Aberrant tetranectin expression in human breast carcinomas as a predictor of survival

Obrist, Peter; Spizzo, Gilbert; Ensinger, Christian; Fong, Dong; Brunhuber, Thomas; Schäfer, Georg; Varga, M; Margreiter, Raimund; Amberger, Albert; Gastl, Guenther; Christiansen, Michael

doi:10.1136/jcp.2003.010058

Cited by 31 publications

(33 citation statements)

References 38 publications

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“…It is also believed to play a critical role in mineralization during osteogenesis and in myogenesis during embryonic development [19]. Furthermore, TN has been implicated as a potential biomarker in conditions ranging from cancer to Parkinson's disease [20]. The present results, detected by 2-DE and confirmed by western blotting, showed that the expression of TN in the CAA samples was significantly lower compared to healthy controls.…”

Section: Discussionsupporting

confidence: 64%

Proteomics study of serum exosomes in Kawasaki disease patients with coronary artery aneurysms

Xie

Chu

et al. 2019

Cardiol J.

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Section: Discussionsupporting

confidence: 64%

Proteomics study of serum exosomes in Kawasaki disease patients with coronary artery aneurysms

Xie

Chu

et al. 2019

Cardiol J.

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“…To date, the biological function of tetranectin has not been fully elucidated [26]. One previous study indicated that tetranectin was involved in the degradation of extracellular matrix proteins in the brain [27].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation

Wang

Yao

Chen

et al. 2013

Cell Physiol Biochem

858

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Aims: To investigate alterations in protein expression associated with deep brain stimulation (DBS) in an attempt to elucidate possible mechanisms of action. Methods: Cerebrospinal fluid (CSF), obtained from six Parkinson's disease (PD) patients (pre- and post-DBS) and from six normal healthy controls, was studied for differentially expressed proteins. 2-D DIGE, in combination with MALDI-TOF and TOF-TOF Mass Spectrometry (MS) or ESI-MS, was used to identify the changed proteins (3 PD patients and 3 controls). Selected proteins were further studied using western blotting (6 PD patients and 6 controls). Results: Twenty-one proteins were identified after MS and protein database interrogation. Apart from apolipoprotein A-I (apoA-I), the expression levels of complement C4 (C4), IgA, tetranectin, and extracellular superoxide dismutase (EC-SOD), detected by western blotting, correlated well with the 2-D DIGE results. In the follow-up period, the expression levels of C4, apoA-I and IgA were stable whereas EC-SOD and tetranectin were significantly elevated. In addition, when DBS was ceased in one patient due to a suicide attempt, the levels of EC-SOD and tetranectin significantly decreased. Conclusion: Our preliminary results suggest that variations in the expression levels of EC-SOD and tetranectin in CSF is related to DBS.

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“…In malignancies, TN has been detected in the stroma and in tumor cells of different tumor types with varying distribution patterns [1,6,10,11,21,23,25]. In breast cancer, mainly cytoplasmic staining was found [6,21], while in other tumors, TN expression was predominantly or even completely restricted to the tumor stroma [1,10,11,23,25].…”

Section: Introductionmentioning

confidence: 99%

“…In breast cancer, mainly cytoplasmic staining was found [6,21], while in other tumors, TN expression was predominantly or even completely restricted to the tumor stroma [1,10,11,23,25]. TN is thought to enhance proteolytic processes through activation of the plasminogen-cascade, enabling tumor cells invasion and metastasizing [10,23,25].…”

Section: Introductionmentioning

confidence: 99%

Expression and prognostic significance of Tetranectin in invasive and non-invasive bladder cancer

et al. 2007

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Tetranectin (TN) is a plasminogen kringle-4 binding protein that can be detected in the plasma and the extracellular matrix. In malignancies, TN is thought to enhance proteolytic processes enabling tumor cells to invade and metastasize. So far, TN expression has not been described in transitional cell bladder cancer (TCC), and there is no information on the prognostic significance of its in situ expression. TN expression was studied in 99 TCC patients diagnosed between 1994 and 1997. Immunohistochemistry was performed on a tissue microarray using a monoclonal antibody against TN (clone 11F1). Within the mean follow-up period of 60 months, pTa and pT2-4 TCC patients with stainable TN in the tumor stroma had a significant shorter recurrence-free survival and higher risk of recurrence compared to those without stainable TN (p = 0.0002 for both). TN expression in the tumor cells did not influence recurrence-free survival. In conclusion, TN is expressed in a subgroup of bladder cancer patients with a higher risk of recurrence who may take benefit from a closer follow-up.

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Aberrant tetranectin expression in human breast carcinomas as a predictor of survival

Cited by 31 publications

References 38 publications

Proteomics study of serum exosomes in Kawasaki disease patients with coronary artery aneurysms

Proteomics study of serum exosomes in Kawasaki disease patients with coronary artery aneurysms

Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation

Expression and prognostic significance of Tetranectin in invasive and non-invasive bladder cancer

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