Biochemical Pharmacology volume 78, issue 2, P105-114 2009 DOI: 10.1016/j.bcp.2009.02.009 View full text
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Lynn Verstrepen, Isabelle Carpentier, Kelly Verhelst, Rudi Beyaert

Abstract: AbstractABINs have been described as three different proteins (ABIN-1, ABIN-2, that bind the ubiquitin-editing nuclear factor-B (NF-B) inhibitor protein A20 and which show limited sequence homology. Overexpression of ABINs inhibits NF-B activation by tumor necrosis factor (TNF) and several other stimuli. Similar to A20, ABIN-1 and ABIN-3 expression is NF-B dependent, implicating a potential role for the A20/ABIN complex in the