Abnormal Cranial Magnetic Resonance Imaging Scans in Sickle-cell Disease

Defining stroke risk in children with sickle cell anaemia

“…Among the various clinical and laboratory parameters examined, the presence of silent infarcts on MRI was the strongest independent risk factor for stroke and was associated with a 14‐fold increased risk of developing overt stroke. These findings are consistent with a previous report showing subclinical MRI lesions as a risk factor for clinically apparent stroke in SCD (Kugler et al , 1993). Similar results were also found among untransfused children with SCA who were enrolled in the Stroke Prevention Trial in Sickle Cell anaemia (STOP) (Pegelow et al , 2001).…”

Defining stroke risk in children with sickle cell anaemia

“…Among the various clinical and laboratory parameters examined, the presence of silent infarcts on MRI was the strongest independent risk factor for stroke and was associated with a 14‐fold increased risk of developing overt stroke. These findings are consistent with a previous report showing subclinical MRI lesions as a risk factor for clinically apparent stroke in SCD (Kugler et al , 1993). Similar results were also found among untransfused children with SCA who were enrolled in the Stroke Prevention Trial in Sickle Cell anaemia (STOP) (Pegelow et al , 2001).…”

Relationship of Structural Magnetic Resonance Imaging, Magnetic Resonance Perfusion, and Other Disease Factors to Neuropsychological Outcome in Sickle Cell Disease

“…Our failure to find a significant relationship between MRI abnormalities and level of neuropsychological performance is consistent with the results of Kugler et al (1993) and Watkins et al (1998), but is contradicted by the findings of several studies (Armstrong et al, 1996;Bernaudin et al, 2000;Craft et al, 1993;Steen et al, 2003;Steen et al, 1998;Wang et al, 2001;Watkins et al, 1998) which found that silent stroke was associated with greater impairment in terms of performance. Several factors may potentially explain these discrepant findings.…”

“…The evidence regarding the effects of silent stroke on neuropsychological functioning in children with SCD is not entirely consistent. Kugler et al (1993) did not find significant differences on a variety of neuropsychological measures between a group of eight patients with abnormal MRI scans and a matched control group of eight patients with normal MRI scans. Similarly, Watkins et al (1998) found that patients with silent stroke did not differ significantly from patients with normal MRI scans and controls on index scores from the WISC-R, design memory and paired associate memory tasks, and the Wisconsin Card Sorting Test.…”

Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia

“…In the CSSCD participants, 83% of the children with overt strokes, but only 16% of those with SCI, had lesions that were at least 1.5 cm. 15 The CSSCD results supported early observations that the presence of SCI is a risk factor for additional neurologic injury, 19 with a higher risk of both clinical stroke (14-fold), and progressive silent infarction. Approximately 25% of the children with SCI, but only 2.5% of the children without SCI, had new and/or enlarging lesions on follow-up MRI scan.…”

Defining stroke risk in children with sickle cell anaemia

“…Among the various clinical and laboratory parameters examined, the presence of silent infarcts on MRI was the strongest independent risk factor for stroke and was associated with a 14‐fold increased risk of developing overt stroke. These findings are consistent with a previous report showing subclinical MRI lesions as a risk factor for clinically apparent stroke in SCD (Kugler et al , 1993). Similar results were also found among untransfused children with SCA who were enrolled in the Stroke Prevention Trial in Sickle Cell anaemia (STOP) (Pegelow et al , 2001).…”

Relationship of Structural Magnetic Resonance Imaging, Magnetic Resonance Perfusion, and Other Disease Factors to Neuropsychological Outcome in Sickle Cell Disease

“…Our failure to find a significant relationship between MRI abnormalities and level of neuropsychological performance is consistent with the results of Kugler et al (1993) and Watkins et al (1998), but is contradicted by the findings of several studies (Armstrong et al, 1996;Bernaudin et al, 2000;Craft et al, 1993;Steen et al, 2003;Steen et al, 1998;Wang et al, 2001;Watkins et al, 1998) which found that silent stroke was associated with greater impairment in terms of performance. Several factors may potentially explain these discrepant findings.…”

“…The evidence regarding the effects of silent stroke on neuropsychological functioning in children with SCD is not entirely consistent. Kugler et al (1993) did not find significant differences on a variety of neuropsychological measures between a group of eight patients with abnormal MRI scans and a matched control group of eight patients with normal MRI scans. Similarly, Watkins et al (1998) found that patients with silent stroke did not differ significantly from patients with normal MRI scans and controls on index scores from the WISC-R, design memory and paired associate memory tasks, and the Wisconsin Card Sorting Test.…”

Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia

“…In the CSSCD participants, 83% of the children with overt strokes, but only 16% of those with SCI, had lesions that were at least 1.5 cm. 15 The CSSCD results supported early observations that the presence of SCI is a risk factor for additional neurologic injury, 19 with a higher risk of both clinical stroke (14-fold), and progressive silent infarction. Approximately 25% of the children with SCI, but only 2.5% of the children without SCI, had new and/or enlarging lesions on follow-up MRI scan.…”

Defining stroke risk in children with sickle cell anaemia

“…Among the various clinical and laboratory parameters examined, the presence of silent infarcts on MRI was the strongest independent risk factor for stroke and was associated with a 14‐fold increased risk of developing overt stroke. These findings are consistent with a previous report showing subclinical MRI lesions as a risk factor for clinically apparent stroke in SCD (Kugler et al , 1993). Similar results were also found among untransfused children with SCA who were enrolled in the Stroke Prevention Trial in Sickle Cell anaemia (STOP) (Pegelow et al , 2001).…”

Relationship of Structural Magnetic Resonance Imaging, Magnetic Resonance Perfusion, and Other Disease Factors to Neuropsychological Outcome in Sickle Cell Disease

“…Our failure to find a significant relationship between MRI abnormalities and level of neuropsychological performance is consistent with the results of Kugler et al (1993) and Watkins et al (1998), but is contradicted by the findings of several studies (Armstrong et al, 1996;Bernaudin et al, 2000;Craft et al, 1993;Steen et al, 2003;Steen et al, 1998;Wang et al, 2001;Watkins et al, 1998) which found that silent stroke was associated with greater impairment in terms of performance. Several factors may potentially explain these discrepant findings.…”

“…The evidence regarding the effects of silent stroke on neuropsychological functioning in children with SCD is not entirely consistent. Kugler et al (1993) did not find significant differences on a variety of neuropsychological measures between a group of eight patients with abnormal MRI scans and a matched control group of eight patients with normal MRI scans. Similarly, Watkins et al (1998) found that patients with silent stroke did not differ significantly from patients with normal MRI scans and controls on index scores from the WISC-R, design memory and paired associate memory tasks, and the Wisconsin Card Sorting Test.…”

Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia

“…In the CSSCD participants, 83% of the children with overt strokes, but only 16% of those with SCI, had lesions that were at least 1.5 cm. 15 The CSSCD results supported early observations that the presence of SCI is a risk factor for additional neurologic injury, 19 with a higher risk of both clinical stroke (14-fold), and progressive silent infarction. Approximately 25% of the children with SCI, but only 2.5% of the children without SCI, had new and/or enlarging lesions on follow-up MRI scan.…”