Aberrant Interaction of the Gut Immune System with Environmental Factors in the Development of Food Allergies

Kunisawa, Jun; Kiyono, Hiroshi

doi:10.1007/s11882-010-0097-z

Cited by 15 publications

(9 citation statements)

References 53 publications

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“…The immunological environment in IgE-mediated food allergies is dominated by T H 2, which recruit inflammatory cells through the secretion of IL-4 and IL-13 [33]. T regs , on the contrary, are essential in the induction of oral tolerance to food allergens [34].…”

Section: The Microbiota In Food Allergiesmentioning

confidence: 99%

Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases

Shen

Clemente

2015

Curr Allergy Asthma Rep

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The incidence of immune disorders is growing parallel with practices associated with westernization, such as dietary changes, increased use of antibiotics, or elevated rates of Cesarean section. These practices can significantly impact the gut microbiota, the collection of bacteria residing in the human gastrointestinal tract, and subsequently disrupt the delicate balance existing between commensal flora and host immune responses. Restoring this balance by modifying the microbiota has thus emerged as a promising therapeutic approach. Here, we discuss the interaction between gut commensals and immunity, along with the potential of different interventions on the microbiota as treatment for inflammatory and allergic diseases.

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Section: The Microbiota In Food Allergiesmentioning

confidence: 99%

Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases

Shen

Clemente

2015

Curr Allergy Asthma Rep

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“…Tight junctions among the epithelial cells represent a further barrier controlling the uptake of allergenic material from the gut lumen. For a disruption of this physical barrier (eg, due to physiologic stress or bacterial infections), a higher risk of the development of sensitization has been shown [34].…”

Section: Gut Barrier Dysfunctionmentioning

confidence: 99%

“…In particular, interactions among immunocompetent cells of the host's immune system (eg, T cells, dendritic cells, endothelial cells, and basophils) as well as immunologic modification induced by dietary material [34,36] and bacterial products (eg, CpG and adenosine triphosphate) are important factors for the development and maintenance of immunologic tolerance, and their dysregulation may have an impact in leading to the development of food allergies.…”

Section: Immune Responsementioning

confidence: 99%

Food Allergy and Atopic Dermatitis: How Are They Connected?

Heratizadeh

Wichmann

Werfel

2011

Curr Allergy Asthma Rep

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Food allergy predominantly affects children rather than adults with atopic dermatitis (AD). Early food sensitization has been found to be significantly associated with AD. Three different patterns of clinical reactions to food allergens in AD patients have been identified: 1) immediate-type symptoms, 2) isolated eczematous late-type reactions, and 3) combined reactions. Whereas in children, allergens from cow's milk, hen's egg, soy, wheat, fish, peanut, or tree nuts are primarily responsible for allergic reactions, birch pollen-related food allergens seem to play a major role in adolescent and adults with AD in Central and Northern Europe. Defects in the epidermal barrier function seem to facilitate the development of sensitization to allergens following epicutaneous exposure. The relevance of defects in the gut barrier as well as genetic characteristics associated with an increased risk of food allergy remain to be further investigated. Many studies focus on sufficient strategies of prevention, which actually include breastfeeding or feeding with hydrolyzed formula during the first 4 months of life.

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“…The preferential activation of Th2 cells leads to IgE production and infiltration of mast cells. Mast cells produce inflammatory mediators such as histamine, prostaglandins, and leukotrienes in response to surface binding of IgE with the allergen, and also promote the recruitment of eosinophils and the constriction of smooth muscle [15]. …”

Section: Gut Microbiota and Adverse Food Reactionsmentioning

confidence: 99%

Role of Gut Microbiota in Food Tolerance and Allergies

Gigante¹,

Tortora²,

Ianiro³

et al. 2011

Dig Dis

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Alterations of commensal flora may cause various gastrointestinal and extraintestinal diseases, including food intolerances and food allergies. According to the ‘microflora hypothesis’, alterations in the composition of gut microbiota in industrialized countries have disturbed the mechanisms of mucosal immune tolerance. Over the past few years several studies have looked for a role for probiotics in the treatment of food allergies with promising results.

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Aberrant Interaction of the Gut Immune System with Environmental Factors in the Development of Food Allergies

Cited by 15 publications

References 53 publications

Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases

Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases

Food Allergy and Atopic Dermatitis: How Are They Connected?

Role of Gut Microbiota in Food Tolerance and Allergies

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