Abnormal carbohydrate metabolism in uraemia

Dzúrik, R; Hupková, Viera; Holomán, J; Valovičová, Eva

doi:10.1007/bf02082290

Cited by 11 publications

(2 citation statements)

References 8 publications

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“…The blood glucose of the three control dogs (not injected with methylguanidine) did not change significantly in the treatment period. D I S C U S S I O N The previously reported finding that uraemic sera inhibited glucose uptake by isolated diaphragms (Dzurik & Krajci-Lazary, 1967) and its utilization by normal human erythrocytes (Dzurik, Cachovanova & Valovichova, 1969;Balestri et al, 1970) has been confirmed (Figs. l a and 2a).…”

Section: Effect Of Methylguanidine On Blood Sugar Of Alloxan-diabeticmentioning

confidence: 72%

Effects of Uraemic Serum, Urea, Creatinine and Methylguanidine on Glucose Metabolism

et al. 1972

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S U M M A R Y1. Uptake of glucose by the rat diaphragm in vitro and utilization of glucose by human erythrocytes were inhibited by urea, creatinine and, to an even greater extent, by urea plus creatinine. Guanidine, methylguanidine and guanidinoacetic acid individually had a small enhancing effect on glucose uptake and utilization but collectively there may be an additive effect. Urate, p-cresol and p-cresylsulphate had no appreciable effects.2. Dialysis of uraemic patients greatly decreased, or abolished, the inhibitory effect of their sera on glucose uptake by hemidiaphragms.3. Administration of urea or creatinine lowered the oral glucose tolerance of patients with moderately impaired renal function.4. In ten normal dogs intravenous glucose tolerance curves were unchanged during methylguanidine administration, whereas in five dogs oral glucose tolerance curves became flattened. 5. Fasting blood glucose of five alloxan-diabetic dogs was decreased during administration of methylguanidine and increased again when administration was discontinued.

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Section: Effect Of Methylguanidine On Blood Sugar Of Alloxan-diabeticmentioning

confidence: 72%

Effects of Uraemic Serum, Urea, Creatinine and Methylguanidine on Glucose Metabolism

et al. 1972

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“…This diabetic-like condition seems to be caused by a reduced glucose oxidation in 'peripheral' tissues [10. 19], Indeed, an increased con centration of glucose has been observed in the muscle of uremic patients [12], The origin of such a decrease of glucose tolerance is unknown, though some alterations of anaerobic glycolysis [8,9,16] or some changes in the activity of the citric acid cycle [3, 4. 13, 17, 18] seem to be partly responsible.…”

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confidence: 99%

Pyruvate Tolerance Test in Chronic Uremic Patients

Campanacci¹,

Guarnieri²,

Faccini³

et al. 1973

Nephron

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After intravenous pyruvate administration, the rate of decay of the blood pyruvate was significantly lower in the chronic uremic patients than in the healthy subjects. This difference could not be ascribed to a reduced renal excretion of pyruvate. Lower blood 2-oxoglutarate levels were found during the test in chronic uremic patients. The impaired glucose tolerance observed in chronic uremia could in part depend on a reduced pyruvate oxidation in the citric acid cycle.

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Middle molecule hypothesis and short dialysis

Buzio¹,

Barani²

1987

Short Dialysis

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Abnormal carbohydrate metabolism in uraemia

Cited by 11 publications

References 8 publications

Effects of Uraemic Serum, Urea, Creatinine and Methylguanidine on Glucose Metabolism

Effects of Uraemic Serum, Urea, Creatinine and Methylguanidine on Glucose Metabolism

Pyruvate Tolerance Test in Chronic Uremic Patients

Middle molecule hypothesis and short dialysis

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