Aberrant patterns of default‐mode network functional connectivity associated with metabolic syndrome: A resting‐state study

Rashid, Barnaly; Dev, Sheena I.; Esterman, Michael; Schwarz, Nicolette F.; Ferland, Tori; Fortenbaugh, Francesca C.; Milberg, William; McGlinchey, Regina E.; Salat, David H.; Leritz, Elizabeth C.

doi:10.1002/brb3.1333

Cited by 18 publications

(11 citation statements)

References 102 publications

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“…Previously, it has been shown that higher levels of blood cholesterol and diastolic blood pressure were associated with a reduction of RSFC over time in the DMN and in global RSFC, respectively ( Köbe et al, 2021 ). Together, the earlier and present longitudinal findings converge very well with the existing (mostly cross-sectional) studies, indicating a greater vulnerability of higher-order brain networks to a variety of VRF including higher levels of blood pressure, cholesterol, and HbA1c as well as the metabolic syndrome ( Li et al, 2015 ; Zhang et al, 2016 ; Rashid et al, 2019 ; Feng et al, 2020 ; Veldsman et al, 2020 ). As in the previous study ( Köbe et al, 2021 ), a similar association was not found for BMI.…”

Section: Discussionsupporting

confidence: 88%

Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults

Wirth

Gaubert

Köbe

et al. 2022

Front. Integr. Neurosci.

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BackgroundPoor vascular health may impede brain functioning in older adults, thus possibly increasing the risk of cognitive decline and Alzheimer’s disease (AD). The emerging link between vascular risk factors (VRF) and longitudinal decline in resting-state functional connectivity (RSFC) within functional brain networks needs replication and further research in independent cohorts.MethodWe examined 95 non-demented older adults using the IMAP+ cohort (Caen, France). VRF were assessed at baseline through systolic and diastolic blood pressure, body-mass-index, and glycated hemoglobin (HbA1c) levels. Brain pathological burden was measured using white matter hyperintensity (WMH) volumes, derived from FLAIR images, and cortical β-Amyloid (Aβ) deposition, derived from florbetapir-PET imaging. RSFC was estimated from functional MRI scans within canonical brain networks at baseline and up to 3 years of follow-up. Linear mixed-effects models evaluated the independent predictive value of VRF on longitudinal changes in network-specific and global RSFC as well as a potential association between these RSFC changes and cognitive decline.ResultsWe replicate that RSFC increased over time in global RSFC and in the default-mode, salience/ventral-attention and fronto-parietal networks. In contrast, higher diastolic blood pressure levels were independently associated with a decrease of RSFC over time in the default-mode, salience/ventral-attention, and fronto-parietal networks. Moreover, higher HbA1c levels were independently associated with a reduction of the observed RSFC increase over time in the salience/ventral-attention network. Both of these associations were independent of brain pathology related to Aβ load and WMH volumes. The VRF-related changes in RSFC over time were not significantly associated with longitudinal changes in cognitive performance.ConclusionOur longitudinal findings corroborate that VRF promote RSFC alterations over time within higher-order brain networks, irrespective of pathological brain burden. Altered RSFC in large-scale cognitive networks may eventually increase the vulnerability to aging and AD.

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Section: Discussionsupporting

confidence: 88%

Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults

Wirth

Gaubert

Köbe

et al. 2022

Front. Integr. Neurosci.

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“…In fact, regions projecting positively into the leading eigenvector in the DBS-state, such as the anterior cingulate cortex [37]–[39], middle frontal gyrus [40], inferior parietal cortex [38], [40], [41], isthmus cingulate cortex [42], orbitofrontal cortex [38], middle temporal gyrus [40], [43], [44], precuneus cortex [37], [39], [40], superior frontal gyrus [45]– [47], and thalamus [37] are reported in the literature as part of the DMN. Moreover, owing to that the DBS-state comprises many frontoparietal areas, including the superior frontal gyrus (coincident with the pre-supplementary motor area) [48], middle frontal gyrus, middle temporal gyrus, inferior parietal cortex [46], [49], and precuneus [46], [47], it makes sense that this PL state also significantly correlates with the FPN.…”

Section: Resultsmentioning

confidence: 99%

“…The DBS-state comprises an extensive network of intrinsic functional connectivity consisting of distinct brain regions commonly reported as part of the DMN such as the anterior cingulate cortex [37]- [39], middle frontal gyrus [40], inferior parietal cortex [38], [40], [41], isthmus cingulate cortex [42], orbitofrontal cortex [38], middle temporal gyrus [40], [43], [44], precuneus cortex [37], [39], [40], superior frontal gyrus [45]- [47], and thalamus [37].…”

