocardial abundance of interstitial collagenase (MMP-1), stromelysin (MMP-3), 72 kD gelatinase (MMP-2), 92 kD gelatinase (MMP-9), TIMP-1, and TIMP-2 were measured with quantitative immunoblotting. LV myocardial MMP zymographic activity increased with DCM compared with normal (984Ϯ149 versus 413Ϯ64 pixels, PϽ.05). With DCM, LV myocardial abundance of MMP-1 decreased to 16Ϯ6% (PϽ.05), MMP-3 increased to 563Ϯ212% (PϽ.05), MMP-9 increased to 422Ϯ64% (PϽ.05), and MMP-2 was unchanged when compared with normal. LV myocardial abundance of TIMP-1 and TIMP-2 increased by Ͼ500% with DCM. A high-molecular-weight immunoreactive band for both TIMP-1 and TIMP-2, suggesting a TIMP/MMP complex, was increased Ͼ600% with DCM. Conclusions-This study demonstrated increased LV myocardial MMP activity and evidence for independent regulatory mechanisms of MMP and TIMP expression with DCM. These findings suggest that selective inhibition of MMP species within the LV myocardium may provide a novel therapeutic target in patients with DCM.

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“…Several studies have investigated the enhancement and activity of IL-4 in DCM patients, and clarified the absence of detectable IL-4 in both myocardium and circulation of DCM patients [20,21]. Although IL-13 is a novel cytokine sharing a number of biological properties with those of IL-4, the differential functions of IL-13, but not of IL-4, have been recently reported in various inflammatory disease.…”

Section: Discussionmentioning

confidence: 99%

Serum markers of angiogenesis and myocardial ultrasonic tissue characterization in patients with dilated cardiomyopathy

Ohtsuka

Inoue

Hara

et al. 2005

European J of Heart Fail

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Background and aims: It has been proven that a disturbance in angiogenesis contributes to the progression of myocardial interstitial fibrosis in idiopathic dilated cardiomyopathy (DCM). This study was designed to evaluate the relationship between serum activity of angiogenic factors and myocardial ultrasonic tissue characterization in patients with DCM. Methods and results:We studied 30 patients with DCM and 15 healthy control subjects. Serum levels of vascular endothelial growth factor (VEGF), interleukin (IL)-4 and IL-13 were measured using enzyme-linked immunosorbent assay. We determined calibrated myocardial integrated backscatter (IB) as the value of myocardial interstitial fibrosis using ultrasonic tissue characterization and also quantified the magnitude of cyclic variations in IB (CV-IB). Serum levels of VEGF and IL-13 were significantly higher in patients with DCM than in control subjects (both Pb0.05). Calibrated IB was significantly higher and CV-IB was markedly lower in patients with DCM than in control subjects (both Pb0.01). In patients with DCM, the levels of IL-13 significantly correlated with calibrated IB (r=0.520, P=0.018). In addition, there was a significant negative correlation between levels of VEGF and CV-IB (r=À0.611, P=0.007). Conclusion: The increase in serum VEGF and IL-13 may be closely related to alterations in myocardial texture in DCM.

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Abnormal Cytokine Profiles in Patients with Idiopathic Dilated Cardiomyopathy and Their Asymptomatic Relatives

Cited by 18 publications

References 5 publications

Anti-inflammatory Cytokine Profile in Human Heart Failure

Anti-inflammatory Cytokine Profile in Human Heart Failure

Increased Matrix Metalloproteinase Activity and Selective Upregulation in LV Myocardium From Patients With End-Stage Dilated Cardiomyopathy

Serum markers of angiogenesis and myocardial ultrasonic tissue characterization in patients with dilated cardiomyopathy

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