Ablation of the Duodenal Mucosa as a Strategy for Glycemic Control in Type 2 Diabetes: Role of Nutrient Signaling or Simple Weight Loss

Garvey, W. Timothy

doi:10.2337/dc16-1611

Cited by 12 publications

(2 citation statements)

References 29 publications

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“…DMR, particularly when combined with hypocaloric intake, has long-lasting efficacy in controlling diabetes and reducing both intramyocellular and intrahepatocellular lipids, while favoring the mobilization of abdominal fat and improving glycemia. 56…”

Section: Duodenal Mucosal Resurfacingmentioning

confidence: 99%

Obesity and Current Treatment Approaches: A Comprehensive Review

Mathialagan,

Rondla,

Muralidharan

et al. 2024

J Transl Gastroenterol

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Obesity is a global health burden and is closely associated with severe chronic co-morbidities, which remain the leading causes of death. Significant progress has been made in the treatment of hypertension, diabetes, and hyperlipidemia over the last half-century. However, advancements in the management of obesity have been slow, with some medications exhibiting inadequate efficacy and dangerous side effects. Improved understanding of the gut-brain axis has inspired the pursuit of novel medications aiming to provide sustainable and safe weight loss. Current evidence-based practices for obesity management involve multi-modal approaches, including lifestyle modification, mechanical gastric restriction, modulation in the secretion of multiple gut hormones, alteration in the composition and secretion of bile acids, and alterations of the gut microbiome. Each physician is responsible for recognizing obesity as a disease and assisting patients in appropriate management based on strong evidence and a good safety profile, aligned with the patient's goals. Through this review, we aim to inform the readers of recent approaches for managing obesity and comparing their beneficial effects and efficacy on obesity and its long-term co-morbidities.

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Section: Duodenal Mucosal Resurfacingmentioning

confidence: 99%

Obesity and Current Treatment Approaches: A Comprehensive Review

Mathialagan,

Rondla,

Muralidharan

et al. 2024

J Transl Gastroenterol

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“…This procedure is primarily aimed at glycemic control. Though the precise mechanism has yet to be defined, it is hypothesized that DMR induces remodeling of the diseased duodenum with an overgrowth of enteroendocrine cells and dysregulated secretion of gastrointestinal hormones, which have been observed in diabetic patients [45]. The first human study of 39 patients with type II diabetes demonstrated a 1.2% reduction of hemoglobin A1c and a 2.5-kg weight reduction at 6 months.…”

Section: Duodenal Mucosal Resurfacingmentioning

confidence: 99%

Endoscopic Treatment for Obesity and Weight Management: State of the Art

Jaruvongvanich¹,

Storm²,

Dayyeh³

2020

Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy

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Obesity is a rising pandemic associated with numerous comorbidities and increased mortality. Although effective and durable, bariatric surgery is performed in less than 1% of eligible candidates. It has been underutilized due to its invasiveness, costs, and risk profile. At the other end of the obesity treatment spectrum, lifestyle intervention frequently fails to achieve effective and durable weight loss. Endoscopic bariatric therapies have emerged to bridge this treatment

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