Aberrant Luteinizing Hormone-Releasing Hormone-Stimulated Adrenocorticotropic Hormone Secretion in a Patient with Pituitary Hyperplasia due to Primary Hypothyroidism.

Ban, Yoshiyuki; Ban, Yoshio; Taniyama, Matsuo; Hara, Hideo; Abe, Takumi; Kubo, Takashi

doi:10.1507/endocrj.47.481

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…The literature search yielded 649 potentially relevant articles, spanning from January 1996 to December 2023. Following the removal of duplicates and the review of titles, abstracts, and full-length articles, we identified 55 articles [ 6 , 9 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ,…”

Section: Resultsmentioning

confidence: 99%

Pituitary Hyperplasia Due to Longstanding Primary Hypothyroidism: A Case Report and Comprehensive Review of the Literature

Roux,

Rosso,

Cuboni

et al. 2024

Biomedicines

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Hypothyroidism is a frequently diagnosed endocrine disorder. Common signs and symptoms include fatigue, cold intolerance, hoarseness, dry skin, constipation, a slow relaxation phase of deep tendon reflexes, and bradycardia. However, some patients may exhibit atypical signs and symptoms, which can result in diagnostic confusion. Pituitary hyperplasia resulting from longstanding primary hypothyroidism was first described by Niepce in 1851. It is usually asymptomatic, but sometimes, in addition to symptoms of overt hypothyroidism, patients may complain of headaches, hypopituitarism, visual field impairment, and hyperprolactinemia. Furthermore, on imaging, pituitary hyperplasia can be mistaken for a pituitary adenoma. Distinguishing between the two is crucial, as their management differs; the former often responds to thyroid hormone replacement therapy, while the latter might need treatment with surgery and/or radiotherapy. Here we describe a patient who developed pituitary hyperplasia in the setting of longstanding uncompensated primary hypothyroidism due to a lack of compliance with levothyroxine replacement therapy. We also review the clinical, laboratory, and radiologic findings of the case reports available in the literature up to now in order to improve the knowledge and the care of the disease.

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