Abnormal Amygdala-Prefrontal Effective Connectivity to Happy Faces Differentiates Bipolar from Major Depression

Almeida, Jorge; Versace, Amelia; Mechelli, Andrea; Hassel, Stefanie; Quevedo, Karina; Kupfer, David J.; Phillips, Mary L.

doi:10.1016/j.biopsych.2009.03.024

Cited by 279 publications

(246 citation statements)

References 52 publications

(51 reference statements)

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“…An alternative interpretation of these results could be greater abnormal regulation processes in BD. Different studies reported changes in prefrontal regulation in affective disorders that differentiates UD and BD, particular connectivity patterns between the orbital frontal cortex and the amygdala (Almeida et al, 2009;Robinson et al, 2008). Similar processes could be in play in the context of reward processing, meaning that the reported result of a most blunted NAcc activity is not necessarily related to reward outcome, but with regulation abnormalities that take part before the outcome processing.…”

Section: Reward Processing In Ud and Bdmentioning

confidence: 98%

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Redlich

Dohm

Grotegerd

et al. 2015

Neuropsychopharmacol

139

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Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge. The identification of neurobiological markers may help to differentiate these disorders, particularly during depressive episodes. This cross-sectional study, including 33 patients with UD, 33 patients with BD, and 34 healthy controls, is one of the first to directly compare UD and BD with respect to reward processing. A card-guessing paradigm was employed and brain activity associated with reward processing was investigated by means of fMRI. A 3 (group) × 2 (condition: reward4control, loss4control) ANOVA was conducted using the nucleus accumbens (NAcc) as ROI. Furthermore, a whole-brain approach was applied. A functional connectivity analysis was performed to characterize diagnosis-related alterations in the functional coupling between the NAcc and other brain areas. The ANOVA revealed higher activity for healthy controls (HCs) than for BD and UD in the NAcc during reward processing. Moreover, UD showed a higher functional connectivity between the NAcc and the VTA than HC. The patients groups could be differentiated in that BD showed a decreased activation, in the reward condition, of the NAcc, caudate nucleus, thalamus, putamen, insula, and prefrontal areas compared with UD. These results may help to refine the understanding of neural correlates of reward processing in both disorders, and to understand the neural underpinnings of anhedonia, a core symptom of depressive episodes.

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Section: Reward Processing In Ud and Bdmentioning

confidence: 98%

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Redlich

Dohm

Grotegerd

et al. 2015

Neuropsychopharmacol

139

View full text Add to dashboard Cite

show abstract

“…For example, studies have shown decreased connectivity between the anterior cingulate cortex (ACC) and amygdala in response to negative stimuli in unmedicated individuals with MDD. 13,14 Almeida and colleagues 15 reported reduced amygdala-left orbitomedial prefrontal functional connectivity during processing of happy and sad faces in medi cated patients with MDD. However, increased connectivity between frontal cortices, including the medial PFC and rostral ACC, and the amygdala when processing negative words has also been reported in depressed patients.…”

Section: Introductionmentioning

confidence: 99%

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

Kong

Chen

Tang

et al. 2013

J Psychiatry Neurosci

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“…Bipolar disorder patients exhibited elevated functional connectivity between MPFC and amygdala while viewing sad stimuli compared with healthy controls (Versace et al, 2010). Effective connectivity between MPFC and amygdala has been shown to differentiate bipolar disorder from major depression patients (Almeida et al, 2009). These results suggest that MPFClimbic connectivity may underlie the affective disturbance in bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia

Chai

Whitfield-Gabrieli

Shinn

et al. 2011

Neuropsychopharmacol

284

205

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Bipolar disorder and schizophrenia overlap in symptoms and may share some underlying neural substrates. The medial prefrontal cortex (MPFC) may have a crucial role in the psychophysiology of both these disorders. In this study, we examined the functional connectivity between MPFC and other brain regions in bipolar disorder and schizophrenia using resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI data were collected from 14 patients with bipolar disorder, 16 patients with schizophrenia, and 15 healthy control subjects. Functional connectivity maps from the MPFC were computed for each subject and compared across the three groups. The three groups showed distinctive patterns of functional connectivity between MPFC and anterior insula, and between MPFC and ventral lateral prefrontal cortex (VLPFC). The bipolar disorder group exhibited positive correlations between MPFC and insula, and between MPFC and VLPFC, whereas the control group exhibited anticorrelations between these regions. The schizophrenia group did not exhibit any resting-state correlation or anticorrelation between the MPFC and the VLPFC or insula. In contrast, neither patient group exhibited the significant anticorrelation between dorsal lateral prefrontal cortex (DLPFC) and MPFC that was exhibited by the control group. The decoupling of DLPFC with MPFC in bipolar disorder and schizophrenia is consistent with the impaired executive functioning seen in these disorders. Functional connectivity between MPFC and insula/VLPFC distinguished bipolar disorder from schizophrenia, and may reflect differences in the affective disturbances typical of each illness.

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Abnormal Amygdala-Prefrontal Effective Connectivity to Happy Faces Differentiates Bipolar from Major Depression

Cited by 279 publications

References 52 publications

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia

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