Abnormal brachial artery flow-mediated vasodilation in young adults with major depression

Rajagopalan, Sanjay; Brook, Robert D.; Rubenfire, Melvyn; Pitt, Elaine; Young, Elizabeth A.; Pitt, Bertram

doi:10.1016/s0002-9149(01)01623-x

Cited by 220 publications

(166 citation statements)

References 17 publications

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“…Studies investigating the association between depression and arteriosclerosis have used a variety of indexes for vascular function (Lavoie et al 2010;Oulis et al 2010;Paranthaman et al 2010;Rajagopalan et al 2001;Rybakowski et al 2006;Sherwood et al 2005;Tiemeier et al 2003). Irrespective of these different outcome measures, all studies unanimously have shown depressed individuals to have impaired endothelial function or increased arterial stiffness.…”

Section: Existing Evidence On Association Between Depression and Subcmentioning

confidence: 99%

Depression, Vascular Conditions and Chronicity

Seldenrijk¹,

Vogelzangs²,

Oppen³

et al. 2013

Psychiatric Disorders - New Frontiers in Affective Disorders

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Section: Existing Evidence On Association Between Depression and Subcmentioning

confidence: 99%

Depression, Vascular Conditions and Chronicity

Seldenrijk¹,

Vogelzangs²,

Oppen³

et al. 2013

Psychiatric Disorders - New Frontiers in Affective Disorders

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“…Recent studies allude to a potential role of nitric oxide (NO) in the relationship between MD and CV risk as well as an effect of antidepressants on NO production (Rajagopalan et al, 2001;Finkel et al, 1996;Lara et al, 2003a). NO produced from either the endothelium or from platelets plays a major role in CV regulation and CV pathology.…”

Section: Introductionmentioning

confidence: 99%

Alteration of Decreased Plasma NO Metabolites and Platelet NO Synthase Activity by Paroxetine in Depressed Patients

Chrapko

Jurasz

Radomski

et al. 2005

Neuropsychopharmacol

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Although major depression (MD) and cardiovascular disease (CVD) have been conclusively linked in the literature, the mechanism associating MD and CVD is yet undetermined. The purpose of this paper is to further investigate a potential mechanism involving nitric oxide (NO) and to examine the effect of the selective serotonin reuptake inhibitor paroxetine on NO production by both platelets and the endothelium. In total, 17 subjects with MD and 12 healthy controls (HCs) with no known history of cardiovascular illness completed the study. Paroxetine was administered to both the MD patients and HCs over an 8-week period, and then medication was discontinued. Blood samples were taken at various times throughout paroxetine treatment and after discontinuation. Plasma NO metabolite (NOx) levels were measured by a chemiluminescence method. Platelet endothelial NO synthase (eNOS) activity was examined through the conversion of L-[14 C]arginine to L-[ 14 C]citrulline. Data were analyzed using t-tests and a linear mixed effects model. Baseline levels of both plasma NOx and platelet NOS activity were significantly lower in subjects with MD compared to HCs. Throughout paroxetine treatment, plasma NOx levels increased in both HCs and MD patients. However, platelet eNOS activity decreased in HCs, while no statistically significant change was evidenced in MD patients. These data suggest that, in MD patients, decreased peripheral production of NO, a potential contributor to increased cardiovascular risk, is modified by administration of the antidepressant paroxetine.

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“…9 A rapidly growing body of work has also demonstrated in vivo vascular changes in depressive disorder. Thus, endothelial dysfunction occurs in the large arteries of untreated patients 10 and those taking antidepressant therapy. 11 Compared with matched participants without depression there is also a greater prevalence 12 and incidence 13 of increased carotid intima-media thickness and an increase in aortic pulse wave velocity, 14 even after adjustment for traditional risk factors.…”

mentioning

confidence: 99%

Cerebrovascular Damage in Late-Life Depression Is Associated With Structural and Functional Abnormalities of Subcutaneous Small Arteries

et al. 2010

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Abstract-Late-life depression is increasingly viewed as a vascular illness because of patients exhibiting characteristic white matter brain lesions and in vivo large artery endothelial dysfunction. However, the "vascular depression" hypothesis pertains to the microvasculature, and this circulation has not been studied in this context. Our objective was to examine structure and function of small subcutaneous arteries in patients with late-life depression. Thus, 16 patients aged 71.8Ϯ4.0 years with late-life depression were compared with 15 control participants aged 72.1Ϯ5.9 years. There were similar cardiovascular profiles between the 2 groups. All of the participants underwent MRI brain scans and subcutaneous gluteal fat biopsy from which small arteries were isolated and studied using pressure myography. Cerebral microvascular damage in depressed patients was confirmed by assessment of basal ganglia Virchow-Robin space scores (depressed patients 3.9Ϯ1.7 versus controls: 2.5Ϯ1.6; Pϭ0.01). Contractility to norepinephrine was equivalent in both groups, but relaxation of the small arteries to acetylcholine was significantly reduced in depressed patients (84.0Ϯ4.0%) compared with control participants (96.0Ϯ1.4%; Pϭ0.012). This difference in arterial relaxation was reduced but not entirely eliminated when NO synthase was inhibited. Depressed patients also exhibited hypertrophic wall growth with an increase in medial cross-sectional area (Pϭ0.035, multiple ANOVA and wall thickness; Pϭ0.04, multiple ANOVA).In conclusion, despite similar cardiovascular profiles, depressed patients with cerebral microvascular damage show abnormalities of subcutaneous small artery structure and function. (Hypertension. 2010;56:734-740.)

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Abnormal brachial artery flow-mediated vasodilation in young adults with major depression

Cited by 220 publications

References 17 publications

Depression, Vascular Conditions and Chronicity

Depression, Vascular Conditions and Chronicity

Alteration of Decreased Plasma NO Metabolites and Platelet NO Synthase Activity by Paroxetine in Depressed Patients

Cerebrovascular Damage in Late-Life Depression Is Associated With Structural and Functional Abnormalities of Subcutaneous Small Arteries

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