Ablative, Endovascular, and Biliary Interventions for Patients with Pancreatic Cancer

Abstract

Interventional radiologists have multiple points of involvement in the treatment and management of patients with pancreatic adenocarcinoma. There is increasing interest in cytoreductive treatment of the primary tumor as well as metastatic disease via arterial and ablative techniques. The focus of this article is on the current evidence for pancreatic irreversible electroporation. For patients undergoing curative surgery or terminal palliation, interventional radiology can manage complications and symptoms. In this article, therapeutic and palliative options in this group of patients including postoperative embolization, biliary drainage, and stent placement are reviewed.

YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration

“…Pancreatic cancer (PC) is the most malignant of digestive system neoplasms, with a 5‐year survival rate of less than 8% (Siegel, Miller, & Jemal, 2018). Although many efforts have been made towards clinical therapy for PC, the 5‐year survival rate of patients has not increased (Hevert, Howser, Gould, & Brown, 2019). Therefore, it is important to explore key biomarkers for the diagnosis of PC as well as to develop new therapeutic targets.…”

Interventional treatment of biliodigestive anastomosis leaks with a modified percutaneous transhepatic cholangiodrainage

“…Afterwards, treatment may require removal of the catheter over a wire followed by selective angiography for precise location and embolisation of the bleeding artery. [13][14][15] In the past, some authors have argued that any demonstration of bile leakage should be managed with prompt surgical repair. 16 However, new studies have demonstrated that 96% of biliary leakages treated solely with IR techniques resolved completely without residual stenosis and with a low complication rate and a procedure-related mortality of 0%.…”

“…In these cases, the diagnosis can be made with CT angiography to locate the vascular injury. Afterwards, treatment may require removal of the catheter over a wire followed by selective angiography for precise location and embolisation of the bleeding artery 13–15…”