Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang, Chao

doi:10.1117/1.jbo.17.6.066016

Cited by 89 publications

(92 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Image quality can further be improved by use of advanced reconstruction algorithms that account for the presence of the skull, such as time-reversal methods. 8, 16 …”

Section: Resultsmentioning

confidence: 99%

“…Previously, PAT of the brain was successfully conducted through a monkey skull but never through a human skull. [6][7][8] Since the human skull is greatly thicker than a monkey skull, light and ultrasound will be strongly attenuated, deteriorating the image quality more severely. In this letter, we report the first demonstration of PAT through an intact adult human skull.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Photoacoustic tomography through a whole adult human skull with a photon recycler

et al. 2012

View full text Add to dashboard Cite

Abstract. Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.

show abstract

“…Image quality can further be improved by use of advanced reconstruction algorithms that account for the presence of the skull, such as time-reversal methods. 8, 16 …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photoacoustic tomography through a whole adult human skull with a photon recycler

et al. 2012

View full text Add to dashboard Cite

show abstract

“…For example, by using x-ray CT, the skull morphology and composition can be obtained and incorporated into a time-reversal-based reconstruction algorithm to correct for the skull distortion. 60 Ultrasound tomography (UST) has also been integrated into PACT to measure the acoustic properties, which were then used to inform the PACT image reconstruction. 61 With continuing advances in imaging techniques and reconstruction algorithms, we believe PACT will soon allow in vivo imaging of the deep brain in addition to the cortex.…”

Section: Discussionmentioning

confidence: 99%

Label-free photoacoustic tomography of whole mouse brain structures ex vivo

Xia

et al. 2016

Neurophoton.

View full text Add to dashboard Cite

Abstract. Capitalizing on endogenous hemoglobin contrast, photoacoustic-computed tomography (PACT), a deep-tissue high-resolution imaging modality, has drawn increasing interest in neuroimaging. However, most existing studies are limited to functional imaging on the cortical surface and the deep brain structural imaging capability of PACT has never been demonstrated. Here, we explicitly studied the limiting factors of deep brain PACT imaging. We found that the skull distorted the acoustic signal and blood suppressed the structural contrast from other chromophores. When the two effects are mitigated, PACT can potentially provide high-resolution label-free imaging of structures in the entire mouse brain. With 100-μm in-plane resolution, we can clearly identify major structures of the brain, which complements magnetic resonance microscopy for imaging small-animal brain structures. Spectral PACT studies indicate that structural contrasts mainly originate from cytochrome distribution and that the presence of lipid sharpens the image contrast; brain histology results provide further validation. The feasibility of imaging the structure of the brain in vivo is also discussed. Our results demonstrate that PACT is a promising modality for both structural and functional brain imaging.

show abstract

“…By combining features of photonics with ultrasound, photoacoustic technique improves both imaging and diagnostic potentialities of single methods [12][13][14][15][16] . Photoacoustic imaging of the brain has the potential to elucidate multiple questions in neurobiology, however, the skullcap that naturally protects the encephalon, dramatically limits both the photonic and ultrasonic tissue penetration [17][18][19] . Moreover, bones promote scattering of both light and sound resulting in loss of sensitivity and image aberrations [17][18] .…”

Section: Introductionmentioning

confidence: 99%

“…Photoacoustic imaging of the brain has the potential to elucidate multiple questions in neurobiology, however, the skullcap that naturally protects the encephalon, dramatically limits both the photonic and ultrasonic tissue penetration [17][18][19] . Moreover, bones promote scattering of both light and sound resulting in loss of sensitivity and image aberrations [17][18] . As a consequence, brain ultrasonic and photoacoustic imaging can be easily performed on neonate animals prior to ossification 20 , but the deep anatomy and physiology of the adult brain are clearly accessible only after craniotomy 21,22 .…”

Section: Introductionmentioning

confidence: 99%

Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging

Giustetto

Filippi

Castano

et al. 2015

JoVE

View full text Add to dashboard Cite

Photoacoustics and high frequency ultrasound stands out as powerful tools for neurobiological applications enabling high-resolution imaging on the central nervous system of small animals. However, transdermal and transcranial neuroimaging is frequently affected by low sensitivity, image aberrations and loss of space resolution, requiring scalp or even skull removal before imaging. To overcome this challenge, a new protocol is presented to gain significant insights in brain hemodynamics by photoacoustic and high-frequency ultrasounds imaging with the animal skin and skull intact. The procedure relies on the passage of ultrasound (US) waves and laser directly through the fissures that are naturally present on the animal cranium. By juxtaposing the imaging transducer device exactly in correspondence to these selected areas where the skull has a reduced thickness or is totally absent, one can acquire high quality deep images and explore internal brain regions that are usually difficult to anatomically or functionally describe without an invasive approach. By applying this experimental procedure, significant data can be collected in both sonic and optoacoustic modalities, enabling to image the parenchymal and the vascular anatomy far below the head surface. Deep brain features such as parenchymal convolutions and fissures separating the lobes were clearly visible. Moreover, the configuration of large and small blood vessels was imaged at several millimeters of depth, and precise information were collected about blood fluxes, vascular stream velocities and the hemoglobin chemical state. This repertoire of data could be crucial in several research contests, ranging from brain vascular disease studies to experimental techniques involving the systemic administration of exogenous chemicals or other objects endowed with imaging contrast enhancement properties. In conclusion, thanks to the presented protocol, the US and PA techniques become an attractive noninvasive performance-competitive means for cortical and internal brain imaging, retaining a significant potential in many neurologic fields.

show abstract

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Cited by 89 publications

References 38 publications

Photoacoustic tomography through a whole adult human skull with a photon recycler

Photoacoustic tomography through a whole adult human skull with a photon recycler

Label-free photoacoustic tomography of whole mouse brain structures ex vivo

Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging

Contact Info

Product

Resources

About