Aberrant histone acetylation and methylation levels in woman with endometriosis

Xia, Xiaomeng; Zhao, Ming; Ma, Jin; Fang, Xiaoling

doi:10.1007/s00404-012-2591-0

Cited by 46 publications

(41 citation statements)

References 40 publications

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“…The precise mechanisms were unknown. In some transforming conditions, such as thyroid tumor and endometriosis, different acetylation of histone H3 and H4 occurred separately during transformation [29,30]. We considered that T-cell leukemia and B-cell leukemia might show different acetylation of histones during development of drug resistance.…”

Section: Discussionmentioning

confidence: 99%

Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase

Yamanishi

Narazaki

Asano

2015

Experimental Hematology

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Section: Discussionmentioning

confidence: 99%

Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase

Yamanishi

Narazaki

Asano

2015

Experimental Hematology

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“…54,55 It was recently shown that different types of lesions vary in the expression of HDACs 56,57 and that tissues (lesions and endometrium) from patients have different levels of H3K9 and H4K16 acetylation compared to control tissues. 58,59 Thus, evidence has started to accumulate that endometriotic lesions have a characteristic histone code and that global H3 and H4 acetylation within promoter regions of candidate genes is differentially modulated in lesions.…”

Section: Recommendation (New)mentioning

confidence: 99%

Research Priorities for Endometriosis: Recommendations From a Global Consortium of Investigators in Endometriosis

et al. 2017

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The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/ symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and

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“…6,29,68,69 A recent study that compared global H3 and H4 acetylation status and H3K4 and H3K9 methylation in lesions versus endometrium from healthy women showed what can be perceived as different results from those presented here; however, data sets are difficult to compare due to lack of detail in technical and analytical methods as well as due to differences in the reference group. 40 A study by Munro et al investigated the global histone acetylation levels in normal endometrium during the menstrual cycle. 31,70 They reported that acetylation levels of some but not all histone acetylation marks were increased in the early proliferative phase and/or during the window of implantation, when active transcription of genes would be expected.…”

Section: Waf1/cip1mentioning

confidence: 99%

“…[35][36][37][38][39] However, very few studies have been conducted on endometriosis in this regard. 40 As a first step in dissecting the role of this epigenetic mechanism in endometriosis, we quantified the global acetylation levels of H3 and H4 in ectopic and eutopic endometrial tissues from patients with and without endometriosis. We hypothesized that lesions will have globally deacetylated histones.…”

Section: Waf1/cip1mentioning

confidence: 99%

Endometriosis Is Characterized by a Distinct Pattern of Histone 3 and Histone 4 Lysine Modifications

Monteiro

Colon-Diaz

García³

et al. 2014

Reprod. Sci.

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Background: The histone modification patterns in endometriosis have not been fully characterized. This gap in knowledge results in a poor understanding of the epigenetic mechanisms (and potential therapeutic targets) at play. We aimed to (1) assess global acetylation status of histone 3 (H3) and histone 4 (H4), (2) measure levels of H3 and H4 lysine (K) acetylation and methylation, and (3) to identify histone acetylation patterns in promoter regions of candidate genes in tissues from patients and controls. Methods: Global and K-specific acetylation/methylation levels of histones were measured in 24 lesions, 15 endometrium from patients, and 26 endometrium from controls. Chromatin immunoprecipitation (ChIP)-polymerase chain reaction was used to determine the histone acetylation status of the promoter regions of candidate genes in tissues. Results: The lesions were globally hypoacetylated at H3 (but not H4) compared to eutopic endometrium from controls. Lesions had significantly lower levels of H3K9ac and H4K16ac compared to eutopic endometrium from patients and controls. Tissues from patients were hypermethylated at H3K4, H3K9, and H3K27 compared to endometrium from controls. The ChIP analysis showed hypoacetylation of H3/H4 within promoter regions of candidate genes known to be downregulated in endometriosis (e.g., HOXA10, ESR1, CDH1, and p21 WAF1/Cip1 ) in lesions versus control endometrium. The stereoidogenic factor 1 (SF1) promoter region was enriched for acetylated H3 and H4 in lesions versus control tissues, correlating with its reported high expression in lesions. Conclusions: This study describes the histone code of lesions and endometrium from patients with endometriosis and provides support for a possible role of histone modification in modulation of gene expression in endometriosis.

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Aberrant histone acetylation and methylation levels in woman with endometriosis

Abstract: Aberrant histone modification may play an important role in the pathogenesis of endometriosis.

Cited by 46 publications

References 40 publications

Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase

Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase

Research Priorities for Endometriosis: Recommendations From a Global Consortium of Investigators in Endometriosis

Endometriosis Is Characterized by a Distinct Pattern of Histone 3 and Histone 4 Lysine Modifications

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