Ability of Swept-source OCT and OCT-angiography to detect neuroretinal and vasculature changes in patients with Parkinson disease and essential tremor

Satué, María; Castro, Luísa; Viladés, Elisa; Ciordía, Beatriz Cordón; Errea, José M.; Pueyo, Ana; Chueca, Eva Pilar; García‐Martín, Elena

doi:10.1038/s41433-022-02112-4

Cited by 14 publications

(16 citation statements)

References 29 publications

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“…In contrast, Rascuna et al reported that PD patients showed no signi cant differences in OCTA parameters in DRCP or SRCP compared with healthy controls 10 . When the OCTA parameters in PD, essential tremor, and healthy controls were compared, differences were not observed among the three groups 11 . These inconsistent results indicate that a range of factors can affect the OCTA ndings.…”

Section: Discussionmentioning

confidence: 91%

“…PD patients were shown to have a lower macular vessel density than healthy controls, indicating that OCTA parameters can be a potential diagnostic biomarker 8,9 . In contrast, others reported no signi cant differences in the OCTA parameters of patients with PD compared with healthy controls or patients with essential tremors, and scienti c evidence explaining the inconsistent results and pathophysiology of microvascular alteration in PD is lacking [10][11][12] . In the present study, we hypothesised that OH in PD is potentially associated with microvasculature damage and OCTA would be useful to detect microvasculature damage in PD patients.…”

Section: Introductionmentioning

confidence: 97%

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Retinal microvasculature damage associated with orthostatic hypotension in Parkinson’s disease

Youn

Ahn

Kang

et al. 2022

Preprint

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Orthostatic hypotension (OH) is a common non-motor symptom in Parkinson’s disease (PD). OH can cause cerebral and retinal hypoperfusion and is associated with microvascular damage in PD. Optical coherence tomography angiography (OCTA) is a non-invasive technology that can be used to visualise the retinal microvasculature and detect the microvascular damage in PD. In the present study, 51 PD patients (OH+, n = 19; OH−, n = 32) and 40 healthy controls were evaluated. The Unified Parkinson’s Disease Rating Scale (UPDRS) III, Hoehn and Yahr (H&Y) scale, Montreal Cognitive Assessment (MoCA), levodopa equivalent daily dose (LEDD) and vascular risk factors including hypertension, diabetes, and dyslipidaemia, were investigated. The PD patients underwent a head-up tilt (HUT) test. The PD patients had a lower superficial retinal capillary plexus (SRCP) and deep retinal capillary plexus (DRCP) vessel densities in the central region than controls. The PDOH + group had lower vessel density in the SRCP central region compared with the control group, and lower vessel density in the DRCP central region than the PDOH − and control groups. The changes in diastolic blood pressure (DBP) during the HUT test in PD patients showed a negative correlation with the vessel density in the DRCP central region. The results showed the presence of OH was a critical factor associated with the microvasculature damage in PD. The findings indicate that OCTA can be a useful and non-invasive tool for detecting microvasculature damage in PD patients.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 97%

Retinal microvasculature damage associated with orthostatic hypotension in Parkinson’s disease

Youn

Ahn

Kang

et al. 2022

Preprint

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“…However, when using angiography mediated by OCT technology they did not nd any differences in vasculature dynamics and structure between groups. [ (13,17,33)] This could be because the tissue structures observed by OCT in the choroid differ from the analysis of purely vascular structures and, mainly, of ux density in the deep and super cial choroidal plexus. Conversely, Eraslan et al (2016) and Moschos et al (2017) found a decrease in choroidal thickness in PD patients' eyes in results obtained using SD-OCT outputs.…”

Section: Resultsmentioning

confidence: 99%

“…Before their inclusion in the study, all subjects were evaluated by means of clinical interviews and a complete ophthalmological examination to rule out the following systemic and ophthalmological alterations that could in uence the OCT measurements (as seen in other studies): high refractive defects, opacity in ocular media, prior intraocular surgery, high intraocular pressure (IOP), or glaucoma, optic neuropathies, diabetes mellitus, or any cause of visual loss not attributable to the diseases of interest (PD or MS). [ (13,17,18)] Retinal OCT images were recorded by an experienced technician using swept-source (SS) OCT technology and the HD-line examination protocol with the Tru-Track eye-tracking technology available with the Deep Range Imaging (DRI) Triton (Topcon Corporation, Tokyo, Japan) SS-OCT device. All these clinical procedures were developed according towere performed in accordance with guidelines and regulations.…”

