Aberrant Methylation of Different DNA Repair Genes Demonstrates Distinct Prognostic Value for Esophageal Cancer

Ling, Zhi‐Qiang; Li, Pei; Ge, Minghua; Hu, Fang; Fang, Xian-Hua; Dong, Zi-Min; Mao, Weimin

doi:10.1007/s10620-011-1774-z

Cited by 29 publications

(29 citation statements)

References 39 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current results demonstrated that no correlation was found between MGMT promoter methylation and gender, cigarette smoking, or drinking behavior, which were consistent with the results of an individual study. Baumann et al [36] reported the correlation between MGMT promoter methylation and tumor differentiation among 132 patients, but other 2 studies involving 335 patients showed no correlation between MGMT promoter methylation and tumor differentiation [27,29]. The current results demonstrated that MGMT promoter methylation was not linked to tumor differentiation.…”

Section: Discussioncontrasting

confidence: 46%

“…Based on the selection criteria for the eligible studies, eventually 17 articles were identified in this meta-analysis [21,22,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] these studies included a total of 1,368 patients with esophageal carcinoma and 1,489 nonmalignant controls. Sixteen studies evaluated the association between MGMT promoter methylation and esophageal carcinoma risk in cancer vs. nonmalignant controls [21,22,[28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Eight studies with 928 esophageal carcinoma patients analyzed the correlation between MGMT promoter methylation and the clinical features [21, 27-30, 32, 36, 37].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Significance of O-6-Methylguanine-DNA-Methyltransferase Promoter Methylation in Patients with Esophageal Carcinoma: A Systematic Meta-Analysis

Zhang

Tong²

2017

Dig Dis

View full text Add to dashboard Cite

Background: The correlation between O-6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and esophageal cancer remains controversial. This study was conducted to evaluate the clinical effect of MGMT promoter methylation on esophageal carcinoma patients. Methods: A literature search was conducted in the PubMed, EMBASE, EBSCO, and Cochrane Library databases. The overall OR and corresponding 95% CI were calculated using the random-effects model. Results: Finally, 17 eligible studies were identified in this meta-analysis; these studies included a total of 1,368 patients with esophageal carcinoma and 1,489 with nonmalignant controls. MGMT promoter methylation was significantly higher in esophageal carcinoma tissue samples than in nonmalignant tissue samples (OR 3.64, p < 0.001). Promoter methylation of the MGMT gene was not associated with gender, cigarette smoking, drinking behavior, or tumor differentiation, but MGMT promoter methylation was correlated with age (≥60 vs. <60 years: OR 1.64, p = 0.028), lymph node status (positive status vs. negative status: OR 2.39, p = 0.024), and clinical stage (stages 3-4 vs. 1-2: OR 10.59, p < 0.001). Conclusions: Our findings suggest that MGMT promoter methylation may be correlated with esophageal cancer carcinogenesis and could be associated with age, lymph node status, and clinical stage.

show abstract

Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Clinical Significance of O-6-Methylguanine-DNA-Methyltransferase Promoter Methylation in Patients with Esophageal Carcinoma: A Systematic Meta-Analysis

Zhang

Tong²

2017

Dig Dis

View full text Add to dashboard Cite

show abstract

“…In the present study, no loss of DNA methylation in oral cells was detected. Other studies have found changes in the DNA methylation of MLH1 gene compared with healthy individuals with individuals with cancer, and hypermethylation was detected in colorectal cancer (Kane et al 1997), gastric cancer (Alves et al 2011), esophagic cancer (Ling et al 2011) and lung cancer (Gomes et al 2014). These studies also found association between hypermethylation and gene repression.…”

Section: Resultsmentioning

confidence: 82%

Age-related Changes in DNA Methylation Status of hTERT Gene Promoter of Oral Epithelial Cells

Bezerra¹,

Costa²,

Freitas³

et al. 2014

Braz. arch. biol. technol.

