Abnormal cortical brain integration of somatosensory afferents in ALS

Sangari, Sina; Giron, Alain; Marrelec, Guillaume; Marchand‐Pauvert, Véronique

doi:10.1016/j.clinph.2017.12.008

Cited by 14 publications

(6 citation statements)

References 126 publications

(205 reference statements)

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“…In addition, an initially increased SEP amplitude (enlarged N20 response) has been described in some patients, followed by a progressive reduction until its total loss, as the disease advanced to a locked-in state [ 73 ]. In line with such dynamic changes, other investigators found a decrease in sensory cortical excitability (reduction in early and late SEP cortical components: N20, P25, N30, N60, and P100), but in this study, the peripheral component of SEP (N9) was also diminished [ 74 ].…”

Section: Somatosensory Cortexsupporting

confidence: 84%

Sensory Involvement in Amyotrophic Lateral Sclerosis

Rubio

Herrando-Grabulosa

Navarro

2022

IJMS

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Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives.

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Section: Somatosensory Cortexsupporting

confidence: 84%

Sensory Involvement in Amyotrophic Lateral Sclerosis

Rubio

Herrando-Grabulosa

Navarro

2022

IJMS

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“…In addition to impaired cortical sensorimotor integration, increased response to sensory input at the spinal level may bring about a facilitatory, instead of inhibitory, response to the SAI paradigm in these patients. The same group in a more recent report also demonstrated depression of the late cortical components (N60, P100) of the median and ulnar SEPs . Because LAI activates widespread somatosensory cortical areas, such as the basal ganglia–thalamocortical loop, these late component SEP abnormalities seem compatible with our abnormal LAI findings.…”

Section: Discussionsupporting

confidence: 90%

“…The same group in a more recent report also demonstrated depression of the late cortical components (N60, P100) of the median and ulnar SEPs. 61 Because LAI activates widespread somatosensory cortical areas, such as the basal ganglia-thalamocortical loop, 30 these late component SEP abnormalities seem compatible with our abnormal LAI findings. Reduced inhibition in the SAI paradigm (P = 0.001) compared with controls was more prominent than the decreased inhibition observed in the LAI paradigm (P = 0.035) in ALS patients.…”

Section: Discussionsupporting

confidence: 72%

Impaired short‐ and long‐latency afferent inhibition in amyotrophic lateral sclerosis

et al. 2019

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Introduction: To test the hypothesis of impaired cholinergic activity in amyotrophic lateral sclerosis (ALS), we studied short‐ and long‐latency afferent inhibition (SAI and LAI). Methods: The ulnar nerve was stimulated at the wrist preceding transcranial magnetic stimulation (TMS), 21 ms for SAI and 200 ms for LAI, in 21 patients and 17 control subjects. Short‐interval intracortical inhibition (SICI) and cognitive function was assessed in ALS patients using automatic threshold tracking and the Montreal Cognitive Assessment (MoCA). Results: The SAI paradigm resulted in inhibition in all control subjects, whereas inhibition was observed in 13 of 21 (62%) patients. Mean SAI and LAI values were significantly reduced in ALS. No significant correlation existed between afferent inhibition and other neurophysiological data. The MoCA was normal in all but 1 patient. Discussion: LAI and SAI are both impaired in ALS, probably unrelated to increased cortical excitability or cognitive dysfunction. Muscle Nerve 59:699–704, 2019

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“…Interestingly, SEP differences did not significantly progress over the 180‐day follow‐up period, thus suggesting that, although frequent at diagnosis, sensory subclinical abnormalities are usually not as rapidly progressive as motor manifestations (Theys et al, 1999). Apart from the standard SEPs, components of late SEPs (N60, P100), which reflect on cortical pathways involved in cognitive–motor functions, were significantly depressed in ALS patients (Sangari, Giron, Marrelec, Pradat, & Marchand‐Pauvert, 2018).…”

Section: Clinical Evidence Supporting the Coexistence Of Sensory Disomentioning

confidence: 99%

Clinical and preclinical evidence of somatosensory involvement in amyotrophic lateral sclerosis

Riancho

Paz-Fajardo

Munáin

2020

British J Pharmacology

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Amyotrophic lateral sclerosis (ALS) is the most common motor neuron neurodegenerative disease. Although it has been classically considered as a disease limited to the motor system, there is increasing evidence for the involvement of other neural and non‐neuronal systems. In this review, we will discuss currently existing literature regarding the involvement of the sensory system in ALS. Human studies have reported intradermic small fibre loss, sensory axonal predominant neuropathy, as well as somatosensory cortex hyperexcitability. In line with this, ALS animal studies have demonstrated the involvement of several sensory components. Specifically, they have highlighted the impairment of sensory–motor networks as a potential mechanism for the disease. The elucidation of these “non‐motor” systems involvement, which might also be part of the degeneration process, should prompt the scientific community to re‐consider ALS as a pure motor neuron disease, which may in turn result in more holistic research approaches. LINKED ARTICLES This article is part of a themed issue on Neurochemistry in Japan. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.6/issuetoc

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Abnormal cortical brain integration of somatosensory afferents in ALS

Abstract: Late SEPs may provide new insights on abnormal cortical excitability affecting brain areas involved in cognitive-motor functions.

Cited by 14 publications

References 126 publications

Sensory Involvement in Amyotrophic Lateral Sclerosis

Sensory Involvement in Amyotrophic Lateral Sclerosis

Impaired short‐ and long‐latency afferent inhibition in amyotrophic lateral sclerosis

Clinical and preclinical evidence of somatosensory involvement in amyotrophic lateral sclerosis

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