Ablagerungskrankheiten körpereigener Stoffwechselprodukte

Generalized Cutaneous Calcinosis and Mixed Connective Tissue Disease

“…In these disorders the plasma is oversaturated with calcium ions, which conditions the precipitation of calcium salts, mainly as calcium carbonate or phosphate, in many tissues. This concerns predominantly the internal organs, in rare cases also the skin [14,17,28], For generalized calcification of the skin alone, however, some other pathogenetic mechanism may exist. Although cutaneous calcinosis may rarely occur in association with hyper parathyroidism [11,24], as a rule this endocrine disorder is absent and serum levels and urine excretion of calcium and phosphate are normal.…”

PRIMARY SYSTEMIC AMYLOIDOSIS A Case Permitting Pathological and Biochemical Investigations

“…In this case, amyloid substances were deposited only in mesenchymal organs such as the skeletal and smooth muscles, but almost none were deposited in the parenchymal organs, The concept of amyloidosis in this present case may be the same as that of "systematisierte Haut-Muskel-Amyloidose" (GO'ITRON, 1932)10 or "systematisierte Paramyloidose" (LEVER, 1963 16). It is usually said that cases of typical primary systemic amyloidosis are characterized by disturbances in the cardiovascular system, smooth and skeletal muscles, lungs, skin, and gastrointestinal tracts without disturbances in the parenchymal organs; but many cases of primary systemic amyloidosis have displayed deposits of amyloid substances in the kidneys, spleen, and liver-", There are Acta Path.…”