Abnormal brain activation during threatening face processing in schizophrenia: A meta-analysis of functional neuroimaging studies

Neural correlates of emotional processing in psychosis risk and onset – A systematic review and meta-analysis of fMRI studies

“…Several meta-analyses of functional magnetic resonance (fMRI) and positron emission tomography (PET) studies showed lower activation to emotional stimuli compared to neutral stimuli in schizophrenia patients relative to healthy controls in several brain regions ( Kohler et al, 2010 ; Anticevic et al, 2012 ; Taylor et al, 2012 ; Li et al, 2010 ). Such finding was most consistently reported for the bilateral amygdala in relation to aversive stimuli ( Anticevic et al, 2012 ) as well as to facial emotion expressions (across valences, analysing threatening expressions only, or isolating implicit and explicit processing) ( Taylor et al, 2012 ; Li et al, 2010 ; Dong et al, 2018 ). Under-recruitment of other regions to emotion-related stimuli was also reported, such as in the right superior frontal gyrus ( Li et al, 2010 ), hippocampus, early visual processing regions, frontal cortices ( Taylor et al, 2012 ) and fusiform gyrus ( Dong et al, 2018 ).…”

“…Such finding was most consistently reported for the bilateral amygdala in relation to aversive stimuli ( Anticevic et al, 2012 ) as well as to facial emotion expressions (across valences, analysing threatening expressions only, or isolating implicit and explicit processing) ( Taylor et al, 2012 ; Li et al, 2010 ; Dong et al, 2018 ). Under-recruitment of other regions to emotion-related stimuli was also reported, such as in the right superior frontal gyrus ( Li et al, 2010 ), hippocampus, early visual processing regions, frontal cortices ( Taylor et al, 2012 ) and fusiform gyrus ( Dong et al, 2018 ). These meta-analyses also identified aspects of study design that may underlie region-specific differences across studies; for instance, implicit or explicit task paradigms may recruit disparate brain networks ( Li et al, 2010 ) and comparison to a neutral condition may yield more robust results than a comparison across emotion conditions ( Anticevic et al, 2012 ).…”

Neural Correlates of Auditory Verbal Hallucinations in Schizophrenia and the Therapeutic Response to Theta-Burst Transcranial Magnetic Stimulation

“…22–24 Such rs-fMRI studies yielded useful information to enhance an understanding of the neurobiological mechanisms underlying AVH. However, most of them were cross-sectional 6,25,26 and rarely associated with novel therapies, such as rTMS.…”

Brain imaging features in schizophrenia with co‐occurring auditory verbal hallucinations and depressive symptoms—Implication for novel therapeutic strategies to alleviate the reciprocal deterioration

“…In addition, the abnormal density of functional connections in the prefrontal lobe between depression and schizophrenia was a common feature between the two diseases (Han et al., 2019). Using the Granger causality model technique, abnormal structural connections between the prefrontal lobe, thalamus, and cerebellum were found to be a common feature of depression and schizophrenia (Dong et al., 2018). Two studies have reported WM damage in patients with depression, schizophrenia, and bipolar disorder (Dong et al., 2018; Koshiyama et al., 2019).…”

“…Using the Granger causality model technique, abnormal structural connections between the prefrontal lobe, thalamus, and cerebellum were found to be a common feature of depression and schizophrenia (Dong et al., 2018). Two studies have reported WM damage in patients with depression, schizophrenia, and bipolar disorder (Dong et al., 2018; Koshiyama et al., 2019). In 2018, it was observed that abnormalities of regional functional connectivity, primary in the bilateral orbitofrontal lobe, are a common brain characteristic of schizophrenia, depression, and bipolar disorder (Wei et al., 2017).…”