Ability of antiserum to myotoxin a from prairie rattlesnake (Crotalus viridis viridis) venom to neutralize local myotoxicity and lethal effects of myotoxin a and homologous crude venom

Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle

“…A total of 5 slides were counted from each mouse. Myonecrosis was expressed as myonecrosis index (number of necrotic cells compared to total number of cells) (OwNBY et al, 1983).…”

Biochemical characterization of two hemorrhagic proteases from the venom of Lachesis muta (bushmaster)

“…The Crotalidae toxins usually cause pronounced local tissue damage. Extensive studies have been made of the hemorrhagic, myotoxic, and other components from the venoms of North American pit vipers (24)(25)(26)(27)(28). It is thus of interest to find how the hemorrhagic toxins isolated from Lachesis differ from other pit viper venoms.…”

Regional vs Systemic Antivenom Administration in the Treatment of Snake Venom Poisoning in a Rabbit Model: A Pilot Study☆

“…The literature on this point is somewhat mixed. Some authors have found no protective effect from antivenom on necrosis in animal models, 6 –9 whereas others have suggested some degree of benefit in this regard. 10 –12…”

“…The literature on this point is somewhat mixed. Some authors have found no protective effect from antivenom on necrosis in animal models, [6][7][8][9] whereas others have suggested some degree of benefit in this regard. [10][11][12] Bite site tissue necrosis is thought to be largely due to local hemorrhage and cell membrane disruption 13,14 venom effects that occur quickly and are poorly responsive to systemic antivenom administration.…”