Ablation of CD226 on CD4+ T cells modulates asthma progress associated with altered IL-10 response and gut microbiota

Xie, Yang; Zhang, Yuan; Wang, Tingting; Liu, Yitian; Ma, Jingchang; Wu, Shihao; Duan, Chujun; Qiao, Wei; Cheng, Kun; Lu, Lianjun; Zhuang, Ran; Bian, Ka

doi:10.1016/j.intimp.2023.110051

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2024

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“…The concept of the gut-lung axis has significantly influenced the exploration of the association between asthma and the microbiome. It has been found that the gut-lung axis plays a substantial role in the initiation and progression of asthma [ 16 , 21 ]. Dysregulation of the gut microbiota not only modulates the immune response in the gastrointestinal tract, but also affects the immunity of distal organs, such as lung and airways, which may increase the risk of wheezing disorders caused by inflammation in children [ 22 ].…”

Section: Introductionmentioning

confidence: 99%