Aberrant <i><scp>GSTP</scp>1</i> promoter methylation predicts short‐term prognosis in acute‐on‐chronic hepatitis B liver failure

Gao, Shuai; Sun, Feifei; Fan, Yu–Chen; Shi, Christopher; Zhang, Z.-H.; Wang, L.-Y.; Wang, K.

doi:10.1111/apt.13271

Cited by 29 publications

(24 citation statements)

References 41 publications

(55 reference statements)

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“…In CHB patients who progress to HCC, GST-P1 expression decreases compared to patients in earlier stages of the disease, and its level correlates positively with MDA and xanthine oxidase expression and negatively with GSH levels [326]. Specifically, acute-on-chronic hepatitis B patients are characterized by frequent GSTP1 (hyper)methylation, leading to the absence of expression of this protein [327]. GSTP1 (hyper)methylation is a hallmark of carcinogenesis and the most common molecular alteration in human cancer [328, 329].…”

Section: Hepatitis C Virusmentioning

confidence: 99%

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Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

et al. 2016

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Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review.

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Section: Hepatitis C Virusmentioning

confidence: 99%

“…GSTP1 (hyper)methylation is a hallmark of carcinogenesis and the most common molecular alteration in human cancer [328, 329]. In HBV infection as well, high GSTP1 methylation status predicts a poor prognosis [327]. …”

Section: Hepatitis C Virusmentioning

confidence: 99%

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

et al. 2016

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“…Biochemical measurements were conducted as our previously described. 8 The serum biochemical markers (COBAS integra 800, Roche Diagnostics, Penzberg, Germany) included alanine aminotransferase, aspartate aminotransferase, gammaglutamyl transferase, fasting blood glucose (FBG), cholesterol, triglycerides (TG), high-density lipoprotein, and low-density lipoprotein, blood urea nitrogen, and creatinine. Hematological markers (Sysmex XE-2100; Sysmex Corporation, Chuoku, Kobe, Japan) included hemoglobin (HGB), white blood cells, and platelets.…”

Section: Methodsmentioning

confidence: 99%

“…However, it has several limitations including poor patient compliance, deficient reproducibility, sampling error, and lack of dynamic surveillance and follow up. Liver biopsy leads to pain in 30% of the patients, severe complications in 0.3% of the patients, and death in 0.03% of the patients . Previous studies have demonstrated that ultrasonography allows for reliable and accurate detection of NAFLD, compared with histopathology .…”

Section: Introductionmentioning

confidence: 99%

“…Liver biopsy leads to pain in 30% of the patients, severe complications in 0.3% of the patients, and death in 0.03% of the patients. 8 Previous studies have demonstrated that ultrasonography allows for reliable and accurate detection of NAFLD, compared with histopathology. 9 Meanwhile, ultrasound can provide additional diagnostic information.…”

Section: Introductionmentioning

confidence: 99%

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A model to predict the onset of non‐alcoholic fatty liver disease within 2 years in elderly adults

Lin

Gao

Pan

et al. 2017

J of Gastro and Hepatol

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Epigenetic regulation in lung cancer

Ramazi,

Dadzadi,

Sahafnejad

et al. 2023

MedComm

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Lung cancer is indeed a major cause of cancer‐related deaths worldwide. The development of tumors involves a complex interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms, including DNA methylation (DNAm), histone modifications, and microRNA expression, play a crucial role in this process. Changes in DNAm patterns can lead to the silencing of important genes involved in cellular functions, contributing to the development and progression of lung cancer. MicroRNAs and exosomes have also emerged as reliable biomarkers for lung cancer. They can provide valuable information about early diagnosis and treatment assessment. In particular, abnormal hypermethylation of gene promoters and its effects on tumorigenesis, as well as its roles in the Wnt signaling pathway, have been extensively studied. Epigenetic drugs have shown promise in the treatment of lung cancer. These drugs target the aberrant epigenetic modifications that are involved in the development and progression of the disease. Several factors have been identified as drug targets in non‐small cell lung cancer. Recently, combination therapy has been discussed as a successful strategy for overcoming drug resistance. Overall, understanding the role of epigenetic mechanisms and their targeting through drugs is an important area of research in lung cancer treatment.

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Aberrant GSTP1 promoter methylation predicts short‐term prognosis in acute‐on‐chronic hepatitis B liver failure

Abstract: SUMMARY BackgroundGlutathione-S-transferase P1 (GSTP1) methylation has been demonstrated to be associated with oxidative stress induced liver damage in acute-on-chronic hepatitis B liver failure (ACHBLF).

Cited by 29 publications

References 41 publications

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

A model to predict the onset of non‐alcoholic fatty liver disease within 2 years in elderly adults

Epigenetic regulation in lung cancer

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