Abietanoid acid from Lepechinia caulescens

Spasmolytic effect of constituents from Lepechinia caulescens on rat uterus

“…Chemical investigations of the aerial parts of Lepechinia caulescens led to the characterization of the known compounds: salvigenin, cirsimaritin, stigmasterol, betulinic, oleanolic, ursolic, and maslinic acids (Delgado et al, 1992). Furthermore, a variety of abietane diterpenes have also been described, among which dehydroabietic acid, 7␣-hydroxydehydroabietic acid and 7␤-hydroxy-9␣,13␣-endoperoxiabieta-8(14)-en-18-oic acid are components of the acetone extracts (Delgado et al, 1992(Delgado et al, , 1994.…”

“…Furthermore, a variety of abietane diterpenes have also been described, among which dehydroabietic acid, 7␣-hydroxydehydroabietic acid and 7␤-hydroxy-9␣,13␣-endoperoxiabieta-8(14)-en-18-oic acid are components of the acetone extracts (Delgado et al, 1992(Delgado et al, , 1994.…”

Spasmolytic action of Lepechinia caulescens is through calcium channel blockade and NO release

“…In previous investigations, a phytochemical analysis of Lepechinia caulescens had led the isolation of terpenoids and sterols (Delgado et al, 1992(Delgado et al, , 1994, and pharmacological evaluations showed that this plant has antidiabetic (Román-Ramos et al, 2001) and spasmolytic (Rodríguez-López et al, 2003) activities. Recently, we also showed that Lepechinia caulescens has vasorelaxant properties due to NO release by activation of eNOS (Aguirre-Crespo et al, 2005).…”

A Diterpene Endoperoxide from Microtoena insuavis (Hance) Prain ex Dunn

“…The hydroxyl group at δ 4.97 could be assigned as 7-OH from the HMBC correlations of 7-OH (δ 4.97) with C-6, C-7, and C-8 ( Figure 1). The above evidence revealed a close structural similarity to 7β-hydroxy-abieta-8(14)-en-18-oic acid 9α, 13α-endoperoxide (compound 12; Delgado et al 1992), with the exception of a hydromethyl group in compound 1 and a carboxyl group in compound 12. This hydroxymethyl group ( …”