Abnormal BMI in Male and/or Female Partners Are Deleterious for Embryonic Development and Pregnancy Outcome During ART Process: A Retrospective Study

Abstract

ObjectiveTo investigate the effect of BMI in male and/or female partners on embryo development and clinical pregnancy outcome during ART.MethodsData of 11,130 cycles between January 2018 and December 2020 were retrospectively analyzed. They were divided into Group A, B, C, and D based on couples’ BMI values, also were divided into Group I, II, III and IV in IVF cycles and Group i, ii, iii, and iv in ICSI cycles. After grouping, inter-group indicators comparisons and logistic regression analysis were performed.ResultsIn IVF cycles, CPR in Group I and Group III were higher than Group IV. In Group III, it was higher than Group II. The AR in Group IV was higher, but the LBR was lower than Group I, Group II, and Group III. Logistic regression analysis results suggested that AR in Group IV was higher than that in Group I in IVF cycles, whereas LBR was lower.In ICSI cycles, high-quality embryo rate in Group i and Group ii were both higher than that in Group iii and Group iv. The CPR in Group i was higher than Group ii and Group iv, and in Group iii was higher than Group ii and Group iv. The AR in Group i was lower than Group iii and Group iv, and AR in Group ii was lower than Group iv. LBR, in Group I it was higher than Group ii, Group iii, and Group iv. Logistic regression analysis results suggested CPR in Group ii was significantly lower than that in Group i. AR in Group iii was considerably higher than that in Group i. LBR in Group ii and Group iv were significantly lower than that in Group i.ConclusionFemale higher BMI was not conducive to the formation of high-quality embryos in ICSI cycle. Female and/or male BMI affected AR and LBR more than CPR not only in IVF cycles, but also in ICSI cycles.

Is the length of time between endometrial scratching and embryo transfer important for pregnancy success? An observational study

“…However, Potdar et al 8 and Nastri et al 13 did not describe how type of endometrial injury or the length of time between endometrial injury and embryo transfer may influence blastocyst implantation. We believe that endometrial biopsy is the preferred approach because a biopsy helps identify certain microscopic endometrial causes of infertility, such as chronic endometritis (CE), which is a condition involving the breakdown of the peaceful coexistence between microorganisms and the host immune system in the endometrium 16,17 . Unfortunately, in most cases, CE produces no noticeable signs or only mild symptoms.…”

“…Therefore, this entity may be neglected by gynecologists and pathologists due to its mild clinical manifestations and the time-consuming microscopic examinations necessary for its diagnosis. Based on diagnostic criteria for CE, the prevalence of this condition is approximately 11.1% in the general population 18 , and it is highly prevalent among infertile women [14][15][16][17][18] .…”

Maternal age, obesity and hyperglycaemia are associated with a delay in preimplantation development in a mouse model of type 2 diabetes

“…They respond poorly to induction of ovulation, require higher doses of gonadotropins and longer treatment courses for follicular development and ovulatory cycles [40]. When focusing on their blastocyst quality, high BMI is not associated with low embryo quality, though implantation rate is reduced [41][42][43]. Type 2 diabetes is most frequently associated with obesity.…”

Obesity: A Doorway to a Molecular Path Leading to Infertility

“…There are several studies that suggest that male BMI above the normal range may be related to a reduced rate of success following the use of ART like IVF and intracytoplasmic sperm injection (ICSI) [ 12 , 224 , 225 ]. A study performed by Anifandis et al showed that the effect of paternal BMI on the quality of the embryo and outcome of IVF was greater than the parameters of semen analysis [ 226 ].…”