Aberrantly enhanced melanoma-associated antigen (MAGE)-A3 expression facilitates cervical cancer cell proliferation and metastasis via actuating Wnt signaling pathway

Gao, Xin; Chen, Guobin; Cai, Haibo; Wang, Xuefeng; Song, Kaijing; Liu, Limin; Qiu, Tianmei; He, Yun

doi:10.1016/j.biopha.2019.109710

Cited by 19 publications

(11 citation statements)

References 39 publications

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“…Recently, MAGE-A3 overexpression has been shown to induce proliferation and migration of cervical cancer cells by modulating the EMT and Wnt signaling pathways. Therefore, these studies suggest that MAGE-A genes can induce proliferation and facilitate metastasis of cancer cells [95]. Expression of MAGE-A genes has been shown to be associated with resistance to tumor necrosis factor (TNF)-α-mediated cytotoxicity in cervical cancer cells [96].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

2020

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Background Members of the melanoma-associated antigen-A (MAGE-A) subfamily are overexpressed in many cancers and can drive cancer progression, metastasis, and therapeutic recurrence. Objective This study is the first comprehensive meta-analysis evaluating the prognostic utility of MAGE-A members in different cancers. Methods A systematic literature search was conducted in PubMed, Google Scholar, Science Direct, and Web of Science. The pooled hazard ratios with 95% confidence intervals were estimated to evaluate the prognostic significance of MAGE-A expression in various cancers. Results In total, 44 eligible studies consisting of 7428 patients from 11 countries were analysed. Univariate and multivariate analysis for overall survival, progression-free survival, and disease-free survival showed a significant association between high MAGE-A expression and various cancers (P < 0.00001). Additionally, subgroup analysis demonstrated that high MAGE-A expression was significantly associated with poor prognosis for lung, gastrointestinal, breast, and ovarian cancer in both univariate and multivariate analysis for overall survival. Conclusion Overexpression of MAGE-A subfamily members is linked to poor prognosis in multiple cancers. Therefore, it could serve as a potential prognostic marker of poor prognosis in cancers.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

2020

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“…Our transcriptomic analysis upon SIN3A-PF1 perturbation in 3D culture system showed significant alteration of several genes. Matrix metalloproteases proteins (MMP1 & MMP3) known enhancers of invasion and MAGEA3, CDH11, SPOCK, PTGS2 and WNT5A, overexpressed in high grade of invasive cancer, are all downregulated in PF1-SID cells [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] . LHX8 and its family member LHX6, known to inhibit breast cancer cell proliferation by repressing WNT signaling, is the topmost upregulated gene in PF1-SID cells [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

Kadamb¹,

Leibovitch²,

Farías³

et al. 2022

Translational Oncology

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Highlights We show that the PAH2 domain of SIN3A is a target when it is inhibited from binding to PF1 results in inhibition of invasive phenotype in TNBC. Epigenetic repression of integrins expression and downstream pathways results from enhanced binding of KLF9 /SIN3A repressor complex to their promoters. Genome wide transcriptomic analysis showed downregulation of multiple invasion related genes. Tumor growth and lung metastasis were markedly decreased in vivo. Our studies highlight that PF1 might serve as a gatekeeper for trafficking SID protein binding to PAH2 of SIN3A and has functional role in presentation of different regulatory complexes. Blocking the function of PAH2 offers a promising targeted therapy approach for inhibiting the invasive phenotype in TNBC.

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“…Melanoma-associated antigen A3 (MAGEA3) enhances migration, invasion and proliferation by activation of EMT and Wnt signaling pathway in HeLa cells ( Gao et al, 2020 ). In the same way, enhanced expression of MAGEA3 was found in drug-resistant cells ( Bertram et al, 1998 ) and knockdown of MAGEA3 expression caused a reduction in proliferation and colony formation ability ( Xie et al, 2016 ).…”

Section: Micrornas Involved In Ddp-chemoresistancementioning

confidence: 99%

Contribution of MicroRNAs in Chemoresistance to Cisplatin in the Top Five Deadliest Cancer: An Updated Review

Loren

Saavedra

et al. 2022

Front. Pharmacol.

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Cisplatin (DDP) is a well-known anticancer drug used for the treatment of numerous human cancers in solid organs, including bladder, breast, cervical, head and neck squamous cell, ovarian, among others. Its most important mode of action is the DNA-platinum adducts formation, inducing DNA damage response, silencing or activating several genes to induce apoptosis; these mechanisms result in genetics and epigenetics modifications. The ability of DDP to induce tumor cell death is often challenged by the presence of anti-apoptotic regulators, leading to chemoresistance, wherein many patients who have or will develop DDP-resistance. Cancer cells resist the apoptotic effect of chemotherapy, being a problem that severely restricts the successful results of treatment for many human cancers. In the last 30 years, researchers have discovered there are several types of RNAs, and among the most important are non-coding RNAs (ncRNAs), a class of RNAs that are not involved in protein production, but they are implicated in gene expression regulation, and representing the 98% of the human genome non-translated. Some ncRNAs of great interest are long ncRNAs, circular RNAs, and microRNAs (miRs). Accumulating studies reveal that aberrant miRs expression can affect the development of chemotherapy drug resistance, by modulating the expression of relevant target proteins. Thus, identifying molecular mechanisms underlying chemoresistance development is fundamental for setting strategies to improve the prognosis of patients with different types of cancer. Therefore, this review aimed to identify and summarize miRs that modulate chemoresistance in DDP-resistant in the top five deadliest cancer, both in vitro and in vivo human models.

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Aberrantly enhanced melanoma-associated antigen (MAGE)-A3 expression facilitates cervical cancer cell proliferation and metastasis via actuating Wnt signaling pathway

Cited by 19 publications

References 39 publications

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

Contribution of MicroRNAs in Chemoresistance to Cisplatin in the Top Five Deadliest Cancer: An Updated Review

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