Aberration correction in abdominal histotripsy

Yeats, Ellen; Hall, Timothy L.

doi:10.1080/02656736.2023.2266594

Cited by 4 publications

(2 citation statements)

References 164 publications

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“…Differences in the speed of sound between tissues and the water bath may cause phase shifts, which can result in a change in cavitation bubble cloud location. 29 The purpose of this sub‐investigation was to assess whether the materials used for the phantom would cause notable changes (aberration) in the bubble cloud location due to the differences in the speed of sound compared to water. Large aberrations would limit the utility of the phantom to predict targeting accuracy since the results would not be representative of the targeting accuracy observed in vivo.…”

Section: Methodsmentioning

confidence: 99%

A target containing phantom for accuracy assessment of cone‐beam CT‐guided histotripsy

Kutlu,

Minesinger,

Laeseke

et al. 2024

J Applied Clin Med Phys

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PurposeHistotripsy is a nonionizing, noninvasive, and nonthermal focal tumor therapy. Cone‐beam computed tomography (CBCT) guidance was developed for targeting tumors not visible on ultrasound. This approach assumes cavitation is formed at the geometrical focal point of the therapy transducer. In practice, the exact location might vary slightly between transducers. In this study, we present a phantom with an embedded target to evaluate CBCT‐guided histotripsy accuracy and assess the completeness of treatments.MethodsSpherical (2.8 cm) targets with alternating layers of agar and radiopaque barium were embedded in larger phantoms with similar layers. The layer geometry was designed so that targets were visible on pre‐treatment CBCT scans. The actual histotripsy treatment zone was visualized via the mixing of adjacent barium and agar layers in post‐treatment CBCT images. CBCT‐guided histotripsy treatments of the targets were performed in six phantoms. Offsets between planned and actual treatment zones were measured and used for calibration refinement. To measure targeting accuracy after calibration refinement, six additional phantoms were treated. In a separate investigation, two groups (N = 3) of phantoms were treated to assess visualization of incomplete treatments (“undertreatment” group: 2 cm treatment within 2.8 cm tumor, “mistarget” group: 2.8 cm treatment intentionally shifted laterally). Treatment zones were segmented (3D Slicer 5.0.3), and the centroid distance between the prescribed target and actual treatment zones was quantified.ResultsIn the calibration refinement group, a 2 mm offset in the direction of ultrasound propagation (Z) was measured. After calibration refinement, the centroid‐to‐centroid distance between prescribed and actual treatment volumes was 0.5 ± 0.2 mm. Average difference between the prescribed and measured treatment sizes in the incomplete treatment groups was 0.5 ± 0.7 mm. In the mistarget group, the distance between prescribed and measured shifts was 0.2 ± 0.1 mm.ConclusionThe proposed prototype phantom allowed for accurate measurement of treatment size and location, and the CBCT visible target provided a simple way to detect misalignments for preliminary quality assurance of CBCT‐guided histotripsy.

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Section: Methodsmentioning

confidence: 99%

A target containing phantom for accuracy assessment of cone‐beam CT‐guided histotripsy

Kutlu,

Minesinger,

Laeseke

et al. 2024

J Applied Clin Med Phys

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“…9 While CBCT targeting has been shown to be feasible and accurate, 9 a framework that allows for treatment planning in advance of the procedure has yet to be developed. Treatment planning prior to the day of therapy would allow adequate time for implementing advanced planning techniques such as acoustic field simulation for aberration correction 10 and acoustic obstruction avoidance, in addition to precise target delineation. Additionally, CBCT images have lower image quality than multi-detector computed tomography (MDCT) or magnetic resonance imaging (MRI) scans, 11 and have a smaller field of view, introducing visibility challenges such as truncation artifacts and incomplete liver coverage in the image volume.…”

Section: Introductionmentioning

confidence: 99%

FEM deformable liver registration to facilitate CBCT guided histotripsy

Minesinger,

Laeseke,

Kutlu

et al. 2024

Medical Imaging 2024: Physics of Medical Imaging

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Histotripsy is an emerging focal tumor therapy that utilizes focused ultrasound (US) to mechanically destroy tissue. Cone beam CT (CBCT) guidance has been developed to overcome limitations of diagnostic US for visualizing and targeting tumors. Existing workflow for CBCT-guided histotripsy utilizes targeting based on CBCT images acquired with the patient in position for treatment; therefore, treatment planning is currently performed intraprocedurally right before delivering therapy. To provide a framework for planning liver tumor treatments in advance, a biomechanical, nonrigid model is proposed to predict volumetric liver deformations between a pre-procedural diagnostic scan and the intraprocedural CBCT. In the proposed registration approach, the liver, gallbladder (GB), and hepatic blood vessels were segmented from CBCT images acquired at two different points of motion. Segmented structural surfaces were registered using a rigid iterative closest point algorithm followed by deformable registration (demons algorithm). These internal and external hepatic structural surface registrations were used as boundary conditions for a finite element model (FEM) to determine internal liver deformations. Four FEM models were constructed: the liver alone (L-FEM), liver and GB (LG-FEM), liver and vessels (LV-FEM), and liver, GB, and vessels (LGV-FEM). Registration accuracy was measured as the Euclidean distance between manually annotated vessel bifurcations. Bifurcation error was 3.5±3.5mm for LGV-FEM, a 52% improvement from L-FEM (7.4±6.1mm). Including vessels and GB in the model both individually reduced bifurcation error compared to corresponding models excluding those structures. FEM-based liver registration guided by internal and external hepatic structures is a feasible method to facilitate CBCT-guided histotripsy treatment planning.

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The art of histotripsy: a focused ultrasound application that has the potential to treat from head to toe!

LeBlang,

Ziemlewicz

2024

International Journal of Hyperthermia

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Aberration correction in abdominal histotripsy

Cited by 4 publications

References 164 publications

A target containing phantom for accuracy assessment of cone‐beam CT‐guided histotripsy

A target containing phantom for accuracy assessment of cone‐beam CT‐guided histotripsy

FEM deformable liver registration to facilitate CBCT guided histotripsy

The art of histotripsy: a focused ultrasound application that has the potential to treat from head to toe!

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