Abietane Diterpenoids from <i>Salvia pachyphylla</i> and <i>S. clevelandii</i> with Cytotoxic Activity against Human Cancer Cell Lines

Guerrero, Iván Córdova; Andrés, Lucía S.; León, Leticia G.; Machín, Rubén P.; Padrón, José M.; Luis, Javier G.; Delgadillo, José

doi:10.1021/np060279i

Cited by 61 publications

(42 citation statements)

References 22 publications

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“…To the opposite, concentrations of rosmarinic acid ranging from 6.25 to 50 lg/mL (139 lM) showed proliferative effects rather than cytotoxic activity (Yesil-Celiktas et al 2010). Carnosol exhibited growth inhibition 50 % (GI 50 ) values ranging from 3.6 to 26 lM in five tumor cells (Guerrero et al 2006). Also, Visanji et al (2006) reported IC50 values of 23 lM of carnosol for Caco-2 cells, a value close to the observed (34 lM) in prostate cancer cells after 72 h of treatment (Johnson 2011).…”

Section: Discussionmentioning

confidence: 99%

Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

et al. 2012

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In this work, the effect of rosemary extracts rich on polyphenols obtained using pressurized fluids was investigated on the gene expression of human SW480 and HT29 colon cancer cells. The application of transcriptomic profiling and functional enrichment analysis was done via two computational approaches, Ingenuity Pathway Analysis and Gene Set Enrichment Analysis. These two approaches were used for functional enrichment analysis as a previous step for a reliable interpretation of the data obtained from microarray analysis. Reverse transcription quantitative-PCR was used to confirm relative changes in mRNA levels of selected genes from microarrays. The selection of genes was based on their expression change, adjusted p value, and known biological function. According to genome-wide transcriptomics analysis, rosemary polyphenols altered the expression of *4 % of the genes covered by the Affymetrix Human Gene 1.0ST chip in both colon cancer cells. However, only *18 % of the differentially expressed genes were common to both cell lines, indicating markedly different expression profiles in response to the treatment. Differences in induction of G2/ M arrest observed by rosemary polyphenols in the two colon adenocarcinoma cell lines suggest that the extract may be differentially effective against tumors with specific mutational pattern. From our results, it is also concluded that rosemary polyphenols induced a low degree of apoptosis indicating that other multiple signaling pathways may contribute to colon cancer cell death.

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Section: Discussionmentioning

confidence: 99%

Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

et al. 2012

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“…Several diterpenes including carnosol (42), rosmanol (46), 20-deoxocarnosol (43), carnosic acid (51), isorosmanol (44), 7-methoxyrosmanol (47), 5,6-didehydro-O-methylsugiol (55), 8b-hydroxy-9(11),13-abietadien-12-one (57), 11,12-dioxoabieta-8,13-diene (58), 11,12-dihydroxy-20-norabieta-5(10),8,11,13-tetraen-1-one (59) and pachyphyllone (60) isolated from S. pachyphylla as well as rosmadial (61), 16-hydroxycarnosol (45), abieta-8,11,13-triene (52), taxodone (62), 42, 46, and 51 isolated from S. clevelandii have shown efficacy against different human cancer cell lines (Table 1) (Guerrero et al 2006). Carnosol (IC 50 : 3.6-26.0 lM), 16-hydroxycarnosol (IC 50 : 3.6-35.0 lM) and 20-deoxocarnosol (IC 50 : 5.4-32.0 lM) were the most active components, however, no comparison was made with a known anticancer agent (Guerrero et al 2006).…”

Section: Biological Activitymentioning

confidence: 99%

“…Carnosol (IC 50 : 3.6-26.0 lM), 16-hydroxycarnosol (IC 50 : 3.6-35.0 lM) and 20-deoxocarnosol (IC 50 : 5.4-32.0 lM) were the most active components, however, no comparison was made with a known anticancer agent (Guerrero et al 2006).…”

Section: Biological Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea (clary sage) have been used as medicinal plants in the folk medicine of several countries. In this review, we discuss the reports that have examined Salvia species with the aim of isolation of pure compounds with different biological activities. The phytochemical analyses of various sage plants have reported 10 monoterpenoids (1-10), 1 sesquiterpenoid (11), 8 labdane (13-20), 15 ent-kaurane (21-35), 82 abietane, rearranged abietane and tanshinone (36-117), 3 icetexane (118-120), 43 clerodane (121-163), and 3 pimarane (164-166) diterpenoids with cytotoxic and antimicrobial, antiprotozoal, antioxidant, phytotoxic and insecticide effects. The other heavier terpenoids, including 3 sesterterpenes (167-169), 10 triterpenoids and b-sitosterol (170-180) have been introduced as minor bioactive compounds in the sage plants. Sahandinone (107), 6,7-dehydroroyleanone, 7-a-acetoxyroyleanone (40), and tanshinone like diterpenoids have been isolated from the roots' extracts of different Salvia species. On the other hand, several radical scavenger phenolic compounds like simple phenolics and caffeic acid derivatives (181-201) including rosmarinic acid, flavonoids (202-217) as well as phenolic diterpenoids, such as carnosol and carnosic acid have been isolated from the aerial parts of these plants. One pyrrole (218) and 3 antimicrobial oxylipins (219-221) are among the other less detected constituents in the members of Salvias. Furthermore, sages also synthesize antifungal, antileishmanial and antimalarial phytochemicals in their roots and shoots, which are reviewed in this paper. We also examine the allelopathic phenomena and the ecologically important phytochemicals identified in different parts of the sage plants. Finally, antifeedant and insecticide phenomena, which are due to the presence of volatile monoterpenes and clerodane diterpenes in these plants, are discussed. Considering the presence of diverse biologically active phytochemicals in the sage plants, they can be suggested as suitable candidates for the formulation of valuable natural medicines.

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“…These naturally occurring compounds display a vast array of biological activities including cytotoxic and antiproliferative activities against human tumor cells (Wang et al, 2007;Fronza et al, 2012). One of these compounds is taxodone which has been isolated from the aerial parts of Salvia clevelandii (Guerrero et al, 2006) and Salvia phlomoides (HuesoRodríguez et al, 1983) and displays cytotoxic effects and it is a relatively potent apoptotic inducer. Recently, we described how diterpenoids containing an abietane skeleton are strongly cytotoxic against human leukemia cells (Burmistrova et al, 2013).…”

Section: Parvifloron D Inhibits Cell Viability Of Human Tumor Cell Linesmentioning

confidence: 99%

The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells

et al. 2015

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Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines

Cited by 61 publications

References 22 publications

Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

Bioactive phytochemicals from shoots and roots of Salvia species

The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells

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