Abnormal choroidal flow on optical coherence tomography angiography in central serous chorioretinopathy

Abstract

Importance Analysing choroidal flow in central serous chorioretinopathy (CSC) with novel device. Background To examine the abnormal morphology of choriocapillary flow with optical coherence tomography angiography (OCTA) according to the presence of subretinal fluid (SRF) in CSC. Design A hospital‐based retrospective study. Participants We analysed OCTA results of 68 eyes (68 patients) diagnosed as CSC with or without SRF (active and resolved CSC, respectively) at the Asan Medical Center. Methods We classified OCTA choriocapillary images into three pattern groups: mixed perfusion, hyper‐perfusion and normal perfusion. Data analysis included age, follow‐up duration, treatment modalities, number of treatments, subfoveal choroidal thickness and SRF height. Main Outcome Measures The relationship between CSC activity and choriocapillary pattern. Results Abnormal choroidal flow (mixed and hyper‐perfusion) was more frequently found in eyes with active CSC (100%) than resolved CSC (47.5%, P < 0.001). In active CSC eyes, mixed perfusion was predominant (71.4%), while hyper‐perfusion was predominant in those with resolved CSC (73.7%). Eyes with recently resolved CSC (SRF absorption present for <2 months) had abnormal choriocapillary flow more often than the remaining eyes with resolved CSC (83.3% vs 32.1%, P = 0.005). Resolved CSC eyes with abnormal choriocapillary flow demonstrated more recurrence than eyes with normal choriocapillary flow (42.1% vs 9.5%, P = 0.017). Conclusions and Relevance The pattern of choriocapillary flow abnormalities on OCTA can indicate CSC disease activity. Because eyes with resolved CSC showing abnormal choroidal flow have a high recurrence rate, they should be carefully followed‐up.

Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy: OCT Angiography Findings and Risk Factors

“…Moreover, the definitive diagnosis of CNV in CSC using dye-based angiography may be challenging due to overlap in clinical presentations and image findings. e advent of OCTA has enabled visualization of choriocapillaris and other vascular signal abnormalities at the choriocapillary level in CSC patients [11]. As in the previous study, we analyzed OCTA findings to detect CNV and divided patients into two groups (with or without CNV).…”

Rhegmatogenous retinal detachment induces more severe macular capillary changes than central serous chorioretinopathy

“…In the preliminary study, only age had a significant correlation with the DCP vascular density of CSC among the variables, including duration of macular detachment, refractive errors, SRF height and anti-vascular endothelial growth factor (VEGF) use, which were previously reported to be related to choroidal changes in CSC 17 , 18 . Therefore, comparing the results of CSC and RRD, age-matched groups were selected (42 eyes with CSC and 26 eyes with macula-off RRD) and analyzed to minimize age-related confounding factors.…”

Changes in the Choroidal Thickness following Intravitreal Bevacizumab Injection in Chronic Central Serous Chorioretinopathy

“…Considering the association of choroidal hyperpermeability and choroidal thickness, IVB may reduce choroidal hyperpermeability followed by a subsequent reduction in the choroidal thickness [ 16 ]. Abnormal choroidal flow as seen on OCT angiography is associated with CSC disease activity [ 21 ]. Our study demonstrated a significant reduction of SFCT and CRT following IVB, especially in the eyes with resolved CSC.…”