Ability of the Heidelberg Retina Tomograph to Detect Early Glaucomatous Visual Field Loss

Mikelberg, Frederick S.; Parfitt, Craig M; Swindale, Nicholas V.; Graham, Stuart; Drance, Stephen M.; Gosine, Raymond G.

doi:10.1097/00061198-199508000-00005

Cited by 271 publications

(191 citation statements)

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“…Several cross-sectional studies have investigated their diagnostic ability, often reporting good results. 16,19,21,24,25,27,59 Other longitudinal studies have reported a significant predictability for the development of POAG in the case of MRA, 60,61 but not for GPS. 60 In the OHTS both FSM and MRA were significantly predictive for the development of POAG at 5 years, 35 whereas MRA and GPS were significantly predictive for the development of POAG at 12 years.…”

Section: Discussionmentioning

confidence: 97%

“…The multidiscriminant functions FSM 16 and RB, 25 as well as the classification systems such as the MRA 21 and the GPS, 24 have been developed in order to achieve an accurate and simple clinical identification of abnormal (glaucomatous) discs. Several cross-sectional studies have investigated their diagnostic ability, often reporting good results.…”

Section: Discussionmentioning

confidence: 99%

“…The FSM uses a formula that takes into account rim volume, cup shape measure, and height variation contour, adjusting for age. 16 The RB uses the same parameters as the FSM, but weights them differently. 25 Both discriminant analyses classify the image as being normal or outside normal limits.…”

Section: The Egps Was a Multicenter Randomized Double-mentioning

confidence: 99%

“…From the introduction of the first dedicated HRT confocal scanning laser ophthalmoscope (CSLO) in 1989 for disc imaging and topography, 15 the overall agreement based on the results of several studies is that HRT may identify early signs of structural glaucomatous damage. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] The HRT Ancillary Study of the OHTS has confirmed these observations, suggesting that the clinical use of HRT in OHT patients may predict the development of POAG. [34][35][36] This report describes the HRT predictive parameters for development of OAG among the OHT patients enrolled in the EGPS.…”

mentioning

confidence: 98%

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Predictive Value of Heidelberg Retina Tomograph Parameters for the Development of Glaucoma in the European Glaucoma Prevention Study

Miglior

Zeyen

Torri

et al. 2015

American Journal of Ophthalmology

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PURPOSE: To determine whether baseline Heidelberg Retina Tomograph (HRT) measurements of the optic disc are associated with the development of open-angle glaucoma (OAG) in individuals with ocular hypertension in the European Glaucoma Prevention Study (EGPS).DESIGN: Retrospective analysis of a prospective, randomized, multicenter, double-masked, controlled clinical trial.METHODS: There were 489 participants in the HRT Ancillary Study to the EGPS. Each baseline HRT parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of OAG. Proportional hazards models were used to identify HRT variables that predicted which participants in the EGPS had developed OAG. Development of OAG was based on visual field and/or optic disc changes.RESULTS: At a median follow-up time of about 5 years, 61 participants developed OAG. In multivariate analyses, adjusting for randomization arm, age, baseline IOP, central corneal thickness, pattern standard deviation, and HRT disc area, the following HRT parameters were associated with the development of OAG: the ''outside normal limits'' classification of the Frederick Mikelberg (FSM) discriminant function (hazard ratio [HR] 2.51, 95% confidence interval [CI]: 1.45-4.35), larger mean cup depth (HR 1.64, 95% CI: 1.21-2.23), cup-to-disc area ratio (HR 1.43, 95% CI: 1.14-1.80), linear cup-to-disc ratio (HR 1.43, 95% CI: 1.13-1.80), cup area (HR 1.33, 95% CI: 1.08-1.64), smaller rim area (HR 1.33, 95% CI: 1.07-1.64), larger cup volume (HR 1.30, 95% CI: 1.05-1.61), smaller rim volume (HR 1.25, 95% CI: 1.01-1.54), larger maximum cup depth (HR 1.18, 95% CI: 1.01-1.36), and cup shape measure (HR 1.18, 95% CI: 1.01-1.36).CONCLUSIONS: Several baseline HRT parameters, alone or in combination with baseline clinical and demographic factors, were significantly associated with the development of OAG among the EGPS participants. (Am J Ophthalmol 2015;159:265-276. Ó 2015 by Elsevier Inc. All rights reserved.)

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: The Egps Was a Multicenter Randomized Double-mentioning

confidence: 99%

mentioning

confidence: 98%

See 2 more Smart Citations

Predictive Value of Heidelberg Retina Tomograph Parameters for the Development of Glaucoma in the European Glaucoma Prevention Study

Miglior

Zeyen

Torri

et al. 2015

American Journal of Ophthalmology

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“…1,2 The observer can use different mathematical approaches to distinguish normal ONHs from abnormal ones. [3][4][5][6][7][8] The Moordfield Regression Analysis or the linear discriminant function analysis are able to detect glaucomatous ONHs with a sensitivity and specificity around 80-90%. [3][4][5][6][7][8] However, there are two weak points in the HRT methodology: the reference plane and the contourline.…”

Section: Introductionmentioning

confidence: 99%

Detection of glaucomatous optic nerve head by using Heidelberg topographic maps

Iester

Zanini

Vittone

et al. 2006

Eye

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Detection of Glaucoma With Scanning Laser Polarimetry

Weinreb

Zangwill²,

Berry³

et al. 1998

Arch Ophthalmol

205

155

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To determine which retinal nerve fiber layer (RNFL) measures obtained with scanning laser polarimetry are most useful in detecting early to moderate glaucomatous visual field loss.Subjects and Methods: One eye from 84 healthy individuals and 83 patients with early to moderate glaucomatous visual field loss (167 eyes) was assessed with a scanning laser polarimeter (Laser Diagnostic Technologies, San Diego, Calif). Three separate scans were obtained, and a baseline scan was created and used in the analyses. Integrated software (program GDx, version 1.0.02; Laser Diagnostic Technologies) was evaluated by assessing its sensitivity and specificity for detecting early and moderate glaucomatous visual field loss. Fisher linear discriminant functions also were developed in this population to assess sensitivity and specificity and were compared with the GDx analyses.Results: There were statistically significant differences between the healthy and glaucomatous eyes for 14 of the 15 RNFL measures (P = .001). However, considerable overlap in measurements between groups was found. With the GDx number, the area under the receiver operator characteristic (ROC) curve was 0.78, and the sensitivity and specificity were 82% and 62%, respectively. Applying the best discriminant function using 3 variables (average thickness, ellipse modulation, and average ellipse thickness) to our study population resulted in an area under the ROC curve of 0.89 and a sensitivity and specificity of 74% and 92%, respectively.Conclusions: A combination of RNFL measures obtained using the scanning laser polarimeter improved the ability to differentiate between healthy eyes and eyes with early and moderate glaucomatous visual field loss. Analyses using GDx software did not differentiate between healthy and glaucomatous eyes as well as the discriminant analysis function did.

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Ability of the Heidelberg Retina Tomograph to Detect Early Glaucomatous Visual Field Loss

Cited by 271 publications

References 0 publications

Predictive Value of Heidelberg Retina Tomograph Parameters for the Development of Glaucoma in the European Glaucoma Prevention Study

Predictive Value of Heidelberg Retina Tomograph Parameters for the Development of Glaucoma in the European Glaucoma Prevention Study

Detection of glaucomatous optic nerve head by using Heidelberg topographic maps

Detection of Glaucoma With Scanning Laser Polarimetry

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