Section: Stn-dbs Modulates the Dmn In Patients With Pdmentioning

confidence: 99%

Deep brain stimulation modulates the dynamics of resting-state networks in patients with Parkinson’s Disease

Fernandes

Cabral

2020

Preprint

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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is increasingly used for the treatment of Parkinson's Disease (PD) but, despite its success, the neural mechanisms behind this surgical procedure remain partly unclear. As one working hypothesis, it was proposed that DBS works by restoring the balance of the brain's resting-state networks (RSNs), which is reported to be disrupted in people with PD. Hence, to elucidate the effects that STN-DBS induces on disseminated networks, we analyzed an fMRI dataset of 20 PD patients at rest under DBS ON and OFF conditions. Moving beyond 'static' functional connectivity studies, we employ a recently developed fMRI analysis tool, the Leading Eigenvector Dynamic Analysis (LEiDA), to characterize the recurrence of brain-wide phase-locking patterns overlapping with known RSNs. Here, STN-DBS seems to increase the Default Mode Network (DMN) occurrence in individuals with PD. Since the DMN is usually disturbed in PD patients presenting deficits in cognition, our observation might be suggestive that STN-DBS contributes to a normalization of the PD-induced cognitive impairment. Moreover, we addressed the effects of DBS lead placement on RSNs balance, considering the volume of tissue activated in 3 STN subsections. We found that the Visual Network (VN) probability of occurrence increased proportionally to the volume of tissue stimulated in the limbic part of the STN. Our finding might be indicative that stimulation of the limbic STN is closely related to the stabilization of visual symptoms sometimes presented by PD patients, which are usually accompanied by VN disruption. Overall, this study offers new insights into the fine-grained temporal dynamics of brain states portraying the effects of STN-DBS in patients with PD, while at the same time trying to pave the way to improved planning strategies for this surgical procedure.

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“…In addition, we further revealed the different cerebello-DMN connection pattern between SCZ-nMetS and SCZ-MetS. On the other hand, DMN also appeared to be especially vulnerable to metabolic abnormalities [ 55 , 56 ]. Disrupted resting state FC within DMN related to burden of vascular was implicated in cognitive function [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, DMN also appeared to be especially vulnerable to metabolic abnormalities [ 55 , 56 ]. Disrupted resting state FC within DMN related to burden of vascular was implicated in cognitive function [ 56 , 57 ]. Overall, cerebellar-DMN FC could, respectively, underlie two possible patterns of mechanism: change of psychiatric symptom and adverse influence of metabolic syndrome on cerebral connectivity states.…”

Section: Discussionmentioning

confidence: 99%

Intrinsic Therapeutic Link between Recuperative Cerebellar Con-Nectivity and Psychiatry Symptom in Schizophrenia Patients with Comorbidity of Metabolic Syndrome

Zhou

Liu

et al. 2023

Life

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Components of metabolic syndrome might be predictors of the therapeutic outcome of psychiatric symptom in schizophrenia, whereas clinical results are inconsistent and an intrinsic therapeutic link between weaker psychiatric symptoms and emergent metabolic syndrome remains unclear. This study aims to reveal the relationship and illustrate potential mechanism by exploring the alteration of cerebellar functional connectivity (FC) in schizophrenia patients with comorbidity metabolic syndrome. Thirty-six schizophrenia patients with comorbidity of metabolic syndrome (SCZ-MetS), 45 schizophrenia patients without metabolic syndrome (SCZ-nMetS) and 39 healthy controls (HC) were recruited in this study. We constructed FC map of cerebello-cortical circuit and used moderation effect analysis to reveal complicated relationship among FC, psychiatric symptom and metabolic disturbance. Components of metabolic syndrome were significantly correlated with positive symptom score and negative symptom score. Importantly, the dysconnectivity between cognitive module of cerebellum and left middle frontal gyrus in SCZ-nMetS was recuperative increased in SCZ-MetS, and was significantly correlated with general symptom score. Finally, we observed significant moderation effect of body mass index on this correlation. The present findings further supported the potential relationship between emergence of metabolic syndrome and weaker psychiatric symptom, and provided neuroimaging evidence. The mechanism of intrinsic therapeutic link involved functional change of cerebello-cortical circuit.

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Aberrant patterns of default‐mode network functional connectivity associated with metabolic syndrome: A resting‐state study

Cited by 18 publications

References 102 publications

Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults

Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults

Deep brain stimulation modulates the dynamics of resting-state networks in patients with Parkinson’s Disease

Intrinsic Therapeutic Link between Recuperative Cerebellar Con-Nectivity and Psychiatry Symptom in Schizophrenia Patients with Comorbidity of Metabolic Syndrome

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