Aberrant salience network (bilateral insula and anterior cingulate cortex) connectivity during information processing in schizophrenia

White, Thomas P.; Joseph, Verghese; Francis, Susan T.; Liddle, Peter F.

doi:10.1016/j.schres.2010.07.020

Cited by 210 publications

(176 citation statements)

References 33 publications

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“…In addition, our findings are in line with those from previous studies on the perception of others' pain that have shown activation in regions of the cingulate (Höfle et al, 2013) and sensorimotor (Cheng et al, 2008;Whitmarsh et al, 2011) cortices, as well as in posterior brain regions, including the FG (Höfle et al, 2013;Singer et al, 2004). Finally, similar to previous reports, we found a Bpain effect^also in the STG (Botvinick et al, 2005;Singer et al, 2004), a region associated with salience (Hayes, Hayes, & Mikedis, 2012;White, Joseph, Francis, & Liddle, 2010) and social information processing (Bernhardt & Singer, 2012), which was extended to the posterior insula, which is known to be associated with the sensory experience of pain (Peyron et al, 2000;Sabatini et al, 2009).…”

Section: Discussionsupporting

confidence: 93%

Prior exposure to extreme pain alters neural response to pain in others

Eidelman-Rothman

Goldstein

Weisman

et al. 2016

Cogn Affect Behav Neurosci

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In the extant literature examining the brain mechanisms implicated in pain perception, researchers have theorized that the overlapping responses to pain in the self and in others mark the human capacity for empathy. Here we investigated how prior exposure to extreme pain affects pain perception, by assessing the dynamics of pain processing in veterans who were previously exposed to severe injury. Fortythree participants (28 pain-exposed and 15 controls) underwent whole-head magnetoencephalography (MEG) while viewing photographs of limbs in painful and nonpainful (neutral) conditions. Among controls, an early (0-220 ms) Bpain effect^in the posterior cingulate and sensorimotor cortices, and a later (760-900 ms) Bpain effect^in the posterior cingulate cortex, superior temporal gyrus/insula, and fusiform gyrus were found, indicated by enhanced alpha suppression to the pain versus nonpain conditions. Importantly, pain-exposed participants exhibited an atypical pain response in the posterior cingulate cortex, indicated by a normative response to pain, but no pain-to-no-pain differentiation. This may suggest that individuals exposed to extreme pain may perceive neutral stimuli as potentially threatening. Our findings demonstrate alterations in pain perception following extreme pain exposure, chart the sequence from automatic to evaluative pain processing, and emphasize the importance of considering past experiences in studying the neural response to others' states.

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Section: Discussionsupporting

confidence: 93%

Prior exposure to extreme pain alters neural response to pain in others

Eidelman-Rothman

Goldstein

Weisman

et al. 2016

Cogn Affect Behav Neurosci

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“…36,37 Abnormal functional connectivity in the anterior cingulate cortex, which is part of the salience network, may account for impairments in cognitive control and detecting stimuli salience. 38,39 Functional dysconnectivity is known to be widespread in patients with schizophrenia, and our findings accordingly revealed alterations in the premotor cortex, basal ganglia 40,41 and cerebellum. 42,43 Deficient cerebellar function, for instance, has been associated with high-order cognitive deficits in patients with schizophrenia, as proposed in the "cognitive dysmetria" model of schizophrenia.…”

Section: A B Csupporting

confidence: 50%

Altered brain connectivity in patients with schizophrenia is consistent across cognitive contexts

Orban

Desseilles

Mendrek

et al. 2017

JPN

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IntroductionBeyond abnormal activity of focal brain areas, 1 aberrant functional interactions between brain regions are thought to be a core feature of schizophrenia. [2][3][4] Among the current issues related to this influential idea is whether abnormal functional connectivity in patients with schizophrenia is contextdependent. 5 Resting-state fMRI characterizes intrinsic functional brain connectivity, which is guided by endogenous processes and spontaneous thoughts in the absence of any explicit task. 6 Resting-state functional brain imaging in patients with schizophrenia has revealed a widespread functional dysconnectivity between brain regions that are also known to exhibit abnormal levels of activation in relation to impairments in task performance and/or symptomatology. 7-11However, a critical issue with the study of resting-state functional connectivity in patients with schizophrenia is the poor control over the cognitive state of these individuals, which may confound the interpretation of the results. Patients with schizophrenia experience pronounced disturbances of thoughts and differ from controls with regards to their internal mentations and cognitive states during rest. 12 The question of the context-independence of abnormal functional connectivity in patients with schizophrenia may thus be best adressed by characterizing such alterations using well-defined behavioural paradigms. To date, research has focused on determining whether alterations in brain connectivity were further modulated by task complexity in single cognitive domains. 13-15However, to our knowledge, there is no sufficiently powered study that specifically examined commonalities and differences in dysconnectivity across distinct cognitive tasks. 16In the present work, we sought to assess whether the degree of cognitive similarity would impact the results by looking at 2 cognitive domains that strongly differ from one another, emotional versus visuomotor processing. We further distinguished the emotional processing task based on an additional embedded component, either incidental learning or recognition memory. These 3 paradigms were studied with a connectome-wide general linear model analysis. We characterized context-independent effects through commonalities in the main effects of abnormal functional connectivity across the 3 tasks. We evaluated context-dependent effects of abnormal connectivity using interaction analyses that looked for changes in functional connectivity between tasks in patients Correspondence to: P. Orban, CRIUGM, Université de Montréal, 4545 Queen Mary, Montreal, QC H3W 1W5; pierre.orban@criugm.qc.ca Submitted July 13, 2015; Revised Nov. 19, 2015; Accepted Jan. 5, 2016; Early-released Apr. 19, 2016 DOI: 10.1503 Background: Schizophrenia has been defined as a dysconnection syndrome characterized by aberrant functional brain connectivity. Using task-based fMRI, we assessed to what extent the nature of the cognitive context may further modulate abnormal functional brain connectivity. Methods: We analyzed data matc...

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“…More direct evidence for an impaired interaction between the salience network and the DMN comes from a functional connectivity analysis of independent components in the same sample. 104 Notably, failure to deactivate the DMN has been shown previously in various resting state studies of patients with schizophrenia and their relatives. [105][106][107] In summary, disrupted functional connectivity is noted across the insula and ACC in individuals with schizophrenia.…”

Section: Functional Mri Studies Of Schizophreniamentioning

confidence: 74%