Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences

Mikerov, Anatoly N.; Haque, Rizwanul; Gan, Xiaozhuang; Guo, Xiaoxuan; Phelps, David S.; Floros, Joanna

doi:10.1186/1465-9921-9-77

Cited by 67 publications

(167 citation statements)

References 78 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…Particulate matter originated from other sources, such as burning of fossil fuels and biomass, is also associated with increased incidence of pneumonia and increased symptoms and respiratory disease (Souza and Nascimento, 2016). Experimental and epidemiologic studies have demonstrated that the severity of pneumonia has positive associations with exposure of air pollutants (Harrod et al, 2003;Mikerov et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The impact of airborne particulate matter on pediatric hospital admissions for pneumonia among children in Jinan, China: A case-crossover study

Wang

Pang

et al. 2017

Journal of the Air & Waste Management Association

View full text Add to dashboard Cite

This study aims to examine the effect of short-term changes in the concentration of particulate matter of diameter ≤2.5 µm (PM 2.5 ) and ≤10 µm (PM 10 ) on pediatric hospital admissions for pneumonia in Jinan, China. It explores confoundings factors of weather, season, and chemical pollutants. Information on pediatric hospital admissions for pneumonia in 2014 was extracted from the database of Jinan Qilu Hospital. The relative risk of pediatric hospital admissions for pneumonia was assessed using a case-crossover approach, controlling weather variables, day of the week, and seasonality. The single-pollutant model demonstrated that increased risk of pediatric hospital admissions for pneumonia was significantly associated with elevated PM 2.5 concentrations the day before hospital admission and elevated PM 10 concentrations 2 days before hospital admission. An increment of 10 μg/m 3 in PM 2.5 and PM 10 was correlated with a 6% (95% CI 1.02--1.10) and 4% (95% CI 1.00-1.08) rise in number of admissions for pneumonia, respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

The impact of airborne particulate matter on pediatric hospital admissions for pneumonia among children in Jinan, China: A case-crossover study

Wang

Pang

et al. 2017

Journal of the Air & Waste Management Association

View full text Add to dashboard Cite

show abstract

“…Показано, что блокирование функции SP-A путем элимина-ции гена SP-A в генетически модифицированных SP-A (-/-) мы-шах или путем снижения функциональной активности белка SP-A вследствие его окисления озоном повышает чувствитель-ность мышей к экспериментальной пневмонии после ингаляции озона [34]. SP-A (-/-) мыши проявляли повышенную чувстви-тельность к ряду патогенных микроорганизмов, включая группу Streptococcus [35], P aeruginosa [36], H. influenza [27], P carinii [37,38], K. pneumonia [34].…”

Section: терапевтический архив 1 2015unclassified

“…SP-A (-/-) мыши проявляли повышенную чувстви-тельность к ряду патогенных микроорганизмов, включая группу Streptococcus [35], P aeruginosa [36], H. influenza [27], P carinii [37,38], K. pneumonia [34]. SP-D (-/-) мыши более восприимчивы к инфекциям дыхательных путей, вызываемым вирусом гриппа [17], респираторно-синцитиальным вирусом [28].…”

Section: терапевтический архив 1 2015unclassified

Significance of surfactant proteins in the diagnosis of therapeutic diseases

et al. 2015

View full text Add to dashboard Cite

“…inflammation, oxidative stress, phagocytosis, and other]. For example, human SP-A variants have been shown to differentially enhance the phagocytic activity of AM [3] and mice that lacked SP-A exhibited a lower phagocytic activity and survival [10].…”

mentioning

confidence: 99%

“…Moreover, the SP-A -/-rescue experiment [1] points to the possibility and feasibility of using SP-A as a therapeutic intervention in lung diseases influenced by innate immunity. Furthermore, based on animal studies [10] where small amounts of SP-A elicited significant differences in the AM proteome, it is possible that the SP-A amount needed may not be high, although, further experimentation will be needed to determine optimal amount and efficacy in the clinical setting.…”

mentioning

confidence: 99%

Human Surfactant Proteins (SP-) A1 and SP-A2: to Include or Not in Surfactant Replacement Therapy, and If Yes, Both or Which One?

Floros

Phelps²

2014

J Neonatal Biol

View full text Add to dashboard Cite

Based on a large number of animal studies, surfactant protein A plays important roles in lung innate immunity under basal conditions and in response to various insults such as infection and oxidative stress. SP-A interacts with the Alveolar Macrophage (AM), the sentinel cell of innate immunity, and regulates many of its functions. These include the ability of the AM to produce cytokines and to carry out phagocytosis of various pathogens. Moreover, the AM proteomic expression profile has been shown to be significantly affected by SP-A. In a study where SP-A -/-mice were treated (or rescued) in vivo with a single dose of human SP-A, the treatment nearly restored the AM proteomic expression to that of the wild type [1], supporting a role of SP-A on AM protein expression. Among the protein groups affected were actin-related/cytoskeletal proteins, which was the major group, proteins regulating inflammatory processes, and proteins related to Nrf2-mediated oxidative stress. Of interest, earlier studies have also indicated a role for SP-A in actin filament dynamics via its ability to enhance cell migration and AM chemotaxis [2], phagocytosis [3], other actin-dependent processes [4][5][6] and F-actin assembly [7]. The actin cytoskeleton is highly regulated and dynamic, with globular (G) and filamentous (F) actin, under the influence of many actin binding proteins, constantly changing by polymerization, depolymerization, branching, and remodeling, modulating inflammatory response and oxidative stress ( Figure 1). Figure, signaling via NF-kB [8] and Nrf2 [9] can both depend on cytoskeletal changes, indicating that SP-A-mediated modulation of the actin cytoskeleton could have significant effects on AM responses. Moreover, the SP-A -/-rescue experiment [1] points to the possibility and feasibility of using SP-A as a therapeutic intervention in lung diseases influenced by innate immunity. Furthermore, based on animal studies [10] where small amounts of SP-A elicited significant differences in the AM proteome, it is possible that the SP-A amount needed may not be high, although, further experimentation will be needed to determine optimal amount and efficacy in the clinical setting. As shown inHowever, humans, (unlike rodents) have two genes, SFTPA1 (SP-A1) and SFTPA2 (SP-A2) with several genetic variants identified for each SP-A1 and SP-A2 gene. These variants have been associated with many lung diseases including neonatal diseases, such as Respiratory Distress Syndrome (RDS) and Bronchopulmonary Dysplasia (BPD) [11]. The SP-A1 and SP-A2 gene products have been shown to differ in several functions related to innate immunity [12] and in surfactantrelated functions [13,14]. These differences have been reviewed previously [12] and include differences in their oligomerization status [13,15,16], their ability to form phospholipid monolayers [17], their ability to bind sugars [18], and their ability to enhance the phagocytic activity and cytokine production by the alveolar macrophages and macrophage-like cell lines, respectively [3,...

show abstract

Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences

Cited by 67 publications

References 78 publications

The impact of airborne particulate matter on pediatric hospital admissions for pneumonia among children in Jinan, China: A case-crossover study

The impact of airborne particulate matter on pediatric hospital admissions for pneumonia among children in Jinan, China: A case-crossover study

Significance of surfactant proteins in the diagnosis of therapeutic diseases

Human Surfactant Proteins (SP-) A1 and SP-A2: to Include or Not in Surfactant Replacement Therapy, and If Yes, Both or Which One?

Contact Info

Product

Resources

About