Ability of ultrasound backscattering to predict mechanical properties of bovine trabecular bone

Hakulinen, Mikko; Töyräs, Juha; Saarakkala, Simo; Hirvonen, Jani; Kröger, Heikki; Jurvelin, Jukka S.

doi:10.1016/j.ultrasmedbio.2004.04.006

Cited by 71 publications

(55 citation statements)

References 41 publications

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“…The correlation coefficients reported in Tables IV and V are comparable to values reported in recent studies for BUB, AIB, and FSAB (Hakulinen et al, 2004;Hakulinen et al, 2005;Jenson et al, 2006;Hoffmeister et al, 2008;Padilla et al, 2008;Hoffmeister, 2011). The correlation coefficients in Tables IV and V were analyzed statistically using a Fisher R to z transformation and a two-tailed test with a 95% confidence interval.…”

Section: Utility Of Nmbd and Nsbd As Bone Assessment Parameterssupporting

confidence: 79%

“…Some studies have measured a parameter called broadband ultrasonic backscatter (BUB), which is the frequency averaged backscatter coefficient. BUB has been shown to be sensitive to the density, mechanical properties, and microstructure of cancellous bone (Chaffai et al, 2002;Hakulinen et al, 2004;Hakulinen et al, 2005;Hakulinen et al, 2006;Jenson et al, 2006;Padilla et al, 2008). BUB also may be sensitive to bone composition (Riekkinen et al, 2007a;Karjalainen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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A backscatter difference technique for ultrasonic bone assessment

Hoffmeister

Wilson

Gilbert

et al. 2012

The Journal of the Acoustical Society of America

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Ultrasonic backscatter techniques may offer a useful approach for detecting changes in cancellous bone caused by osteoporosis and other diseases. The goal of this study was to investigate the utility of a backscatter difference technique for ultrasonic bone assessment. Measurements were performed on 22 cube-shaped specimens of human cancellous bone using four broadband transducers with center frequencies 2.25, 5, 7.5, and 10 MHz. The backscatter difference spectrum D(f) was obtained by subtracting power spectra (in dB) from two different portions of the same backscatter signal. D(f) was found to be a monotonically increasing, quasi-linear function of frequency when averaged over multiple measurement sites on multiple specimens. The frequency slope of D(f) demonstrated weak to moderate correlations with specimen density (R ¼ 0.21-0.80). The frequency averaged mean of D(f) demonstrated moderate to good correlations with density (R ¼ 0.70-0.95). These results suggest that parameters based on the frequency averaged mean of the backscatter difference spectrum may be useful for bone assessment purposes.

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Section: Utility Of Nmbd and Nsbd As Bone Assessment Parameterssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

A backscatter difference technique for ultrasonic bone assessment

Hoffmeister

Wilson

Gilbert

et al. 2012

The Journal of the Acoustical Society of America

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“…However, this technique is unable to measure differences in the trabecular structure, which has been shown more related to the development of trabecular bone diseases [42]. Other in vivo techniques such as quantitative ultrasound (QUS) [28,78] and resonance frequency analyzers (RFA) [58,1] face the same problematic as DXA.…”

Section: Discussionmentioning

confidence: 99%

Techniques for Computing Fabric Tensors: A Review

Moreno

Borga

Smedby

2014

Mathematics and Visualization

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The aim of this chapter is to review different approaches that have been proposed to compute fabric tensors with emphasis on trabecular bone research. Fabric tensors aim at modeling through tensors both anisotropy and orientation of a material with respect to another one. Fabric tensors are widely used in fields such as trabecular bone research, mechanics of materials and geology. These tensors can be seen as semi-global measurements since they are computed in relatively large neighborhoods, which are assumed quasi-homogeneous. Many methods have been proposed to compute fabric tensors. We propose to classify fabric tensors into two categories: mechanics-based and morphology-based. The former computes fabric tensors from mechanical simulations, while the latter computes them by analyzing the morphology of the materials. In addition to pointing out advantages and drawbacks for each method, current trends and challenges in this field are also summarized.

