Ablation therapy for the relief of meniere's disease

Hf, Schuknecht

doi:10.1288/00005537-195607000-00005

Cited by 202 publications

(92 citation statements)

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“…The idea of a topical application of medicine to the inner ear is not new. Local anaesthetics and aminoglycosides were applied decades ago to treat inner ear disorders (1,2,3). The present, most widely used form of intratympanic therapy is the injection of gentamicin into the middle ear in patients with Menière's disease (3,4,5,6,7,8).…”

Section: Introductionmentioning

confidence: 99%

Local inner-ear drug delivery and pharmacokinetics

Salt

Plontke

2005

Drug Discovery Today

159

123

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SummaryA number of drugs are in widespread clinical use for the treatment of inner ear disorders by applying them directly to the inner ear. Many new substances and drug delivery systems specific to the inner ear are under development, and in some cases are undergoing evaluations in animal experiments and in clinical studies. The pharmacokinetics of drugs in the inner ear, however, is not well defined and the field is plagued by technical problems in obtaining pure samples of the inner ear fluids for analysis. Nevertheless, a basic understanding of the mechanisms of drug dispersal in the inner ear has emerged that facilitates the design and interpretation of future pharmacokinetic studies.

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Section: Introductionmentioning

confidence: 99%

Local inner-ear drug delivery and pharmacokinetics

Salt

Plontke

2005

Drug Discovery Today

159

123

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“…The first publication about the use of intratympanic aminoglycosides (streptomycin) on Meniere's disease in 1950 was of Schuknecht [24]. The aim of this therapy is to cause chemical damage or perform the ablation maze sick, in order to stop the floating labyrinth malfunction, causing the symptoms of Meniere's disease, and create a lasting situation of hypofunction where the brain can compensate for.…”

Section: Intratympanic Gentamicin Injectionmentioning

confidence: 99%

Meniere’s Disease Treatment

Bogaz¹,

Silva²,

KnollRibeiro³

et al. 2017

Up to Date on Meniere's Disease

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“…In 1948, streptomycin was used to treat patients with unilateral Meniere's disease specifically on the basis of its vestibulotoxic effects (5). It was Harold Schuknecht who proposed the use of streptomycin as an alternative to surgical unilateral labyrinthine ablation (6). Francis Bauer, in 1969 and 1971 reported on the treatment of "Glue Ear" by using intratympanic urea (7).…”

Section: Historymentioning

confidence: 99%