Abnormal Blood Levels of Trace Elements and Metals, DNA Damage, and Breast Cancer in the State of Kuwait

Saleh, Farid; Behbehani, A.; Asfar, Sami; Khan, Islam Enver; Ibrahim, Ghada

doi:10.1007/s12011-010-8724-z

Cited by 36 publications

(27 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A similar association has been observed for chromium [57], and copper [50,57]. However, a study of breast cancer patients in Kuwait found significantly lower blood concentrations of zinc and copper among stage I breast cancer patients when compared to controls, though the authors noted that prior studies typically found an increase in blood copper among breast cancer patients [58]. In another study, significantly lower concentrations of zinc in hair were also reported among breast cancer patients than among healthy individuals [50].…”

Section: Environmental Exposuressupporting

confidence: 61%

“…There is consistent evidence in the literature that high selenium levels are associated with decreased risk for breast cancer [58,62]. There is also some evidence that magnesium and calcium levels are lower in breast cancer patients [50,57,63].…”

Section: Environmental Exposuresmentioning

confidence: 74%

“…One contaminant that has emerged in the literature as being associated with breast cancer risk is cadmium [53][54][55][56][57][58][59], with one study finding a two-fold increase in risk among women in the highest versus lowest quartile of urine cadmium level [56]. Another study found a positive association between dietary cadmium intake and risk of breast cancer in postmenopausal women [55].…”

Section: Environmental Exposuresmentioning

confidence: 99%

See 2 more Smart Citations

Cultural and Environmental Factors of Triple-Negative Breast Carcinomas

Whitesell¹,

Al-Najar²,

Bowser³

et al. 2014

CRJ

View full text Add to dashboard Cite

Breast cancer is a leading cause of cancer death in the world. The triple-negative breast cancer subtype is associated with poorer prognosis than hormone receptor-positive subtypes and is more prevalent among African Americans than white, European Americans. The goal of this study has been to elucidate environmental, hormonal, and cultural factors that may be contributing to this disparity in an effort to identify modifiable risk factors and improve triple-negative breast cancer outcomes. Factors that may impact risk include vitamin D defiency, hormonal factors, environmental and dietary exposure, radiation exposure, and obesity. These factors may disproportionately affect African American women as a result of socioeconomic status, lifestyle, and cultural norms. Furthermore, disparities in prognosis may be compounded by barriers such as access to healthcare, prevention education, and perceptions of healthcare. Both biological and sociocultural factors impacting risk must be addressed in order for future prevention and treatment efforts to succeed.

show abstract

Section: Environmental Exposuressupporting

confidence: 61%

Section: Environmental Exposuresmentioning

confidence: 74%

Section: Environmental Exposuresmentioning

confidence: 99%

See 1 more Smart Citation

Cultural and Environmental Factors of Triple-Negative Breast Carcinomas

Whitesell¹,

Al-Najar²,

Bowser³

et al. 2014

CRJ

View full text Add to dashboard Cite

show abstract

“…En algunos estudios se ha sugerido que el cadmio induce daño en el ADN como resultado de la generación de radicales libres (58). En otro estudio se señaló la relación entre el cáncer de mama, las frecuencias de micronúcleos y los niveles elevados de cadmio en las muestras de sangre periférica de los pacientes afectados (59). La exposición crónica al cadmio en los seres humanos, causa una amplia variedad de efectos adversos relacionados con su toxicidad, incluido el cáncer de pulmón, el cáncer de próstata, la insuficiencia y la disfunción renal (52).…”

Section: Discussionunclassified

Efectos genotóxicos en población humana asociados a metales pesados en la región de La Mojana, Colombia, 2013

