Ablation of the great saphenous vein with nontumescent n-butyl cyanoacrylate versus endovenous laser therapy

Abstract

The NBCA-based vein sealing system is a fast and effective treatment option for the management of incompetent saphenous veins that does not involve tumescent anesthesia, compression stockings, paresthesia, burn marks, or pigmentation. Further large-scale studies with long-term outcomes are required to identify the optimal treatment modalities for patients with saphenous vein insufficiency.

A Randomised Clinical Trial Comparing N-Butyl Cyanoacrylate, Radiofrequency Ablation and Endovenous Laser Ablation for the Treatment of Superficial Venous Incompetence: Two Year Follow up Results

“…This corresponded with previous findings, 11,12 although one study reported a higher percentage of phlebitis after NBCA (20%). 21 The number of patients with ecchymosis in the RFA group was statistically significantly higher than in the other two groups in the study. Other authors also observed less ecchymosis after NBCA than after thermal ablation with EVLA or RFA.…”

“…Only two prospective studies have compared EVLA and NBCA. 12,21 No significant difference was found between the groups in these studies. The only randomised clinical trial to compare NBCA and RFA was the VeClose trial.…”

“…12 Korkmaz et al reported less pain in the NBCA group, but that this was not statistically significant. 21 Morrison et al reported similar peri-procedural pain in patients undergoing NBCA and RFA. 11 The mean time to return to work was 1.04 days in the NBCA group, 1.56 days in the RFA group, and 1.31 days in the EVLA group.…”

A Comparison of NBCA and RFA in Treating Varicose Veins in the Same Patient

“…Bozkurt and Yılmaz (11) subsequently compared NBCA with EVA and reported 12-month results. In 2017, Koramaz et al (10) published a study comparing NBCA and EVA, and in 2018 the VeClose study published its 24-month findings. Again in 2018, Yasim et al (8) and Eroglu and Yasim (9) .…”

“…Several studies involving NBCA have been published. Studies have also compared NBCA with other thermal ablation methods (8)(9)(10)(11) . However, no previous studies have compared the two techniques in the same patient.…”