“…These in vivo experiments were based on previous results from the same group disclosing that the zone of thermal injury after Er:YAG laser ablation with increasing laser energy was much more pronounced in methacrylate than in rabbit long bones. 100 Thus in vital tissue, the thermal effects of laser treatment were much more complex and heat distribution had a much stronger influence on adjacent structures. A further influence of laser parameters on tissue damage was demonstrated by Walsh et al 101 In their study analyzing Er:YAG laser ablation of skin, cornea, aorta, and bone, Q-switched pulses caused less thermal damage, 101 could also show that pulse fluences greater than 20 J/cm 2 caused plasma formation by which ablation efficiency was decreased.…”