View full text Add to dashboard Cite

The purpose of this study was to investigate the effect of aging on the DNA methylation status of two genes involved in tumorigenesis (telomerase gene hTERT and DNA repair gene-MLH1) and one in metabolism (methylenetetrahydrofolate reductase gene-MTHFR) in oral epithelial cells. DNA methylation analysis was performed by Methylation Sensitive Restriction Enzymes (MSRE) of healthy oral epithelial cells of child (6-10 years, n=21), young (20-25 years, n=19) and elderly (over 60 years, n=25

show abstract

“…MLH1 encodes a protein that has been implicated in the maintenance of genome stability during DNA replication (21)(22)(23). A previous study indicated that MLH1 promoter hypermethylation was able to inactivate gene transcription, inducing defects in the function of the DNA repair system (24). Therefore, MLH1 contributes to the subsequent development of tumors including ESCC (24,25).…”

Section: Introductionmentioning

confidence: 99%

“…A previous study indicated that MLH1 promoter hypermethylation was able to inactivate gene transcription, inducing defects in the function of the DNA repair system (24). Therefore, MLH1 contributes to the subsequent development of tumors including ESCC (24,25). MLH1 promoter methylation is significantly higher in EC tissues, as compared with paired adjacent tissues (15); however, the association between MLH1 promoter methylation and the prognosis of EC has yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of MLH1 promoter methylation in male patients with esophageal squamous cell carcinoma

Chen

et al. 2017

Oncology Letters

View full text Add to dashboard Cite

Abstract. The DNA mismatch repair (MMR) gene MutL homolog 1 (MLH1) is critical for the maintenance of genomic integrity. Methylation of the MLH1 gene promoter was identified as a prognostic marker for numerous types of cancer including glioblastoma, colorectal, ovarian and gastric cancer. The present study aimed to determine whether MLH1 promoter methylation was associated with survival in male patients with esophageal squamous cell carcinoma (ESCC). Formalin-fixed, paraffin-embedded ESCC tissues were collected from 87 male patients. MLH1 promoter methylation was assessed using the methylation-specific polymerase chain reaction approach. Kaplan-Meier survival curves and log-rank tests were used to evaluate the association between MLH1 promoter methylation and overall survival (OS) in patients with ESCC. Cox regression analysis was used to obtain crude and multivariate hazard ratios (HR), and 95% confidence intervals (CI). The present study revealed that MLH1 promoter methylation was observed in 53/87 (60.9%) of male patients with ESCC. Kaplan-Meier survival analysis demonstrated that MLH1 promoter hypermethylation was significantly associated with poorer prognosis in patients with ESCC (P=0.048). Multivariate survival analysis revealed that MLH1 promoter hypermethylation was an independent predictor of poor OS in male patients with ESCC (HR=1.716; 95% CI=1.008-2.921). Therefore, MLH1 promoter hypermethylation may be a predictor of prognosis in male patients with ESCC.

show abstract

Aberrant Methylation of Different DNA Repair Genes Demonstrates Distinct Prognostic Value for Esophageal Cancer

Abstract: Promoter CpG island methylation may be a frequent event in ESCC carcinogenesis. Detection of the methylated sequences of hMLH1, hMSH2, and MGMT appears to be promising as a predictive factor in primary ESCC.

Cited by 29 publications

References 39 publications

Clinical Significance of O-6-Methylguanine-DNA-Methyltransferase Promoter Methylation in Patients with Esophageal Carcinoma: A Systematic Meta-Analysis

Clinical Significance of O-6-Methylguanine-DNA-Methyltransferase Promoter Methylation in Patients with Esophageal Carcinoma: A Systematic Meta-Analysis

Age-related Changes in DNA Methylation Status of hTERT Gene Promoter of Oral Epithelial Cells

Prognostic value of MLH1 promoter methylation in male patients with esophageal squamous cell carcinoma

Contact Info

Product

Resources

About