Aberrant pro-inflammatory responses of CD20+ T cells in experimental arthritis

Pan, Piaopiao; Pineda, Miguel; Wang, Yilin; Khan, Aneesah; Nyirenda, Mukanthu

doi:10.1016/j.cellimm.2023.104717

Cited by 1 publication

(3 citation statements)

References 51 publications

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“…However, there are some reports of CD20 being expressed by some T cells, which are called CD20-expressing T cells (CD3 + CD20 + T cells). CD20-expressing T cells were first reported in T cell lymphoma [ 129 ], RA [ 130 ] and animal-model experimental arthritis (EA) [ 131 ], MS [ 126 , 132 – 136 ], EAE [ 136 ], and neuromyelitis optical spectrum disorder (NMOSD) [ 132 ], as well as in healthy individuals (3–5% of all CD3 + cells) [ 137 ]. Furthermore, CD3 + B cells have been reported [ 138 ].…”

Section: Cd20-expressing T Cells (Or Cd20 + T Cell...mentioning

confidence: 99%

“…Recently, a novel subset of CD8 T cells, CXCR5 + CD8 + T cells, were identified [ 141 – 143 ]. CXCR5 + CD8 + T cells have been found to infiltrate the B cell follicle in response to several diseases, including viral infection (simian immunodeficiency virus (SIV) or human immunodeficiency virus (HIV) [ 144 – 170 ], lymphocytic choriomeningitis virus (LCMV) [ 149 , 171 , 172 ], hepatitis B virus (HBV) [ 173 – 180 ], polycythemia-inducing FV [ 180 ], FluA [ 181 , 182 ], HSV [ 183 ], DENV2 [ 184 , 185 ], and SARS CoV-2 [ 186 – 190 ], EBV [ 191 ]); cancer (colorectal cancer [ 192 – 194 ], NCLC [ 195 ], hepatocellular carcinoma [ 175 , 196 ], hematologic malignancies [ 197 ], pancreatic tumors [ 198 ], gastric cancer [ 199 ], breast cancer [ 200 ], thyroid cancer [ 201 ], melanoma [ 202 ], and lymphoma [ 203 ]); bacterial infection ( Escherichia coli , Acinetobacter baumannii , Klebsiella pneumonia , Pseudomonas aeruginosa , and Staphylococcus aureus [ 204 ]); parasitic infection ( Leishmania mexicana [ 205 ]); immunodeficiency disease (CVID [ 206 ]); autoimmune diseases [ 4 , 131 , 207 – 210 ] (rheumatoid arthritis (RA) [ 131 , 207 ] [ 211 ], primary Sjögren syndrome (pSS) [ 208 ] [ 212 ], and multiple sclerosis (MS) [ 210 , 213 ]).…”

Section: Cxcr5 + Cd8 + T Cells ...mentioning

confidence: 99%

“…CXCR5 + CD8 T cells have special phenotypes: for example, 1) cell markers including CD11a, CD11b, CD20, CD25, CD27, CD28, CD38, CD39, CD40, CD43, CD44hi, CD45RA, CD45RO, CD57, CD62L, CD69, CD83, CD94, CD95, CD101, CD103, CXCR5,CD107, CD127, CD137, CD161, CD200, CD244, HLA-DR, 41BBL, Slamf6, and TCRVa7.2 [ 13 , 131 , 145 , 146 , 149 , 151 – 155 , 157 – 160 , 163 – 165 , 167 , 168 , 171 , 174 , 176 – 178 , 180 – 182 , 184 – 190 , 193 – 195 , 197 , 199 , 201 , 204 , 205 , 207 , 211 , 212 , 214 ]; 2) cytokines, chemokines and receptors (CSF-1, IL-2, IL-4, IL-6, IL-7, IL-7R, IL-10, IL-17, IL-18Ra, IL-21, IL-21R, IL-22, IL-23, IL-27, IL-27R, IL-35, IFN-I, IFNAR1, IFN-γ, TGF-β, TNF-α, IL-4R (CD124), CCR2, CCR4, CCR5, CCR6, CCR7, CCR9, CCL5, CXCL1, CXCL5, CXCL10, CXCL12 (SDF-1α), CXCL13, CXCR3, CXCR4, CXCR5, CX3CR1, MIP-1β) [ 144 – 146 , 149 , 151 , 153 , 154 , 157 , 159 – 162 , 165 , 167 , 168 , 170 , 172 – 174 , 176 , 177 , 179 , 181 – 186 , 188 , 190 , 191 , 193 – 197 , 199 , 200 , 205 , 206 , …”

Section: Cxcr5 + Cd8 + T Cells ...mentioning

confidence: 99%

See 2 more Smart Citations

An angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis

Peng,

Yang,

Chen

et al. 2024

J Transl Med

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Background Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtypes of CD4+ T cells, including T helper (Th) 17 cells, follicular Th cells, and regulatory T cells (Tregs), contribute to the pathogenesis of MG. However, increasing evidence suggests that CD8+ T cells also play a critical role in the pathogenesis and treatment of MG. Main body Herein, we review the literature on CD8+ T cells in MG, focusing on their potential effector and regulatory roles, as well as on relevant evidence (peripheral, in situ, cerebrospinal fluid, and under different treatments), T-cell receptor usage, cytokine and chemokine expression, cell marker expression, and Treg, Tc17, CD3+CD8+CD20+ T, and CXCR5+ CD8+ T cells. Conclusions Further studies on CD8+ T cells in MG are necessary to determine, among others, the real pattern of the Vβ gene usage of autoantigen-specific CD8+ cells in patients with MG, real images of the physiology and function of autoantigen-specific CD8+ cells from MG/EAMG, and the subset of autoantigen-specific CD8+ cells (Tc1, Tc17, and IL-17+IFN-γ+CD8+ T cells). There are many reports of CD20-expressing T (or CD20 + T) and CXCR5+ CD8 T cells on autoimmune diseases, especially on multiple sclerosis and rheumatoid arthritis. Unfortunately, up to now, there has been no report on these T cells on MG, which might be a good direction for future studies.

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