Aberrant static and dynamic functional connectivity of the executive control network in lung cancer patients after chemotherapy: a longitudinal fMRI study

Hu, Lingyu; Chen, Huiyou; Su, Wen; Zhang, Yujie; You, Jia; Gu, Wei; Xiong, Zhenyu; Yin, Xindao; Chen, Yu‐Chen

doi:10.1007/s11682-020-00287-6

Cited by 11 publications

(11 citation statements)

References 61 publications

(74 reference statements)

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“…Further studies are required to find the most appropriate brain parcellation strategy or spatial scale for the characterization of network topology as different parcellation schemes or as different spatial scales exhibit distinct topological architectures. Furthermore, Hu et al revealed that the functional connectivity within the executive control network was reduced in lung cancer patients after chemotherapy with dynamic connectivity analysis ( 8 ). So far, there have been a few studies on lung cancer patients before or after chemotherapy using brain dynamic network.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies about brain function changes in lung cancer patients have demonstrated the feasibility of fMRI ( 5 , 6 ). You et al reported that the dynamic brain activity of patients with chemotherapy significantly decreased in the default-mode network (DMN) region ( 7 ), and Hu et al found that the dynamic functional connectivity variability in patients with chemotherapy was significantly reduced in several brain regions ( 8 ). Simo et al also reported the DMN functional connectivity decreases in patients with lung cancer ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy

You

Zhang²,

Shang

et al. 2021

Front. Neurol.

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Purpose: This study aimed to explore the topological features of brain functional network in lung cancer patients before and after chemotherapy using graph theory.Methods: Resting-state functional magnetic resonance imaging scans were obtained from 44 post-chemotherapy and 46 non-chemotherapy patients as well as 49 healthy controls (HCs). All groups were age- and gender-matched. Then, the topological features of brain functional network were assessed using graph theory analysis.Results: At the global level, compared with the HCs, both the non-chemotherapy group and the post-chemotherapy group showed significantly increased values in sigma (p < 0.05), gamma (p < 0.05), and local efficiency, Eloc (p < 0.05). The post-chemotherapy group and the non-chemotherapy group did not differ significantly in the above-mentioned parameters. At the nodal level, when non-chemotherapy or post-chemotherapy patients were compared with the HCs, abnormal nodal centralities were mainly observed in widespread brain regions. However, when the post-chemotherapy group was compared with the non-chemotherapy group, significantly decreased nodal centralities were observed primarily in the prefrontal–subcortical regions.Conclusions: These results indicate that lung cancer and chemotherapy can disrupt the topological features of functional networks, and chemotherapy may cause a pattern of prefrontal–subcortical brain network abnormality. As far as we know, this is the first study to report that altered functional brain networks are related to lung cancer and chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy

You

Zhang²,

Shang

et al. 2021

Front. Neurol.

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“…In addition, the connections between the inferior frontal gyrus and subcortical regions were found to be involved in the executive processing ( 62 ). Decreased functional connectivity between the left inferior frontal gyrus (triangular part) and dorsolateral prefrontal cortex was found in patients with lung cancer after chemotherapy when compared with HC while decreased functional connectivity between the left inferior frontal gyrus and the right dorsolateral prefrontal cortex was identified in patients with lung cancer after chemotherapy when compared with those before treatment ( 6 ). Abnormal functional connectivity between these two brain regions was found to be correlated to the worse neuropsychologic performance of patients with cancer ( 63 ).…”

Section: Discussionmentioning

confidence: 99%

“…Although lung cancer has not been associated historically with abnormalities of the central neural system, an increasing body of evidence suggests that patients with lung cancer may be associated with neurocognitive impairments (2)(3)(4)(5). Survivors of lung cancer have a high incidence of cognitive deficits, such as executive function and working memory (6)(7)(8). The above problems may be caused by chemotherapy or by altered brain functional activity associated with cancer (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer

Liu

Yin

et al. 2022

Front. Neurol.

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IntroductionSome previous studies in patients with lung cancer have mainly focused on exploring the cognitive dysfunction and deficits of brain function associated with chemotherapy. However, little is known about functional brain alterations that might occur prior to chemotherapy. Therefore, this study aimed to evaluate brain functional changes in patients with nonchemotherapy before chemotherapy with non-small cell lung cancer (NSCLC).MethodsResting-state functional MRI data of 35 patients with NSCLC and 46 matched healthy controls (HCs) were acquired to construct functional brain networks. Graph theoretical analysis was then applied to investigate the differences of the network and nodal measures between groups. Finally, the receiver operating characteristic (ROC) curve analysis was performed to distinguish between NSCLC and HC.ResultsDecreased nodal strength was found in the left inferior frontal gyrus (opercular part), inferior frontal gyrus (triangular part), inferior occipital gyrus, and right inferior frontal gyrus (triangular part) of patients with NSCLC while increased nodal strength was found in the right pallidum and thalamus. NSCLC also showed decreased nodal betweenness in the right superior occipital gyrus. Different hub regions distribution was found between groups, however, no hub regions showed group differences in the nodal measures. Furthermore, the ROC curve analysis showed good performance in distinguishing NSCLC from HC.ConclusionThese results suggested that topological abnormalities of pallido-thalamo-cortical circuit in functional brain network might be related to NSCLC prior to chemotherapy, which provided new insights concerning the pathophysiological mechanisms of NSCLC and could serve as promising biological markers for the identification of patients with NSCLC.

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“…Functional studies have demonstrated the reduced resting-state FC pattern within the DMN and the cognitive disorder are associated with cancer and chemotherapy in patients with lung cancer ( Simó et al, 2018 ; Zhang Y. et al, 2020 ). Hu et al (2020) explored links between changes in the intrinsic static and dynamic functional connectivity in the executive control network (ECN) patterns and chemotherapy in patients with lung cancer. For such controversial results, more advanced research methods should be used to solve these problems.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy

Zhang

Shang

et al. 2022

Front. Mol. Biosci.

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Purpose: This study was performed to investigate the regional cerebral blood flow (CBF) and CBF connectivity in the chemotherapy-induced cognitive impairment of patients with lung cancer by using arterial spin labeling.Methods: Pseudocontinuous arterial spin labeling perfusion magnetic resonance imaging and neuropsychological tests were performed for 21 patients with non-small cell lung cancer who had received chemotherapy CT (+) and 25 non-small cell lung cancer patients who need chemotherapy but did not yet received CT (-). The CT (+) group previously received platinum-based therapy for 3 months to 6 months (the time from their first chemotherapy to the MRI scan). Group comparisons were performed in the regional normalized CBF and CBF connectivity, and the relationship between the regional normalized CBF and cognitive impairment were detected.Results: The CT (+) group exhibited higher CBF in the left insula, right caudate, right superior occipital gyrus, left superior temporal gyrus (STG), and right middle frontal gyrus (MFG). MoCA scores as well as the memory scores were negatively correlated with the increased CBF in the right MFG (r = −0.492, p = 0.023; r = −0.497, p = 0.022). Alterations in the CBF connectivity were detected only in the CT (+) group between the following: right MFG and the right precentral gyrus; the right caudate and the right lingual gyrus; right caudate and right precuneus; left STG and the bilateral MFG; and the left STG and the right middle cingulum.Conclusion: These findings indicated that chemotherapy is associated with abnormalities in the CBF and connectivity alterations, which may contribute to the cognitive impairment in patients with lung cancer.

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Aberrant static and dynamic functional connectivity of the executive control network in lung cancer patients after chemotherapy: a longitudinal fMRI study

Cited by 11 publications

References 61 publications

Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy

Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy

Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer

Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy

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