Abnormal B Cell Differentiation in Primary Sjögren's Syndrome Results in a Depressed Percentage of Circulating Memory B Cells and Elevated Levels of Soluble CD27 That Correlate with Serum IgG Concentration

Bohnhorst, Janne Ø.; Bjørgan, Marie B.; Thöen, J.; Jönsson, Roland; Natvig, J. B.; Thompson, Keith M.

doi:10.1006/clim.2002.5199

Cited by 79 publications

(77 citation statements)

References 36 publications

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“…This is supported by recent observations that varying levels of various immune markers, many belonging to the adaptive immune system, are influenced by nonheritable factors such as the environment (27). High blood concentrations of CXCL13, sTNF-R1, sCD23, sCD27, and sCD30 have been associated to disease states related to immune system activation, such as autoimmune diseases, hepatitis, and HIV infection (28)(29)(30)(31)(32). Another plausible explanation for the observed marker increase over time may thus be longstanding chronic inflammation, or infection leading to sustained B-or T-cell activation, and ultimately resulting in lymphoma development (33).…”

Section: Discussionmentioning

confidence: 68%

Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis

et al. 2017

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The B-cell activation markers CXCL13, sCD23, sCD27, and sCD30 are associated with future lymphoma risk. However, a lack of information about the individual dynamics of markerdisease association hampers interpretation. In this study, we identified 170 individuals who had donated two prediagnostic blood samples before B-cell lymphoma diagnosis, along with 170 matched cancer-free controls from the Northern Sweden Health and Disease Study. Lymphoma risk associations were investigated by subtype and marker levels measured at baseline, at the time of the repeated sample, and with the rate of change in the marker level. Notably, we observed strong associations between CXCL13, sCD23, sCD27, and sCD30 and lymphoma risk in blood samples collected 15 to 25 years before diagnosis. B-cell activation marker levels increased among future lymphoma cases over time, while remaining stable among controls. Associations between slope and risk were strongest for indolent lymphoma subtypes. We noted a marked association of sCD23 with chronic lymphocytic leukemia (OR Slope ¼ 28, P trend ¼ 7.279 Â 10 À10

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Section: Discussionmentioning

confidence: 68%

Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis

et al. 2017

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“…Both differences might reflect an abnormality in activation status of the naive subpopulation. Thus, disturbed B cell differentiation, activation, and/or (re)circulation between immune compartments may contribute to the disturbed B cell homeostasis in primary SS (10,30). Detailed understanding of the impact of chemokines and their cognate receptors, including their regulation, may allow the development of future therapeutic interventions in primary SS, a disease unresponsive to classic immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome

Hansen¹,

Reiter²,

Ziprian³

et al. 2005

Arthritis & Rheumatism

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Objective. To assess whether abnormal chemokine receptor expression and/or abnormal responsiveness to the cognate ligands might underlie some of the disturbances in B cell homeostasis characteristic of primary Sjögren's syndrome (SS).Methods. Chemokine receptor expression by CD27؊ naive and CD27؉ memory B cells from patients with primary SS and healthy control subjects was analyzed using flow cytometry, single-cell reverse transcriptase-polymerase chain reaction (RT-PCR), and migration assays.Results. In contrast to healthy subjects, significantly higher expression of both surface CXCR4 and CXCR4 messenger RNA (mRNA) was seen in peripheral blood B cells from patients with primary SS. These differences were most prominent in CD27؊ naive B cells (P < 0.0006). In addition, significantly higher frequencies of CD27؊ naive B cells from patients with primary SS expressed mRNA for the inhibitory regulator of G protein signaling 13 (P ‫؍‬ 0

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“…Moreover, the formation of ectopic GCs carries a higher risk of developing B cell lymphoma [2][3][4]. The selection of mutated high-affinity GC B cells depends on the restimulation with antigen arrayed on follicular dendritic cells and the provision of help by follicular helper T (T FH ) cells [5].…”

Section: Introductionmentioning

confidence: 99%

Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome

Szabó

Papp

Baráth

et al. 2013

Clinical Immunology

140

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Abnormal B Cell Differentiation in Primary Sjögren's Syndrome Results in a Depressed Percentage of Circulating Memory B Cells and Elevated Levels of Soluble CD27 That Correlate with Serum IgG Concentration

Cited by 79 publications

References 36 publications

Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis

Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis

Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome

Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome

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