Section: Clinical Proceduresmentioning

confidence: 99%

Detecting Structural changes in the retina of neurodegenerative patients through OCT supervised segmentation

Otı́n

Ávila

Mallen

et al. 2023

Preprint

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Background To evaluate alterations of the choroid in neurodegenerative disease patients versus healthy controls using a custom supervised algorithm based on superpixel segmentation. Methods The prospective study protocol and procedures were approved by the Aragon Research Ethics Committee (CEICA) according to Declaration of Helsinki. Informed consent was obtained from all participants included in the study. Swept-source optical coherence tomography (OCT) B-scan images obtained using a Triton (Topcon, Japan) device were compiled. Images were included from three cohorts: multiple sclerosis (MS) patients and Parkinson disease (PD) patients diagnosed by a neurologist, and healthy subjects. 104 OCT B-scan images were processed using a custom supervised superpixel segmentation (SpS) algorithm to detect boundary limits in the choroidal layer. The algorithm groups pixels with similar structural image properties to generate clusters with similar meaningful properties. SpS automatically selects and groups the superpixels in a segmented choroidal area, computing the choroidal optical image density (COID), the total choroidal area (CA), and choroid density (CD). Results CA and CD were significantly reduced in the two neurodegenerative diseases (higher in PD than in MS) versus healthy subjects (p < 0.001). COID increased significantly in PD patients versus MS patients and in MS patients versus healthy controls (p < 0.001). Conclusions The SpS algorithm detects choroidal tissue and significant changes in choroidal images proprieties in MS and PD patients versus healthy controls. Application of the SpS algorithm to OCT images potentially acts as a non-invasive biomarker for early diagnosis of MS and PD.

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“…Methodological differences limit the comparison of findings across the studies. [7][8][9][10] Moreover, to date, no evidence has been provided regarding retinal differences between ET and early PD or among PD phenotypes.…”

mentioning

confidence: 99%

Retinal Thickness in Essential Tremor and Early Parkinson Disease: Exploring Diagnostic Insights

Terravecchia¹,

Mostile²,

Chisari³

et al. 2023

Journal of Neuro-Ophthalmology

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Background: Essential tremor (ET) represents a heterogeneous condition which may overlap with Parkinson disease (PD) even at early stages, by sharing some subtle clinical aspects. Longstanding ET demonstrated also higher risk of developing PD, especially with a Tremor-dominant (TD-PD) phenotype. Therefore, differential diagnosis between ET and early PD could be quite challenging. Optical coherence tomography (OCT) has been recognized as a reliable tool to assess the retina as a proxy of neurodegeneration. We aimed to explore the possible role of retinal assessment in differential diagnosis between ET and early PD. Methods: Macular layers and peripapillary retinal nerve fiber layer (RNFL) thickness among ET, early PD, and healthy controls (HCs) were assessed using OCT. Results: Forty-two eyes from 23 ET, 41 eyes from 21 early PD, and 33 eyes from 17 HCs were analyzed. Macular RNFL, ganglion cell layer, inner plexiform layer, and inner nuclear layer were thinner in PD as compared with ET and even more in HCs. Differences between ET and PD were more evident when considering the TD-PD subgroup, especially for RNFL. Among ET patients, thickness of the inner macular layers showed negative linear relationship with both age at onset and disease duration. Peripapillary temporal quadrant thinning was found in ET compared with HCs. Conclusions: Macular inner retina was thinner in patients with ET and early PD compared with HCs. These findings suggest that the retinal assessment may have a utility in the differential diagnosis between ET and PD.

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Ability of Swept-source OCT and OCT-angiography to detect neuroretinal and vasculature changes in patients with Parkinson disease and essential tremor

Cited by 14 publications

References 29 publications

Retinal microvasculature damage associated with orthostatic hypotension in Parkinson’s disease

Retinal microvasculature damage associated with orthostatic hypotension in Parkinson’s disease

Detecting Structural changes in the retina of neurodegenerative patients through OCT supervised segmentation

Retinal Thickness in Essential Tremor and Early Parkinson Disease: Exploring Diagnostic Insights

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