Ablation of Rotor Domains Effectively Modulates Dynamics of Human

Abstract

Rotor domains appropriately explain long-standing persistent atrial fibrillation physiology at its frequency content. Their ablation effectively modifies dynamics on restricted ablation.

Mechanisms and Drug Development in Atrial Fibrillation

“…1), how both theories reconcile with the observed spatiotemporal organization during AF and whether they may even be combined to explain AF remains a matter of continuing debate (Allessie and de Groot, 2014;Narayan and Jalife, 2014). But the transcendent concept here is that randomness has lost its prominence as an explanation for AF maintenance, the research community now favoring singular mechanisms, which, although highly complex, are nevertheless consistent with the hierarchical organization of the atria during AF and potentially able to produce the necessary physical or pharmacologic tools to terminate AF more effectively (Calvo et al, 2017).…”

Mapping of persistent atrial fibrillation: Learning to walk, step by step

“…[16][17][18] Results regarding the effect of PVI on the number of drivers also differ among studies, with results ranging from a 45% reduction in them, to no change, and also to an increase in the number of drivers. 17,18,20 The rate of AF termination after driver ablation likewise has differed between studies, with 2/13 patients in the study of Calvo et al and 12/19 patients in the study of Honarbakhsh. 18,20 Honarbakhsh et al presented a detailed analysis of their maps and observed termination in 83% of the stable drivers, which could be mapped before and after PVI.…”

“…17,18,20 The rate of AF termination after driver ablation likewise has differed between studies, with 2/13 patients in the study of Calvo et al and 12/19 patients in the study of Honarbakhsh. 18,20 Honarbakhsh et al presented a detailed analysis of their maps and observed termination in 83% of the stable drivers, which could be mapped before and after PVI.…”

“…The criteria used for detection of FA and RoA using CARTOFINDER and the mapping results differ among the limited publications currently available . Daoud et al identified repetitive activation patterns in 12 of 14 patients (mean=2.9 per patient), whereas Honarbakhsh identified 0.7 drivers in the LA in 11 of 20 patients.…”

“…In one study, all drivers were rotational, another study found 37% of drivers were FA, but Verma et al found a higher prevalence of FA than RoA . Results regarding the effect of PVI on the number of drivers also differ among studies, with results ranging from a 45% reduction in them, to no change, and also to an increase in the number of drivers . The rate of AF termination after driver ablation likewise has differed between studies, with 2/13 patients in the study of Calvo et al and 12/19 patients in the study of Honarbakhsh .…”