Abnormal Brain Activity in Social Reward Learning in Children with Autism Spectrum Disorder: An fMRI Study

Choi, Uk-Su; Kim, Sun‐Young; Sim, Hyeon Jeong; Lee, Seo-Young; Park, Sung‐Yeon; Jeong, Joon-Sup; Seol, Kyeong In; Yoon, Hyo-Woon; Jhung, Kyungun; Park, Jee-In; Cheon, Keun‐Ah

doi:10.3349/ymj.2015.56.3.705

Cited by 27 publications

(31 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, significant hyper-connectivity was identified between the left dorsal dysgranular insula and the STG.L in ASD. In line with the hyper-connectivity of our result, previous studies showed increased activity during social reward learning (Choi et al, 2015 ), sentence comprehension task (Just et al, 2004 ), and facial emotion processing (Dalton et al, 2008 ), as well as increased gray matter volume in STG.L in ASD (Waiter et al, 2004 ). Moreover, our finding of functional hyper-connectivity is also supported by the positive correlation with the ADI-R social scores, which implied that children with greater connectivity exhibited more severe impairment in the social domain.…”

Section: Discussionsupporting

confidence: 92%

Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders

Wang

Zhang

et al. 2018

Front. Neurosci.

View full text Add to dashboard Cite

Some studies identified hypo-connectivity, while others showed hyper-connectivity of the insula in the autism spectrum disorders (ASD). These contradictory findings leave open the question of whether and to what extent functional connectivity of the insula is altered and how functional connectivity of the insula is associated with the severity of ASD. A newly emerging insular atlas that comprises multiple functionally differentiated subregions provides a new framework to interpret the functional significance of insular findings and uncover the mechanisms underlying the severity of ASD. Using the new insular atlas, the present study aimed to investigate the distinct functional connectivity of the insular subregions and their associations with ASD severity in a cohort of 49 children with ASD and 33 typically developing (TD) subjects. We found that compared with TD group, the ASD group showed different connectivity patterns in the left ventral agranular insula, right ventral dysgranular and granular insula, and dorsal dysgranular insula, characterized by significant hyper-connectivity and/or hypo-connectivity with special brain regions. Furthermore, both the hypo-connectivity and hyper-connectivity patterns of the insular subregions were significantly associated with the severity of ASD symptoms. Our research demonstrated distinct functional connectivity patterns of the insular subregions and emphasized the importance of the subdivisions within the insula to the potential impact of functional difference in children with ASD. Moreover, these results might help us to better understand the mechanisms underlying the symptoms in children with ASD and might elucidate potential biomarkers for clinical applications.

show abstract

Section: Discussionsupporting

confidence: 92%

Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders

Wang

Zhang

et al. 2018

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Original ture with unreported relevant data from publications on related disorders or tasks. 31,34,45 The existing literature included conflicting results that were difficult to compare owing to varied sample age, different correction methods, and region of interest analyses, which inherently introduce bias. 46 This metaanalysis addressed these issues and revealed that ASD groups showed reward circuitry hypoactivation for both social and nonsocial rewards.…”

Section: Evaluation Of the Social Motivation Hypothesis Of Autismmentioning

confidence: 99%

Evaluation of the Social Motivation Hypothesis of Autism

et al. 2018

View full text Add to dashboard Cite

Individuals with ASD show atypical processing of social and nonsocial rewards. Findings support a broader interpretation of the social motivation hypothesis of ASD whereby general atypical reward processing encompasses social reward, nonsocial reward, and perhaps restricted interests. This meta-analysis also suggests that prior mixed results could be driven by sample age differences, warranting further study of the developmental trajectory for reward processing in ASD.

show abstract

“…Consistent with this hypothesis, numerous psychological studies have shown diminished sensitivity to the positive reward value of social stimuli in subjects with ASD (Scott‐Van Zeeland et al , ; Chevallier et al , ; Lin et al , ; Sasson et al , ; Dubey et al , ; Kim et al , ). Accordingly, electrophysiological (Stavropoulos and Carver, ; Gonzalez‐Gadea et al , ) and pupillary (Sepeta et al , ) responses as well as neural activation in brain areas involved in reward anticipation and/or processing (notably PFC and NAc) (Scott‐Van Zeeland et al , ; Kohls et al , ; Assaf et al , ; Kohls et al , ; Richey et al , ; Choi et al , ; Leung et al , ) are diminished in ASD patients presented with social stimuli (Figure ). Of note, subjects with ASD also display hypo‐activated NAc and caudate putamen (CPu) while anticipating negative social reinforcement (Damiano et al , ) and diminished activity in the social brain circuitry (including PFC and amygdala) in response to social touch (Kaiser et al , ).…”

Section: Evidence For Blunted Reward Processes In Autism Spectrum Dismentioning

confidence: 99%

μ opioid receptor, social behaviour and autism spectrum disorder: reward matters

Pellissier

Gandía

Laboute

et al. 2017

British J Pharmacology

View full text Add to dashboard Cite

The endogenous opioid system is well known to relieve pain and underpin the rewarding properties of most drugs of abuse. Among opioid receptors, the μ receptor mediates most of the analgesic and rewarding properties of opioids. Based on striking similarities between social distress, physical pain and opiate withdrawal, μ receptors have been proposed to play a critical role in modulating social behaviour in humans and animals. This review summarizes experimental data demonstrating such role and proposes a novel model, the μ opioid receptor balance model, to account for the contribution of μ receptors to the subtle regulation of social behaviour. Interestingly, μ receptor null mice show behavioural deficits similar to those observed in patients with autism spectrum disorder (ASD), including severe impairment in social interactions. Therefore, after a brief summary of recent evidence for blunted (social) reward processes in subjects with ASD, we review here arguments for altered μ receptor function in this pathology. This article is part of a themed section on Emerging Areas of Opioid Pharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.14/issuetoc.

show abstract

Abnormal Brain Activity in Social Reward Learning in Children with Autism Spectrum Disorder: An fMRI Study

Cited by 27 publications

References 25 publications

Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders

Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders

Evaluation of the Social Motivation Hypothesis of Autism

μ opioid receptor, social behaviour and autism spectrum disorder: reward matters

Contact Info

Product

Resources

About