Abiotrophia defectiva Infective Endocarditis: A Rare and Dangerous Cause of Endocarditis

Lancaster, Ian; Patel, Deep; Tamboli, Cyrus; Chun, Patricia; Sethi, Vikas; Namey, Joseph

doi:10.1155/2022/7050257

Cited by 4 publications

(9 citation statements)

References 19 publications

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“…In this case, the diagnosis of IE leading to severe aortic regurgitation was made by the utilization of POCUS. POCUS is a bedside imaging technique that provides real-time information about cardiac structures [3]. In this case, the presence of vegetation on the aortic valve was visualized using POCUS, which led to the early diagnosis of IE.…”

Section: Discussionmentioning

confidence: 97%

“…Blood cultures grew positive for bacilli (Abiotrophia defectiva). A. defectiva is a rare cause of IE which is mostly found in the oral cavity and the intestines and can be a cause of culture-negative endocarditis as it is very difficult to isolate and needs special media for culture [3]. We were advised by microbiology to treat him with Ceftriaxone and Gentamycin which resulted in significant improvement in his CRP.…”

Section: Laboratory Findingsmentioning

confidence: 99%

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The Role of Point-of-Care Ultrasound in the Emergency Department in the Diagnosis and Management of Infective Endocarditis

Malik,

Aziz,

Farooqi

et al. 2024

Cureus

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Section: Discussionmentioning

confidence: 97%

Section: Laboratory Findingsmentioning

confidence: 99%

The Role of Point-of-Care Ultrasound in the Emergency Department in the Diagnosis and Management of Infective Endocarditis

Malik,

Aziz,

Farooqi

et al. 2024

Cureus

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“…IE attributed to A. defectiva typically exhibits a protracted course of progression. Despite the organism’s susceptibility to antimicrobial agents, a substantial proportion, nearly 50%, of cases necessitate surgical intervention for effective management [ 11 ]. In this specific case, multiple embolic events transpired in the brain and spleen.…”

Section: Discussionmentioning

confidence: 99%

Abiotrophia defectiva Endocarditis: A Case Diagnosed Incidentally Due to Multi-organ Embolism

Suzuki,

Tsutsui,

Isa

et al. 2024

Cureus

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Abiotrophia defectiva , often referred to as nutritionally variant streptococci, is generally a benign part of human microflora, primarily found in the oral cavity, digestive tract, and genitourinary system. However, it can have a significant role in infectious endocarditis (IE). We discuss a case involving a 53-year-old male who displayed serious signs indicative of IE. The individual, who had a history of IgA nephropathy, underwent successful surgical and antibiotic intervention. Given the challenge in treating A. defectiva due to its high antibiotic resistance and the tendency for embolic events and treatment failure, a multidimensional approach involving surgical intervention and specific antibiotic therapy resulted in a successful outcome. This case underlines the need for early identification, immediate treatment, and additional research to understand better and manage A. defectiva endocarditis.

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“…1 Abiotrophia defectiva (A. defectiva) is a fastidious nutritionally variant microbe clinically implicated in osteomyelitis, brain abscess, and infective endocarditis. 2 This pathogen normally colonizes gastrointestinal tract and is a noted inhabitant of the oral flora. 2 A. defectiva is responsible for an estimated 17% mortality in cases complicated by infective endocarditis with multi system embolization.…”

Section: Introductionmentioning

confidence: 99%

Catheter related atrial thrombus caused by Abiotrophia defectiva: A case series and review of literature

et al. 2023

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Catheter related atrial thrombus (CRAT) is a devastating complication associated with tunneled hemodialysis catheter. Abiotrophia defectiva is a rare fastidious pathogen implicated predominantly in culture negative infective endocarditis. Here we report three cases of CRAT in maintenance hemodialysis patients with variable clinical presentation caused by Abiotrophia defectiva. Video assisted thoracoscopic retrieval of atrial thrombus is a novel technique which is scarcely reported in medical literature for surgical management of large atrial thrombus. Our cases were managed by timely administration of antibiotics and anticoagulants followed by surgical retrieval of atrial thrombus with removal of tunneled dialysis catheter. This case series illustrates the importance of prompt diagnosis, appropriate anticoagulation with antibiotics, and mini-invasive surgical removal of atrial thrombus for the management of CRAT.

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Abiotrophia defectiva Infective Endocarditis: A Rare and Dangerous Cause of Endocarditis

Cited by 4 publications

References 19 publications

The Role of Point-of-Care Ultrasound in the Emergency Department in the Diagnosis and Management of Infective Endocarditis

The Role of Point-of-Care Ultrasound in the Emergency Department in the Diagnosis and Management of Infective Endocarditis

Abiotrophia defectiva Endocarditis: A Case Diagnosed Incidentally Due to Multi-organ Embolism

Catheter related atrial thrombus caused by Abiotrophia defectiva: A case series and review of literature

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