Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan

Hsu, Li Sung; Chau, Gar Yang; Yin, Pen Hui; Wen, Chin; Lui, Wing Yiu

doi:10.3892/or.15.2.507

Cited by 28 publications

(28 citation statements)

References 36 publications

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“…This was found also in colorectal cancer cells and cancer associated cells (fibroblasts and endothelial cells) in comparison with normal tissue (17). In line with these findings in colorectal cancer, there is similar expression in other gastrointestinal cancers such as gastric cancer (19,36) and hepatocellular cancer (18). Regarding the colorectal cancer cell lines LIM1215, HT29, SKCO1, SKCO17 and LoVo, there is high expression of EDNRA and low expression of EDNRB in comparison to normal colon (35).…”

Section: Variation Of Endothelin Axis Components' Expression In Colorsupporting

confidence: 71%

“…Endothelin receptors type B is considered as the predominant receptor in normal colon, but in colon cancer it is down-regulated in cancer associated blood vessels, fibroblasts and epithelial cells (17). Moreover, epigenetic alteration of EDNRB expression by aberrant methylation has an important role in the pathogenesis of hepatocellular carcinoma (18), and in gastric cancer (19).…”

Section: Endothelin Receptors Type a And Bmentioning

confidence: 99%

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Aspects of the endothelin system in colorectal cancer

et al. 2014

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Section: Variation Of Endothelin Axis Components' Expression In Colorsupporting

confidence: 71%

Section: Endothelin Receptors Type a And Bmentioning

confidence: 99%

Aspects of the endothelin system in colorectal cancer

et al. 2014

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“…These findings indicate that these factors are closely associated with tumor development (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 85%

Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A single-center study

et al. 2014

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Abstract. Pituitary tumors usually originate as benign sporadic adenomas and develop into invasive and aggressive tumors such as prolactinomas, which are common functioning pituitary adenomas. The aim of the present study was to examine the association between the tumor behavior in prolactinomas and the p16(CDKN2A) gene polymorphism occurring at the 3'-untranslated region of exon 3 (C540G). A total of 104 patients with prolactinoma were included and assigned to two groups based on invasive vs. non-invasive tumor behavior. Ki67 indices were recorded according to histopathology results. Genotypic analysis of the p16(CDKN2A) C540G polymorphism was carried out using a modified polymerase chain reaction-restriction fragment length polymorphism assay. The corresponding frequencies for CC, CG and GG genotypes in non-invasive vs. invasive tumors were 61.5, 30.8, 7.7 and 64.1, 28.2, 7.7%, respectively (not significant). The observed CG genotype frequency was higher compared with previous studies. In addition, the patients with giant adenomas or a high Ki67 index had a higher frequency of the CG genotype as compared with the other subgroups, although the differences were not significant (46.2 and 42.9%, respectively). In conclusion, a higher frequency of the C540G CG genotype of the CDKN2A gene was found among patients with prolactinoma in comparison with previous studies. These frequencies were also higher in the subgroups with elevated Ki67 or giant adenomas. Further studies are required to improve the definition of the role of the CG genotype in the development and progression of tumors in prolactinomas.

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“…These data suggest that loss of tumor suppressor gene in 13q may be an early event in the Table 4). Alterations of EDNRB are frequent in a wide range of malignancies, in leiomyosarcoma as well as in other soft-tissue sarcomas (Hsu et al 2006). Array-CGH method has revealed recurrent losses at10q in the region of 10q23.31, 10q 25.2-q25.3, and 10q26.2.…”

Section: Discussionmentioning

confidence: 98%