Calao

Marrugo

2015

biomedica

View full text Add to dashboard Cite

Contribución de los autores:Clelia Rosa Calao: ejecución del estudio en campo y realización de pruebas biológicas (ensayo cometa), análisis de resultados y redacción del artículo José Luis Marrugo: concepción y diseño del estudio, revisión del manuscrito en cuanto a la dinámica de la contaminación con metales pesados y su relación con la salud pública como aplicación de la vigilancia ambiental Introducción. En Colombia, la minería es una actividad económica importante; sin embargo, genera grandes cantidades de residuos que contienen elementos potencialmente tóxicos, como los metales pesados, que contaminan los ecosistemas y ponen en riesgo la salud humana. La región de La Mojana es una de las zonas más ricas en biodiversidad del planeta y se ha visto sometida a procesos de contaminación muy relacionados con la minería de oro que se desarrolla en sus alrededores. Objetivo. Evaluar la genotoxicidad en una población expuesta a residuos de metales pesados en la región de La Mojana. Materiales y métodos. Se evaluaron los efectos genotóxicos y su relación con la concentración de metales pesados (mercurio, cadmio y plomo) en muestras de sangre de la población expuesta y el grupo de control. El grupo expuesto lo conformaron habitantes de los municipios de Guaranda, Sucre, Majagual y San Marcos; en el grupo de control se incluyó a habitantes del municipio de Montería. Se determinó el daño en el ADN mediante el ensayo cometa en condiciones alcalinas. Las concentraciones de mercurio se establecieron mediante espectrometría de absorción atómica con vapor frío, en tanto que las de cadmio y plomo se determinaron por espectrometría de absorción atómica en horno de grafito. Resultados. Las concentraciones de los metales sobrepasaron los límites permitidos por la Organización Mundial de la Salud. Se evidenciaron efectos genotóxicos posiblemente asociados a la presencia de los metales en la sangre. Se encontraron asociaciones significativas (p<0,05) entre la presencia de mercurio y de cadmio, y el daño en el ADN. Conclusión. Estos resultados sugieren que el daño genético registrado en pobladores de la región de La Mojana, Colombia, puede estar asociado a la presencia de los metales estudiados en las muestras de sangre. Genotoxic effects in a human population exposed to heavy metals in the region of La Mojana, Colombia, 2013 Introduction: Mining is an economically important activity in Colombia which generates large quantities of residues containing potentially toxic elements such as heavy metals. These contaminate ecosystems and place human health at risk. La Mojana lies within one of the most biodiversity-rich zones on Earth and has been subjected to processes of contamination closely related to gold mining activities in the surrounding areas. Objective: To evaluate genotoxicity in the population of La Mojana region exposed to heavy metals. Materials and methods: Genotoxic effects and their relationship with concentrations of heavy metals (mercury, cadmium and lead) in blood were evaluated among an exposed population and a contr...

show abstract

“…1,2 In India, breast cancer is the most common cancer among women in many regions and has overtaken cervix cancer. 3 Presently the percentage of breast cancer among the male population has risen above 2 % of all cancers. 4,5 There are various risk factors for breast cancer which include estrogenic and reproductive factors, hereditary factor, dietary factor, environmental factors and also life style of the individual.…”

Section: Introductionmentioning

confidence: 99%

Role of Heavy Metals (Lead and Cadmium) in Malignant Breast Tumors

Hilal¹,

Ismail²,

Akhtar³

et al. 2013

J Pharm Sci Innov.

View full text Add to dashboard Cite

Heavy metals as environmental pollutants have been recognized to have a role in the induction of malignant human growths. Recently, certain heavy metals have shown a close association with breast cancers. The objective of this study was to assess the concentration of lead and cadmium in malignant breast tumors and the normal breast tissue of the same individual. Lead and Cadmium concentration was determined in the breast tissue samples of 30 malignant breast tumor patients. Two samples of breast tissue from each patient, i.e. diseased tissue and normal tissue (from the same breast of the same patient) were taken during the lumpectomy or mastectomy procedure, for analysis by atomic absorption spectrophotometer. The present study showed a highly significant increase in Lead (11.8 ± 2.6) (P < 0.001) and Cadmium (6.5 ± 1.9) (P < 0.001) concentrations in malignant breast tumor tissues as compared to their corresponding normal tissues (Lead 4.4 ± 2.7 and Cadmium 1.9 ± 1.1). We concluded that Lead and Cadmium have a significant role in the causation of malignant breast tumors and can be a potent diagnostic marker of the disease process. Keywords: Lead, Cadmium, Malignant Breast Tumor, Atomic absorption spectrophotometer. INTRODUCTIONBreast diseases are very common all over the world; especially malignant breast tumors are common in the western world. Breast cancer ranks second to all cancers in the American women and incidence of female breast cancer has risen world wide in the recent decade.1,2 In India, breast cancer is the most common cancer among women in many regions and has overtaken cervix cancer.3 Presently the percentage of breast cancer among the male population has risen above 2 % of all cancers.

show abstract

Abnormal Blood Levels of Trace Elements and Metals, DNA Damage, and Breast Cancer in the State of Kuwait

Cited by 36 publications

References 76 publications

Cultural and Environmental Factors of Triple-Negative Breast Carcinomas

Cultural and Environmental Factors of Triple-Negative Breast Carcinomas

Efectos genotóxicos en población humana asociados a metales pesados en la región de La Mojana, Colombia, 2013

Role of Heavy Metals (Lead and Cadmium) in Malignant Breast Tumors

Contact Info

Product

Resources

About