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“…However, the number of signals per sample was limited compared to other studies because of the small acquisition sites studied and the convex format of diaphysis bone which made unfeasible a 2-dimention scanning. Comparison with other quantitative methods can be done to correlate density, composition and mechanical properties to ultrasonic parameters 8,26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…Quantitative ultrasound (QU) analysis has been extensively explored in the last decades as a means of biological tissue status discrimination [7][8][9] . Nevertheless, its capacity in the characterization of fibrocartilaginous tissue from pseudarthrosis lesions has not been well explored yet.…”

Section: Introductionmentioning

confidence: 99%

Characterization of pseudarthrosis with ultrasound backscattered signals in rats

Ferreira¹,

Matusin²,

Machado³

et al. 2010

Acta Cir. Bras.

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Purpose:To propose a novel model of pseudarthrosis in a small animal and to investigate the ability of backscatter parameters from ultrasound signals in differentiating normal bone from those ones with pseudarthorsis. Methods: Twelve Rattus norvegicus albinus free from pathogenic species (SPF) were randomly divided in two groups, with six animals each. In the Control group a surgical approach to the femur was made, followed by the synthesis of the muscle and skin layers. The Experimental group was submitted to an osteotomy of the femur and a vascularized flap of the fascia lata was interposed in the line of the fractured bone. Then the alignment and bone stabilization were accomplished, by using nylon stitch in U shape introduced in holes made in the proximal and distal fractured bone. Bone samples were scanned with ultrasound and signals were collected for each one to analyze the parameter Apparent Integrated Backscatter -AIB. Results: Radiological and anatomopathologic studies revealed the absence of bone consolidation with persistence of fiber-osteoid tissue. Values of the ultrasound parameter AIB from normal bones were statistically different from those with pseudarthrosis. Conclusion: The experimental model was suitable for pseudarthrosis development in rats and the ultrasound backscatter parameters were able to identify such a bone disease in vitro. Key words: Disease Models. Animal. Orthopedics. Ultrasonography. Rats. RESUMOObjetivo: Propor um novo modelo de pseudoartrose em animais de pequeno porte e investigar o potencial de parâmetros de retroespalhamento de ultrassônico em diferenciar osso normal e com pseudoartrose. Métodos: Doze Rattus norvegicus albinus (SPF) foram distribuídos aleatoriamente em dois grupos, tendo cada grupo seis animais. No grupo Controle realizou-se uma abordagem cirúrgica ao fêmur, seguida da síntese por planos do músculo e da pele. O grupo Experimental foi submetido à osteotomia do fêmur aduzida da confecção de um retalho pediculado de fascia lata para interposição entre os segmentos resultantes da fratura induzida cirurgicamente. Prosseguiu-se com o alinhamento e estabilização óssea, mediante a confecção de um nó com fio de náilon em formato de U, introduzido em orifícios efetuados nas extremidades proximal e distal à fratura. As amostras ósseas foram irradiadas pelo ultrassom e sinais foram coletados para cada uma no intuito de analisar o parâmetro Retroespalhamento Integrado Aparente -AIB. Resultados: Estudos radiológicos e anatomopatológicos evidenciaram a ausência de consolidação óssea com persistência de tecido fibro-osteóide. Os valores de AIB para ossos normais foram estatisticamente diferentes em relação aos ossos com pseudoartrose. Conclusão: O modelo experimental apresentou-se adequado para a formação de pseudoartrose em ratos e o parâmetro de retroespalhamento de ultrassom foi capaz de detectar tal doença óssea, in vitro. Descritores: Modelos Animais de Doenças. Ortopedia. Ultrassonografia. Ratos

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Ability of ultrasound backscattering to predict mechanical properties of bovine trabecular bone

Cited by 71 publications

References 41 publications

A backscatter difference technique for ultrasonic bone assessment

A backscatter difference technique for ultrasonic bone assessment

Techniques for Computing Fabric Tensors: A Review

Characterization of pseudarthrosis with ultrasound backscattered signals in rats

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