Aberrant movement‐related somatosensory cortical activity mediates the extent of the mobility impairments in persons with cerebral palsy

Trevarrow, Michael P.; Taylor, Brittany K.; Reelfs, Anna; Wilson, Tony W.; Kurz, Max J.

doi:10.1113/jp282898

Cited by 6 publications

(1 citation statement)

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“…Having shown that age dependent decreases in hyposensitivity were most prominent for individuals with the greatest functional limitations, we wondered how sensory modality specific changes correlated to related functional areas. For example, prior work suggested aberrant tactile perception drives mobility impairments 26 . Interestingly, tactile hypo-sensitivity had the strongest correlation with age (R 2 = 0.29, Figure 6A) as compared to hyposensitivity related to the vision (R 2 = 0.17, Figure 6B), auditory (R 2 = 0.11, Figure 6C) and proprioception (R 2 = 0.11, Figure 6D) modalities.…”

Section: Individuals With Cp Exhibit Both Hyper and Hypo Sensitivity ...mentioning

confidence: 99%

Sensory symptoms across the lifespan in people with cerebral palsy

Lyons-Warren

Barber

Thomas

et al. 2023

Preprint

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AIM: To estimate prevalence of sensory symptoms in people with cerebral palsy (CP) across the lifespan. METHOD: In this cross-sectional study, the self-reported Sensory Processing Scale Inventory (SPS-I) was administered via REDCap between 2/1/22 and 8/15/22 to people with CP or their caregivers enrolled in the online MyCP Community Registry. We determined the association between SPS-I scores and age (Pearson correlation) and functional status as assessed using five validated functional classification systems for CP (ANOVA). We hypothesized that sensory symptoms would differ between younger and older individuals with CP. RESULTS: Of 155 responses (28% response rate, age 1-76 years, 34% male), 97% reported at least one bothersome sensory symptom. Total sensory symptoms decreased with age (R2=0.12, p<0.0001), driven by decreases in hyposensitivity symptoms (R2=0.32, p<0.0001), primarily tactile hyposensitivity (R2=0.29, p<0.0001). Sensory symptoms increased with greater functional impairment across all functional domains (ANOVA, p<0.0001). However, the age-specific decrease in hypo-sensitivities was most pronounced in people with the greatest gross motor functional impairment (R2=0.70, p=0.0004). INTERPRETATION: Our findings suggest that hypo-sensitivity, primarily tactile sensitivity, decreases with age in people with CP. Future work should assess whether decreased hyposensitivity contributes to other age-related changes in CP like increased pain.

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Section: Individuals With Cp Exhibit Both Hyper and Hypo Sensitivity ...mentioning

confidence: 99%